Patents by Inventor Henrik Bisgard-Frantzen
Henrik Bisgard-Frantzen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100144575Abstract: The present invention relates to a method of constructing a variant of a parent Termamyl-like ?-amylase, which variant has ?-amylase activity and at least one altered property as compared to the parent ?-amylase, comprises i) analysing the structure of the parent Termamyl-like ?-amylase to identify at least one amino acid residue or at least one structural part of the Termamyl-like ?-amylase structure, which amino acid residue or structural part is believed to be of relevance for altering the property of the parent Termamyl-like ?-amylase (as evaluated on the basis of structural or functional considerations), ii) constructing a Termamyl-like ?-amylase variant, which as compared to the parent Termamyl-like ?-amylase, has been modified in the amino acid residue or structural part identified in i) so as to alter the property, and, optionally, iii) testing the resulting Termamyl-like ?-amylase variant with respect to the property in question.Type: ApplicationFiled: April 10, 2008Publication date: June 10, 2010Applicant: Novozymes A/SInventors: Allan Svendsen, Henrik Bisgard-Frantzen, Torben Vedel Borchert
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Publication number: 20100099597Abstract: The present invention relates to variants of a parent ?-amylase, which parent ?-amylase (i) has an amino acid sequence selected from the amino acid sequences shown in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, and SEQ ID No.Type: ApplicationFiled: July 28, 2008Publication date: April 22, 2010Applicant: NOVOZYMES A/SInventors: HENRIK BISGARD-FRANTZEN, ALLAN SVENDSEN, TORBEN VEDEL BORCHERT
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Publication number: 20100099598Abstract: The present invention relates to variants of a parent ?-amylase, which parent ?-amylase (i) has an amino acid sequence selected from the amino acid sequences shown in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, and SEQ ID No.Type: ApplicationFiled: July 28, 2008Publication date: April 22, 2010Applicant: NOVOZYMES A/SInventors: HENRIK BISGARD-FRANTZEN, ALLAN SVENDSEN, TORBEN VEDEL BORCHERT
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Publication number: 20090317864Abstract: The invention relates to a novel Termamyl-like alpha-amylase, and Termamyl-like alpha-amylases comprising mutations in two, three, four, five or six regions/positions. The variants have increased thermostability at acidic pH and/or at low Ca2+ concentrations (relative to the parent).Type: ApplicationFiled: June 29, 2009Publication date: December 24, 2009Applicant: Novozymes A/SInventors: Allan Svendsen, Torben Vedel Borchert, Henrik Bisgard-Frantzen, Helle Outtrup, Bjarne Ronfeldt Nielsen, Vibeke Skovgaard Nielsen, Lisbeth Hedegaard
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Patent number: 7625737Abstract: The present invention relates to alpha-amylase variants having mutations corresponding to one or more of the following mutations A181E,D,Q,N,V; I201W,F,L; Q264R,D,K,E; Y290R,E,K; and S334A,V,T,L,I,D (using SEQ ID No. 2 for numbering).Type: GrantFiled: November 3, 2004Date of Patent: December 1, 2009Assignee: Novozymes A/SInventors: Allan Svendsen, Torben Vedel Borchert, Henrik Bisgard-Frantzen
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Publication number: 20090280527Abstract: The present invention relates to variants of a parent ?-amylase, which parent ?-amylase (i) has an amino acid sequence selected from the amino acid sequences shown in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, and SEQ ID No.Type: ApplicationFiled: September 21, 2005Publication date: November 12, 2009Applicant: Novozymes A/SInventors: Henrik Bisgard-Frantzen, Allan Svendsen, Torben Borchert
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Patent number: 7566561Abstract: The invention relates to a novel Termamyl-like alpha-amylase, and Termamyl-like alpha-amylases comprising mutations in two, three, four, five or six regions/positions. The variants have increased thermostability at acidic pH and/or at low Ca2+ concentrations (relative to the parent).Type: GrantFiled: December 23, 2002Date of Patent: July 28, 2009Assignee: Novozymes A/SInventors: Allan Svendsen, Torben Vedel Borchert, Henrik Bisgard-Frantzen, Helle Outtrup, Bjarne Ronfeldt Nielsen, Vibeke Skovgaard Nielsen, Lisbeth Hedegaard
