Abstract: A method and devices for localized delivery of a chemotherapeutic agent to solid tumors, wherein the agent does not cross the blood-brain barrier and is characterized by poor bioavailability and/or short half-lives in vivo, are described. The devices consist of reservoirs which release drug over an extended time period while at the same time preserving the bioactivity and bioavailability of the agent. In the most preferred embodiment, the device consists of biodegradable polymeric matrixes, although reservoirs can also be formulated from non-biodegradable polymers or reservoirs connected to implanted infusion pumps. The devices are implanted within or immediately adjacent the tumors to be treated or the site where they have been surgically removed. The examples demonstrate the efficacy of paclitaxel and camptothecin delivered in polymeric implants prepared by compression molding of biodegradable and non-biodegradable polymers, respectively. The results are highly statistically significant.

Abstract: A drive mechanism for a reciprocating and multiple step index mechanism to achieve smooth starting and stopping action with controlled acceleration and decleration. It is characterized by extremely flexible kinematic characteristics achieved by the superposition of a constant velocity, fundamental and a higher harmonic component. The mechanism utilizes pairs of rotating drive members and eccentric members mounted in non-rotational relation, the pairs being connected to rotate in a multiple integral angular velocity ratio. An output member is arranged in driving relation to one of the eccentric members and is influenced also by the rotation of the other eccentric member. Power input is directed to one of the pairs of drive members.

Abstract: An intermittent reversible indexing system with a rotary input and rotary output which includes a natural dwell of the output at the end of each cycle with a smooth acceleration to a maximum velocity and subsequent deceleration to another dwell and a simple mechanism for changing the index stroke. A planetary carrier carrying a single planetary gear is driven about a first axis with the planetary gear in mesh with a stationary sun gear concentric about said first axis. A drive member in the form of a shaft eccentric to the axis of said planetary engages and slides in a slot of an output member, thereby driving said output member about a second axis displaced from said first axis. A movable mount for the output member changes the drive relationship with said eccentric shaft to change the index motion.

Abstract: An internal combustion engine construction to improve thermodynamic efficiency by providing, in addition to the standard cylinders and pistons, a supplemental cylinder connected to each combustion chamber of each cylinder and, a piston in each supplemental cylinder associated to move in conjunction with the standard pistons, the relationship of the association being such that the volume of the combustion chamber can be enlarged or ensmalled either by a manual control or an automatic control regulable in response to engine conditions and to modify the volume time relationship.

Abstract: A multiple step indexing mechanism having a rotary input and a rotary output and intermediate driving members with driving connections to generate a periodic dwell interval of the output member through the kinematic superposition of substantially linear and substantially harmonic motion components including those which include multiple harmonic components together with a dwell extension mechanism which includes timing means driven by the input member, a device for engaging and disengaging one of the driving connections, and a connection between the timing means and engagement device to effect disengagement within one of the periodic dwell intervals and re-engagement within another of the periodic dwell intervals.