Patents by Inventor Henrik Bisg.ang.rd-Frantzen
Henrik Bisg.ang.rd-Frantzen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6143708Abstract: The invention relates to a variant of a parent Termamyl-like .alpha.-amylase, which variant has a-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent a-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca.sup.2+ dependency and specific activity.Type: GrantFiled: October 29, 1998Date of Patent: November 7, 2000Assignee: Novo Nordisk A/SInventors: Allan Svendsen, Torben Vedel Borchert, Henrik Bisg.ang.rd-Frantzen
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Patent number: 6093562Abstract: The present invention relates to variants of a parent .alpha.-amylase, which parent .alpha.-amylase (i) has an amino acid sequence selected from the amino acid sequences shown in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, and SEQ ID No. 7, respectively; or (ii) displays at least 80% homology with one or more of these amino acid sequences; and/or displays immunological cross-reactivity with an antibody raised against an .alpha.-amylase having one of these amino acid sequences; and/or is encoded by a DNA sequence which hybridizes with the same probe as a DNA sequence encoding an .alpha.-amylase having one of these amino acid sequences; in which variant:(a) at least one amino acid residue of the parent .alpha.-amylase has been deleted; and/or(b) at least one amino acid residue of the parent .alpha.-amylase has been replaced by a different amino acid residue; and/or(c) at least one amino acid residue has been inserted relative to the parent .alpha.-amylase; the variant having .alpha.Type: GrantFiled: February 13, 1996Date of Patent: July 25, 2000Assignee: Novo Nordisk A/SInventors: Henrik Bisg.ang.rd-Frantzen, Allan Svendsen, Torben Vedel Borchert
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Patent number: 6087149Abstract: The present invention relates to a starch conversion process of the type which includes a debranching step wherein an isoamylase being active at the process conditions prevailing is used for debranching the starch and to the use of thermostable isoamylases for starch conversion. The invention further relates to an isolated isoamylase obtained from a strain of the genus Rhodothermus and to cloned DNA sequences encoding isoamylases derived from a strain of Rhodothermus or Sulfolobus, to expression vectors comprising said DNA sequence, host cells comprising such expression vectors, and finally to methods for producing said isoamylases.Type: GrantFiled: August 4, 1998Date of Patent: July 11, 2000Assignee: Novo Nordisk A/SInventors: Noriko Tsutsumi, Henrik Bisg.ang.rd-Frantzen, Allan Svendsen
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Patent number: 6022724Abstract: The present invention relates to a method of constructing a variant of a parent Termamyl-like .alpha.-amylase, which variant has .alpha.-amylase activity and at least one altered property as compared to the parent .alpha.-amylase, comprisesi) analyzing the structure of the parent Termamyl-like .alpha.-amylase to identify at least one amino acid residue or at least one structural part of the Termamyl-like .alpha.-amylase structure, which amino acid residue or structural part is believed to be of relevance for altering the property of the parent Termamyl-like .alpha.-amylase (as evaluated on the basis of structural or functional considerations),ii) constructing a Termamyl-like .alpha.-amylase variant, which as compared to the parent Termamyl-like .alpha.-amylase, has been modified in the amino acid residue or structural part identified in i) so as to alter the property, and, optionally,iii) testing the resulting Termamyl-like .alpha.-amylase variant with respect to the property in question.Type: GrantFiled: July 18, 1996Date of Patent: February 8, 2000Assignee: Novo Nordisk A/SInventors: Allan Svendsen, Henrik Bisg.ang.rd-Frantzen, Torben Borchert
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Patent number: 6017749Abstract: This invention relates to Alkalophilic Bacillus sp. AC13 microorganisms and cultures, and mutants and variants thereof, and to enzymes obtainable from the microorganism.Type: GrantFiled: February 10, 1998Date of Patent: January 25, 2000Assignee: Novo Nordisk A/SInventors: Helle Outtrup, Claus Dambmann, Arne Agerlin Olsen, Henrik Bisg.ang.rd-Frantzen, Martin Schulein