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Publication number: 20090155882Abstract: The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant exhibits altered properties, in particular reduced capability of cleaving a substrate close to the branching point, and improved substrate specificity and/or improved specific activity relative to the parent alpha-amylase.Type: ApplicationFiled: November 2, 2007Publication date: June 18, 2009Applicant: Novozymes A/SInventors: Carsten Andersen, Christel Thea Jorgensen, Henrik Bisgard-Frantzen, Allan Svendsen, Soren Kjaerulff
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Publication number: 20090142818Abstract: The present invention relates to a process of producing a fermentation product, especially ethanol, from starch-containing material using an alpha-amylase and a carbohydrate-source generating enzyme. The invention also relates to a composition comprising an alpha-amylase and a carbohydrate-source generating enzyme as well as the use such compositions for producing fermentation products.Type: ApplicationFiled: May 11, 2007Publication date: June 4, 2009Applicant: Novozymes A/SInventors: Henrik Bisgard-Frantzen, Kevin S. Wenger, Michael Trent Elder, Randy Deinhammer, Joyce Aldridge Craig
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Publication number: 20080279980Abstract: The invention relates to a variant of a parent Fungamyl-like fungal alpha-amylase, which exhibits improved thermal stability at acidic pH suitable for, e.g., starch processes.Type: ApplicationFiled: February 18, 2008Publication date: November 13, 2008Applicant: Novozymes A/SInventors: Henrik Bisgard-Frantzen, Allan Svendsen, Sven Pedersen
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Publication number: 20080227174Abstract: The invention relates to a genetically engineered variant of a parent starch debranching enzyme, i.e. a pullulanase or an isamylase, the enzyme variant having an improved thermostability at a pH in the range of 4-6 compared to the parent enzyme and/or an increased activity towards amylopectin and/or glycogen compared to the parent enzyme, to methods for producing such starch debranching enzyme variants with improved thermostability and/or altered substrate specificity, and to a method for converting starch to one or more sugars using at least one such enzyme variant.Type: ApplicationFiled: May 5, 2008Publication date: September 18, 2008Applicant: Novozymes A/SInventors: Henrik Bisgard-Frantzen, Allan Svendsen
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Publication number: 20080227166Abstract: The present invention provides an improved process for producing a fermentation product in a fermentation medium, including ethanol, which process include a fermentation step, comprising subjecting the fermentation medium to at least one surfactant and at least one carbohydrate-source generating enzyme.Type: ApplicationFiled: January 14, 2005Publication date: September 18, 2008Applicants: Novozymes A/S, Novozymes North America, Inc.Inventors: Eric Allain, Kevin S. Wenger, Henrik Bisgard-Frantzen, Lori Henderson, Carmen Costable
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Patent number: 7378264Abstract: The present invention relates to a method of constructing a variant of a parent Termamyl-like ?-amylase, which variant has ?-amylase activity and at least one altered property as compared to the parent ?-amylase, comprises i) analysing the structure of the parent Termamyl-like ?-amylase to identify at least one amino acid residue or at least one structural part of the Termamyl-like ?-amylase structure, which amino acid residue or structural part is believed to be of relevance for altering the property of the parent Termamyl-like ?-amylase (as evaluated on the basis of structural or functional considerations), ii) constructing a Termamyl-like ?-amylase variant, which as compared to the parent Termamyl-like ?-amylase, has been modified in the amino acid residue or structural part identified in i) so as to alter the property, and, optionally, iii) testing the resulting Termamyl-like ?-amylase variant with respect to the property in question.Type: GrantFiled: February 22, 2005Date of Patent: May 27, 2008Assignee: Novozymes A/SInventors: Allan Svendsen, Henrik Bisgard-Frantzen, Torben Vedel Borchert
