Publication number: 20090055942
Abstract: The present invention relates to novel human coagulation Factor Vila variants having substitutions of one or more amino acids at a position selected from the group consisting of position 172, 173, 175, 176, 177, 196, 197, 198, 199, 200, 203, 235, 237, 238, 239, 240, 286, 287, 288, 289, 290, 291, 292, 293, 294, 295, 297, 299, 319, 320, 321, 327, 341, 363, 364, 365, 366, 367, 370, 373 corresponding to amino acid positions of SEQ ID NO:1 and wherein said Factor VII polypeptide exhibits increased resistance to inactivation by an endogenous inhibitor of said FVII polypeptide relative to wild-type human FVIIa.
Type:
Application
Filed:
September 14, 2006
Publication date:
February 26, 2009
Applicant:
Novo Nordisk HealthCare A/G
Inventors:
Henrik Ostergaard, Ole Hvilsted Olsen, Katrine Skaarup Larsen, Henning Stennicke