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Patent number: 5989169Abstract: The present invention relates to a method of constructing a variant of a parent Termamyl-like .alpha.-amylase, which variant has .alpha.-amylase activity and at least one altered property as compared to the parent .alpha.-amylase, comprising i) analyzing the structure of the parent Termamyl-like .alpha.-amylase to identify at least one amino acid residue or at least one structural part of the Termamyl-like .alpha.-amylase structure, which amino acid residue or structural part is believed to be of relevance for altering the property of the parent Termamyl-like .alpha.-amylase (as evaluated on the basis of structural or functional considerations), ii) constructing a Termamyl-like .alpha.-amylase variant, which as compared to the parent Termamyl-like .alpha.-amylase, has been modified in the amino acid residue or structural part identified in i) so as to alter the property, and iii) testing the resulting Termamyl-like .alpha.-amylase variant for the property in question.Type: GrantFiled: February 13, 1996Date of Patent: November 23, 1999Assignee: Novo Nordisk A/SInventors: Allan Svendsen, Henrik Bisg.ang.rd-Frantzen, Torben Vedel Borchert
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Patent number: 5981253Abstract: The present invention relates to novel microorganisms, novel enzymes obtainable herefrom, and to a method of producing the novel enzymes. More specifically, the invention relates to novel enzymes obtainable from strains of the novel alkalophilic species Bacillus sp. AC13. Moreover, the invention relates to a method for producing the enzymes of the invention, and to the use of the enzymes in detergents or in the paper pulp industry.Type: GrantFiled: June 6, 1995Date of Patent: November 9, 1999Assignee: Novo Nordisk A/SInventors: Helle Outtrup, Claus Dambmann, Arne Agerlin Olsen, Henrik Bisg.ang.rd-Frantzen, Martin Schulein
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Patent number: 5945327Abstract: An isolated nucleic acid constructs encoding cellulytic enzymes derived from a strain of Bacillus agaradherens, recombinant vectors and host cells comprising such constructs, and methods for obtaining cellulytic enzymes.Type: GrantFiled: June 6, 1997Date of Patent: August 31, 1999Assignee: Novo Nordisk A/SInventors: Helle Outtrup, Claus Dambmann, Arne Agerlin Olsen, Henrik Bisg.ang.rd-Frantzen, Martin Schulein, Per Linaa Jorgensen, Mads E. Bjoernvad
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Patent number: 5922586Abstract: An isolated nucleic acid constructs encoding cellulytic enzymes derived from a strain of Bacillus agaradherens, recombinant vectors and host cells comprising such constructs, and methods for obtaining cellulytic enzymes.Type: GrantFiled: September 13, 1996Date of Patent: July 13, 1999Assignee: Novo Nordisk A/SInventors: Helle Outtrup, Claus Dambmann, Arne Agerlin Olsen, Henrik Bisg.ang.rd-Frantzen, Martin Schulein, Per Linaa Jorgensen, Mads E. Bjoernvad
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Patent number: 5856164Abstract: An .alpha.-amylase characterized by having a specific activity at least 25% higher than the specific activity of Termamyl.RTM. at a temperature in the range of 25.degree. C. to 55.degree. C. and at a pH value in the range of pH 8 to pH 10.Type: GrantFiled: May 22, 1997Date of Patent: January 5, 1999Assignee: Novo Nordisk A/SInventors: Helle Outtrup, Henrik Bisg.ang.rd-Frantzen, Peter Rahbek stergaard, Michael Dolberg Rasmussen, Pia Van Der Zee
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Patent number: 5830837Abstract: A variant of a parent .alpha.-amylase enzyme having an improved washing and/or dishwashing performance as compared to the parent enzyme, wherein one or more amino acid residues of the parent enzyme have been replaced by a different amino acid residue and/or wherein one or more amino acid residues of the parent .alpha.-amylase have been deleted and/or wherein one or more amino acid residues have been added to the parent .alpha.-amylase enzyme, provided that the variant is different from one in which the methionine residue in position 197 of a parent B. licheniformis .alpha.-amylase has been replaced by alanine or threonine, as the only modification being made. The variant may be used for washing and dishwashing.Type: GrantFiled: November 22, 1994Date of Patent: November 3, 1998Assignee: Novo Nordisk A/SInventors: Henrik Bisg.ang.rd-Frantzen, Torben Vedel Borchert, Allan Svendsen, Marianne Thellersen, Pia Van der Zee
