Abstract: A gauge spacing apparatus for positioning pot sleepers with respect to existing sleepers of a railway track has a pair of turnout rails, which are separated from one another by a desired gauge distance. The gauge spacing apparatus includes a first guide member aligned with and secured with respect to a portion of the existing rail; and a second guide member angled with respect to the first guide member at a turnout angle. The second guide member is aligned with a portion of a turnout rail to allow the turnout rail to be provided with supporting pot sleepers, such that the desired gauge between the turnout rails is maintained. Also provided are a rectangular gauge spacing apparatus, a shear plate arrangement for providing supported engagement between first and second sections of rail, and a support framework for supporting a planar supporting member spanning over an existing rail.

Abstract: A gauge spacing apparatus for positioning pot sleepers with respect to existing sleepers of a railway track has a pair of turnout rails, which are separated from one another by a desired gauge distance. The gauge spacing apparatus includes a first guide member aligned with and secured with respect to a portion of the existing rail and a second guide member angled with respect to the first guide member at a turnout angle. The second guide member is aligned with a portion of a turnout rail to allow the turnout rail to be provided with supporting pot sleepers, such that the desired gauge between the turnout rails is maintained. Also provided are a rectangular gauge spacing apparatus, a shear plate arrangement for providing supported engagement between first and second sections of rail, and a support framework for supporting a planar supporting member spanning over an existing rail.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: A high pressure tool assembly includes a tool and a hand control valve connected to the tool. A hydraulic manifold is fluidly connected to the hand control valve. An intensifier is fluidly connected to the hydraulic manifold and to the tool. The intensifier increases the pressure of a first operating fluid supplied to the tool. A first fluid circuit is formed between the hand control valve, the hydraulic manifold and the intensifier. The first fluid circuit operates at a first pressure. A second fluid circuit is formed between the intensifier and the tool and operates at a second pressure. The second pressure is larger than the first pressure. The second fluid circuit is isolated from the first fluid circuit.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the IIIF hydroxylase with a substrate. Modulators of IIIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the IIIF hydroxylase with a substrate. Modulators of IIIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the IIIF hydroxylase with a substrate. Modulators of IIIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the IIIF hydroxylase with a substrate. Modulators of IIIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: A high pressure tool assembly includes a hand control valve mechanically connectable to a tool. An intensifier is fluidly connected to the hand control valve and to the tool. The intensifier increases pressure of an operating fluid to be supplied to the tool. A first fluid circuit conveying the first operating fluid is formed between the intensifier and the tool. A second fluid circuit conveying a second operating fluid is formed between the hand control valve and the intensifier. The first fluid circuit operates at a first pressure. The second fluid circuit operates at a second pressure. The first pressure is higher than the second pressure. The first fluid circuit is isolated from the second fluid circuit.

Abstract: A base assembly removably and adjustably receives a tool and includes a base and a wall extending outwardly from the base. First and second openings are disposed in the wall. First and second cutouts are disposed in the wall to receive the tool. A pivot pin is removably received by the first and second openings. The tool is removably disposed on the pivot pin. A locking ring is disposed on the pivot pin. The locking ring is in a locked position to prevent movement of the pivot pin and in an unlocked position to allow movement of the pivot pin, thereby allowing the tool to be easily moved between positions and securely locked in a desired position.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID No. 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: A high pressure tool assembly includes a tool and a hand control valve connected to the tool. A hydraulic manifold is fluidly connected to the hand control valve. An intensifier is fluidly connected to the hydraulic manifold and to the tool. The intensifier increases the pressure of a first operating fluid supplied to the tool. A first fluid circuit is formed between the hand control valve, the hydraulic manifold and the intensifier. The first fluid circuit operates at a first pressure. A second fluid circuit is formed between the intensifier and the tool and operates at a second pressure. The second pressure is larger than the first pressure. The second fluid circuit is isolated from the first fluid circuit.