Abstract: A device for fixation of inner and outer bone fragments comprises at least three fixation means (5), at least one tilting preventing means (6) and a securing plate (7). The fixation means (5) are configured to allow, during secondary compression of the inner and outer bone fragments (2, 3), a sliding movement of the fixation means and said outer bone fragment relative to one another and thereby an interruption of an engagement of the securing plate (7) with the outer bone fragment (3) without affecting the angular position of the fixation means relative to the securing plate and relative to one another. The tilting preventing means (6) is configured to allow, during said secondary compression, a sliding movement of the at least one tilting preventing means and said outer bone fragment (3) relative to one another and thereby an interruption of the engagement of the securing plate (7) with the outer bone fragment.

Abstract: A targeting device (100) for use in fixation of bone fragments at a bone fracture. The targeting device comprises an elongated body portion (110) comprising a first body end (111), an opposed second body end (112), and body through holes (113a, 113b, 113c) extending from the first body end to the second body end for guiding a respective fixation means (303; 303a, 303b, 303c) through the body portion. In its second body end the body portion is configured with a snap-fitting means (114) configured to removably attach a fixation plate (150) to the body portion such that fixation through holes (151) of the plate are located in line with a respective body through hole and, when in use, to provide a surface of the plate to abut a surface of an outer bone fragment for subsequent fixation of the plate to the fragment. The targeting device comprises further a bracket (120).

Abstract: The present invention relates to an osseous pin (1) for bone fracture fixation. The pin comprises a threaded front section (2) and an unthreaded rear section (3). The threaded front section is configured with two or more kerfs (4) to facilitate breaking of the pin at any one of said kerfs. The present invention also relates to a guide sleeve for use in insertion of the osseous pin (1) into bone fragments at a bone fracture and breaking of said pin at the kerf (4) closest to the entrance site of the pin into the bone fragments. The present invention also relates to an extraction member for use in extraction of the osseous pin (1) from bone fragments at a healed bone fracture and a kit, comprising said components.

Abstract: A prosthesis for reconstruction of a distal radioulnar joint, after resection of a part of the ulna, includes a first prosthesis member, fixation members and a second prosthesis member. The first prosthesis member is configured for fixation to the distal end portion of the ulna. The fixation members are configured to extend into the radius via said distal end portion of the ulna for locking said distal end portion of the ulna to the radius. The second prosthesis member is configured for fixation to the ulna close to said distal end portion of the ulna. The second prosthesis member is also configured to extend into said space for being joined with the first prosthesis member in a manner which allows said first and second prosthesis members to at least pivot and rotate relative to each other.

Abstract: A device for fixation of bone fragments (4, 8) comprises a locking plate (1) for fixation on the outside of an outer bone fragment (4). The locking plate has a distal portion (1 a) with at least one first hole (6), extending through the locking plate, for a distal fixing means (2) and a proximal portion (1 b) with a second hole (7), extending through the locking plate, for a proximal fixing means (3). The locking plate (1) is configured also with a third hole (9) which is located between said at least one first hole (6) in the distal portion (1 a) of the locking plate and said second hole (7) in the proximal portion (1 b) of the locking plate and this third hole extends as the other holes through the locking plate.

Abstract: A device for fixation of inner and outer bone fragments comprises at least three fixation means (5), at least one tilting preventing means (6) and a securing plate (7). The fixation means (5) are configured to allow, during secondary compression of the inner and outer bone fragments (2, 3), a sliding movement of the fixation means and said outer bone fragment relative to one another and thereby an interruption of an engagement of the securing plate (7) with the outer bone fragment (3) without affecting the angular position of the fixation means relative to the securing plate and relative to one another. The tilting preventing means (6) is configured to allow, during said secondary compression, a sliding movement of the at least one tilting preventing means and said outer bone fragment (3) relative to one another and thereby an interruption of the engagement of the securing plate (7) with the outer bone fragment.

Abstract: A targeting device (100) for use in fixation of bone fragments at a bone fracture. The targeting device comprises an elongated body portion (110) comprising a first body end (111), an opposed second body end (112), and body through holes (113a, 113b, 113c) extending from the first body end to the second body end for guiding a respective fixation means (303; 303a, 303b, 303c) through the body portion. In its second body end the body portion is configured with a snap-fitting means (114) configured to removably attach a fixation plate (150) to the body portion such that fixation through holes (151) of the plate are located in line with a respective body through hole and, when in use, to provide a surface of the plate to abut a surface of an outer bone fragment for subsequent fixation of the plate to the fragment. The targeting device comprises further a bracket (120).

Abstract: The present invention relates to a method for fixing an intramedullary cavity nail for the treatment of unstable trochanteric fractures and to a targeting device for use in performing the steps of said method. According to the method, a recess (16) for a femur neck screw (8) for fixing the cavity nail (2) is provided in at least the lateral cortex of the femoral shaft (FS) in close distal proximity to a hole (9) for the femur neck screw such that bone fragment(s) located distally of the fracture and bone fragment(s) located proximally of the fracture relatively seen can be displaced towards each other. A targeting head (5) of the targeting device (1) is configured with a targeting bore (14) which is alignable with a point on the femoral shaft (FS) in close distal proximity to the hole (9) for the femur neck screw (8) for use in providing at said point, said recess (16) for the femur neck screw.

