Patents by Inventor Henry Bennett
Henry Bennett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11958809Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.Type: GrantFiled: September 24, 2021Date of Patent: April 16, 2024Assignee: CYTOKINETICS, INC.Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn D. Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven M. Mennen, Jacqueline C. S. Woo, Bradley Paul Morgan, Alex Muci
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Patent number: 11944431Abstract: A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor.Type: GrantFiled: November 22, 2021Date of Patent: April 2, 2024Assignee: Masimo CorportationInventors: Matthew J. Schurman, Phillip William Wallace, Walter J. Shakespeare, Howard P. Apple, William Henry Bennett
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Publication number: 20240101517Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.Type: ApplicationFiled: November 27, 2023Publication date: March 28, 2024Inventors: Sheng CUI, Henry MORRISON, Karthik NAGAPUDI, Shawn D. WALKER, Charles BERNARD, Karl Bennett HANSEN, Neil Fred LANGILLE, Alan Martin ALLGEIER, Steven MENNEN, Jacqueline C.S. WOO, Bradley Paul MORGAN, Alex MUCI (DECEASED)
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Publication number: 20230248277Abstract: Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis.Type: ApplicationFiled: April 18, 2023Publication date: August 10, 2023Inventors: Walter J. Shakespeare, William Henry Bennett, Jason T. Iceman, Howard P. Apple, Phillip William Wallace, Matthew J. Schurman
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Patent number: 11660028Abstract: Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis.Type: GrantFiled: June 1, 2021Date of Patent: May 30, 2023Assignee: Masimo CorporationInventors: Walter J. Shakespeare, William Henry Bennett, Jason T. Iceman, Howard P. Apple, Phillip William Wallace, Matthew J. Schurman
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Patent number: 11426104Abstract: The present invention relates to a method and system for estimating blood analyte levels using a noninvasive optical coherence tomography (OCT) based physiological monitor. An algorithm correlates OCT-based estimated blood analyte data with actual blood analyte data determined by other methods, such as invasively. OCT-based data is fit to the obtained blood analyte measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood analyte levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based physiological monitor can be calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method.Type: GrantFiled: August 28, 2020Date of Patent: August 30, 2022Assignee: Masimo CorporationInventors: Matthew J. Schurman, Walter J. Shakespeare, William Henry Bennett
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Publication number: 20220142517Abstract: A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor.Type: ApplicationFiled: November 22, 2021Publication date: May 12, 2022Inventors: Matthew J. Schurman, Phillip William Wallace, Walter J. Shakespeare, Howard P. Apple, William Henry Bennett
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Patent number: 11207007Abstract: A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor.Type: GrantFiled: March 26, 2019Date of Patent: December 28, 2021Assignee: Masimo CorporationInventors: Matthew J. Schurman, Phillip William Wallace, Walter J. Shakespeare, Howard P. Apple, William Henry Bennett
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Publication number: 20210282679Abstract: Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis.Type: ApplicationFiled: June 1, 2021Publication date: September 16, 2021Inventors: Walter J. Shakespeare, William Henry Bennett, Jason T. Iceman, Howard P. Apple, Phillip William Wallace, Matthew J. Schurman
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Patent number: 11033210Abstract: Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis.Type: GrantFiled: October 31, 2017Date of Patent: June 15, 2021Assignee: Masimo CorporationInventors: Walter J. Shakespeare, William Henry Bennett, Jason T. Iceman, Howard P. Apple, Phillip William Wallace, Matthew J. Schurman
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Publication number: 20200390374Abstract: The present invention relates to a method and system for estimating blood analyte levels using a noninvasive optical coherence tomography (OCT) based physiological monitor. An algorithm correlates OCT-based estimated blood analyte data with actual blood analyte data determined by other methods, such as invasively. OCT-based data is fit to the obtained blood analyte measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood analyte levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based physiological monitor can be calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method.Type: ApplicationFiled: August 28, 2020Publication date: December 17, 2020Inventors: Matthew J. Schurman, Walter J. Shakespeare, William Henry Bennett
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Patent number: 10791971Abstract: The present invention relates to a method and system for estimating blood analyte levels using a noninvasive optical coherence tomography (OCT) based physiological monitor. An algorithm correlates OCT-based estimated blood analyte data with actual blood analyte data determined by other methods, such as invasively. OCT-based data is fit to the obtained blood analyte measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood analyte levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based physiological monitor can be calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method.Type: GrantFiled: October 4, 2018Date of Patent: October 6, 2020Assignee: Masimo CorporationInventors: Matthew J. Schurman, Walter J. Shakespeare, William Henry Bennett