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Patent number: 5824531Abstract: An .alpha.-amylase characterized by having a specific activity at least 25% higher than the specific activity of Termamyl.RTM. at a temperature in the range of 25.degree. C. to 55.degree. C. and a pH value in the range of pH 8 to pH 10.Type: GrantFiled: June 1, 1995Date of Patent: October 20, 1998Assignee: Novid NordiskInventors: Helle Outtrup, Henrik Bisg.ang.rd-Frantzen, Peter Rahbek stergaard, Michael Dolberg Rasmussen, Pia Van der Zee
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Patent number: 5801043Abstract: A variant of a parent .alpha.-amylase enzyme having an improved washing and/or dishwashing performance as compared to the parent enzyme, wherein one or more amino acid residues of the parent enzyme have been replaced by a different amino acid residue and/or wherein one or more amino acid residues of the parent .alpha.-amylase have been deleted and/or wherein one or more amino acid residues have been added to the parent .alpha.-amylase enzyme, provided that the variant is different from one in which the methionine residue in position 197 of a parent B. licheniformis .alpha.-amylase has been replaced by alanine or threonine, as the only modification being made. The variant may be used for washing and dishwashing.Type: GrantFiled: June 2, 1995Date of Patent: September 1, 1998Assignee: Novo Nordisk A/SInventors: Henrik Bisg.ang.rd-Frantzen, Torben Vedel Borchert, Allan Svendsen, Marianne Thellersen, Pia Van der Zee
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Patent number: 5770424Abstract: The present invention is directed to isolated nucleic acid constructs comprising a nucleic acid sequence encoding xylanolytic enzymes derived from a strain of Bacillus agaradherens, recombinant vectors and host cells comprising such constructs, and methods for obtaining xylanolytic enzymes.Type: GrantFiled: August 16, 1996Date of Patent: June 23, 1998Assignee: NovoNordisk A/SInventors: Helle Outtrup, Claus Dambmann, Arne Agerlin Olsen, Henrik Bisg.ang.rd-Frantzen, Martin Schulein, Per Linaa Jorgensen
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Patent number: 5741693Abstract: The present invention relates to proteases obtained from a strain of Bacillus sp. AC13, and having (a) an apparent molecular weight of approximately 30 kD as determined by SDS-PAGE; (b) an isoelectric point of approximately 9.3 as determined by isoelectric focusing on LKB Ampholine PAG plates; (c) a pH optimum above 10 determined at 25.degree. C. with casein as substrate; (d) a temperature optimum in the range of 45.degree.-55.degree. C. determined at pH 9.5 with casein as substrate; and (e) immunochemical properties identical or partially identical to those of a protease derived from Bacillus sp. AC13, NCIMB No. 40482.Type: GrantFiled: November 30, 1994Date of Patent: April 21, 1998Assignee: Novo Nordisk A/SInventors: Helle Outtrup, Claus Dambmann, Arne Agerlin Olsen, Henrik Bisg.ang.rd-Frantzen, Martin Schulein
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Patent number: 5696068Abstract: The present invention relates to novel microorganisms, novel enzymes obtainable herefrom, and to a method of producing the novel enzymes. More specifically, the invention relates to novel enzymes obtainable from strains of the novel alkalophilic species Bacillus sp. AC13. Moreover, the invention relates to a method for producing the enzymes of the invention, and to the use of the enzymes in detergents or in the paper pulp industry.Type: GrantFiled: June 6, 1995Date of Patent: December 9, 1997Assignee: Novo Nordisk A/SInventors: Helle Outtrup, Claus Dambmann, Arne Agerlin Olsen, Henrik Bisg.ang.rd-Frantzen, Martin Schulein