Abstract: An instrument (1) for use in measuring blood flow in the femoral head after a femoral neck fracture comprises a sleeve (2) and a rod (3) which is displaceably mounted in the sleeve. The sleeve (2) is configured for insertion into a bore (4) in the femoral neck (5) and femoral head (6) and provided with at least one aperture (8) at a front portion (2a) thereof. The aperture (8) in the front portion (2a) of the sleeve (2) is intended for location in the femoral head (6) distally of the fracture (7) after the sleeve has been inserted into said bore (4). The rod (3) is configured for closing the aperture (8) in the sleeve (2) during insertion of the sleeve into the bore (4) in the femoral neck (5) and femoral head (6) and for exposing said aperture after said insertion. Thereby, blood leaking into the bore (4) at the front portion (2a) of the sleeve (2) can be collected by the sleeve through the aperture (8) therein for subsequent measuring of the volume of the collected blood.

Abstract: A prosthesis (1) for reconstruction of a distal radioulnar joint after resection of a part of the ulna close to a distal end portion (U1) thereof, comprises a first prosthesis member (2), fixation means (3) and a second prosthesis member (4). The first prosthesis member (2) is configured for fixation to the distal end portion (U1) of the ulna. The fixation means (3) are configured to extend into the radius via said distal end portion of the ulna for locking said distal end portion of the ulna to the radius. The second prosthesis member (4) is configured for fixation to the ulna (U2) proximally of a space (US) which is defined between the distal end portion (U1) of the ulna and the ulna proximally of said space by the resection of said part of the ulna close to said distal end portion of the ulna.

Abstract: The present invention relates to an osseous pin (1) for bone fracture fixation. The pin comprises a threaded front section (2) and an unthreaded rear section (3). The threaded front section is configured with two or more kerfs (4) to facilitate breaking of the pin at any one of said kerfs. The present invention also relates to a guide sleeve for use in insertion of the osseous pin (1) into bone fragments at a bone fracture and breaking of said pin at the kerf (4) closest to the entrance site of the pin into the bone fragments. The present invention also relates to an extraction member for use in extraction of the osseous pin (1) from bone fragments at a healed bone fracture and a kit, comprising said components.

Abstract: A fixing means (1) for fixation of bone fragments at bone fractures comprises a sleeve (2) and at least one pin (9) which is provided in said sleeve and a front end portion (10) of which can be driven out and retracted through a side opening (8) in the sleeve such that said end portion can be brought to engage bone material in one of the bone fragments and retracted out of the bone material. For facilitating said driving and retraction, the pin (9) comprises a fixing member (9a) with said front end portion (10) and a driving and retraction member (9b) which is rotatably connected to the fixing member.

Abstract: A device for fixation of bone fragments (4, 8) comprises a locking plate (1) for fixation on the outside of an outer bone fragment (4). The locking plate has a distal portion (1 a) with at least one first hole (6), extending through the locking plate, for a distal fixing means (2) and a proximal portion (1 b) with a second hole (7), extending through the locking plate, for a proximal fixing means (3). The locking plate (1) is configured also with a third hole (9) which is located between said at least one first hole (6) in the distal portion (1 a) of the locking plate and said second hole (7) in the proximal portion (1 b) of the locking plate and this third hole extends as the other holes through the locking plate.

Abstract: Provided are certain glycosyl hydrolase family 3 (GH3) beta-xylosidases engineered to acquire beta-glucosidase activities. Provided also are compositions comprising such multi-functional GH3 enzymes and methods of use or industrial applications thereof.

Abstract: Provided are certain glycosyl hydrolase family 3 (GH3) beta-glucosidase enzymes engineered to acquire beta-xylosidase activities. Provided also are compositions comprising multi-functional GH3 enzymes and methods of use or industrial applications thereof.

Abstract: The present invention relates to a device for fixation of bone fragments at bone fractures. The device comprises at least two fixation means (1) and a securing plate (17). The securing plate (17) has threaded holes (19). The fixation means consist of bone nails (1) which each comprises a sleeve (5) with a displaceable pin (7) inside the sleeve. A forward portion (9) of the (7) pin defines a first fixing portion for fixing the bone nail (1) in an inner bone fragment (3). A threaded rear end portion (18) of the sleeve (5) defines a second fixing portion for locking the bone nail (1) to the securing plate (17). The sleeve (5) has a middle portion (32) along which the outer bone fragment (2) can slide inwards towards the inner bone fragment (3).

Abstract: The present invention relates to a method for fixing an intramedullary cavity nail for the treatment of unstable trochanteric fractures and to a targeting device for use in performing the steps of said method. According to the method, a recess (16) for a femur neck screw (8) for fixing the cavity nail (2) is provided in at least the lateral cortex of the femoral shaft (FS) in close distal proximity to a hole (9) for the femur neck screw such that bone fragment(s) located distally of the fracture and bone fragment(s) located proximally of the fracture relatively seen can be displaced towards each other. A targeting head (5) of the targeting device (1) is configured with a targeting bore (14) which is alignable with a point on the femoral shaft (FS) in close distal proximity to the hole (9) for the femur neck screw (8) for use in providing at said point, said recess (16) for the femur neck screw.

Abstract: The present invention relates to a device for fixation of bone fragments at bone fractures. The device comprises at least two fixation means (5, 6) and a securing plate (4). With the object of preventing or counteracting re-dislocation, the respective fixation means (5, 6) each have a first fixing portion (19) for fixing the fixation means in an inner bone fragment (3), a second fixing portion (21) for locking the fixation means to the securing plate (4) which is disposed on the outside of an outer bone fragment (2) and allows movement of the outer bone fragment relative to it, so that the fixation means are prevented from changing their angular position relative to the securing plate and relative to one another, and a middle portion (22) which is situated between the fixing portions and runs through the outer bone fragment, along which middle portion the outer bone fragment can slide inwards towards the inner bone fragment in which the fixation means is fixed.