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Publication number: 20190216370Abstract: A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor.Type: ApplicationFiled: March 26, 2019Publication date: July 18, 2019Inventors: Matthew J. Schurman, Phillip William Wallace, Walter J. Shakespeare, Howard P. Apple, William Henry Bennett
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Patent number: 10278626Abstract: A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor.Type: GrantFiled: February 15, 2018Date of Patent: May 7, 2019Assignee: MASIMO CORPORATIONInventors: Matthew J. Schurman, Phillip William Wallace, Walter J. Shakespeare, Howard P. Apple, William Henry Bennett
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Patent number: 10267708Abstract: A balance has a balance centerline and an axial force measurement section having a longitudinal slot partially dividing the axial force measurement section into a first part and a second part longitudinally overlapping each other and interconnected by corner flexure groups. The axial force measurement section has an axial force measurement beam located approximately midway between the corner flexure groups. The axial force measurement beam has strain gages for determining axial force on the model. Each corner flexure group includes flexures each having a first flexure root and a second flexure root respectively joined to the first part and the second part. The flexures each have a flexure midpoint between the first and second flexure roots, and a flexure thickness that is tapered along the flexure length from each of the first and second flexure roots to a reduced thickness proximate the flexure midpoint.Type: GrantFiled: May 18, 2017Date of Patent: April 23, 2019Assignee: The Boeing CompanyInventors: Seth Skube, Henry Bennett
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Publication number: 20190029574Abstract: The present invention relates to a method and system for estimating blood analyte levels using a noninvasive optical coherence tomography (OCT) based physiological monitor. An algorithm correlates OCT-based estimated blood analyte data with actual blood analyte data determined by other methods, such as invasively. OCT-based data is fit to the obtained blood analyte measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood analyte levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based physiological monitor can be calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method.Type: ApplicationFiled: October 4, 2018Publication date: January 31, 2019Inventors: Matthew J. Schurman, Walter J. Shakespeare, William Henry Bennett
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Publication number: 20180335364Abstract: A balance has a balance centerline and an axial force measurement section having a longitudinal slot partially dividing the axial force measurement section into a first part and a second part longitudinally overlapping each other and interconnected by corner flexure groups. The axial force measurement section has an axial force measurement beam located approximately midway between the corner flexure groups. The axial force measurement beam has strain gages for determining axial force on the model. Each corner flexure group includes flexures each having a first flexure root and a second flexure root respectively joined to the first part and the second part. The flexures each have a flexure midpoint between the first and second flexure roots, and a flexure thickness that is tapered along the flexure length from each of the first and second flexure roots to a reduced thickness proximate the flexure midpoint.Type: ApplicationFiled: May 18, 2017Publication date: November 22, 2018Inventors: Seth Skube, Henry Bennett
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Patent number: 10130291Abstract: The present invention relates to a method and system for estimating blood analyte levels using a noninvasive optical coherence tomography (OCT) based physiological monitor. An algorithm correlates OCT-based estimated blood analyte data with actual blood analyte data determined by other methods, such as invasively. OCT-based data is fit to the obtained blood analyte measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood analyte levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based physiological monitor can be calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method.Type: GrantFiled: May 25, 2017Date of Patent: November 20, 2018Assignee: MASIMO CORPORATIONInventors: Matthew J. Schurman, Walter J. Shakespeare, William Henry Bennett
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Publication number: 20180249933Abstract: A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor.Type: ApplicationFiled: February 15, 2018Publication date: September 6, 2018Inventors: Matthew J. Schurman, Phillip William Wallace, Walter J. Shakespeare, Howard P. Apple, William Henry Bennett
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Patent number: 9924893Abstract: A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor.Type: GrantFiled: August 4, 2014Date of Patent: March 27, 2018Assignee: MASIMO CORPORATIONInventors: Matthew J. Schurman, Phillip William Wallace, Walter J. Shakespeare, Howard P. Apple, William Henry Bennett