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Patent number: 7374922Abstract: The invention relates to a genetically engineered variant of a parent starch debranching enzyme, i.e. a pullulanase or an isamylase, the enzyme variant having an improved thermostability at a pH in the range of 4-6 compared to the parent enzyme and/or an increased activity towards amylopectin and/or glycogen compared to the parent enzyme, to methods for producing such starch debranching enzyme variants with improved thermostability and/or altered substrate specificity, and to a method for converting starch to one or more sugars using at least one such enzyme variant.Type: GrantFiled: February 26, 2003Date of Patent: May 20, 2008Assignee: Novozymes A/SInventors: Henrik Bisgard-Frantzen, Allan Svendsen
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Publication number: 20080083406Abstract: The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant has a-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent a-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca2+ dependency and specific activity.Type: ApplicationFiled: September 27, 2007Publication date: April 10, 2008Applicant: Novozymes A/SInventors: Allan Svendsen, Torben Borchert, Henrik Bisgard-Frantzen
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Patent number: 7341858Abstract: The invention relates to a variant of a parent Fungamyl-like fungal alpha-amylase, which exhibits improved thermal stability at acidic pH suitable for, e.g., starch processes.Type: GrantFiled: December 4, 2006Date of Patent: March 11, 2008Inventors: Henrik Bisgård-Frantzen, Allan Svendsen, Sven Pedersen
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Publication number: 20080032373Abstract: The invention relates to a process of producing a fermentation product, such as ethanol, from starch-containing material, including i) subjecting starch-containing material to an alpha-amylase, ii) subjecting the material obtained in step i) to an alpha-glucosidase and/or a maltose-generating enzyme, and iii) fermenting the material in the presence of a fermenting organism, such as yeast. Alternatively the invention relates to a process of producing a fermentation product from starch-containing material, preferably granular starch, which process comprises: a) subjecting starch-containing material to an alpha-glucosidase and optionally a glucose-generating and/or maltose-generating enzyme, and b) fermenting the material in the presence of a fermenting organism.Type: ApplicationFiled: May 11, 2005Publication date: February 7, 2008Applicants: Novozymes North America, Inc., Novozymes A/S.Inventors: Swapnil Bhargava, Henrik Frisner, Henrik Bisgard-Frantzen, Jeppe Tams
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Patent number: 7306936Abstract: The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant exhibits altered properties, in particular reduced capability of cleaving a substrate close to the branching point, and improved substrate specificity and/or improved specific activity relative to the parent alpha-amylase.Type: GrantFiled: May 15, 2002Date of Patent: December 11, 2007Assignee: Novozymes A/SInventors: Carsten Andersen, Christel Thea Jorgensen, Henrik Bisgard-Frantzen, Allan Svendsen, Soren Kjaerulff
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Publication number: 20070141689Abstract: The present invention relates to method of liquefying starch-containing material, wherein the method comprises the steps of (a) treating the starch-containing material with a bacterial alpha-amylase at a temperature around 70-90° C. for 15-90 minutes, and (b) treating the material obtained in step (a) with an alpha-amylase at a temperature between 60-80° C. for 30-90 minutes. The invention also relates to a process of producing a fermentation product, preferably ethanol, comprising a liquefaction step carried out according to the liquefaction method of the invention.Type: ApplicationFiled: March 18, 2005Publication date: June 21, 2007Applicants: Novozymes A/S, Novozymes North American, Inc.Inventors: Swapnil Bhargava, Henrik Bisgard-Frantzen, Henrik Frisner, Anders Vikso-Nielsen, Malcolm Johal
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Publication number: 20070128313Abstract: The invention relates to a variant of a parent Fungamyl-like fungal alpha-amylase, which exhibits improved thermal stability at acidic pH suitable for, e.g., starch processes.Type: ApplicationFiled: December 4, 2006Publication date: June 7, 2007Applicant: Novozymes A/SInventors: Henrik Bisgard-Frantzen, Allan Svendsen, Sven Pedersen