Patents by Inventor Henry C. Lai

Henry C. Lai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins and methods of use
    Patent number: 8048850
    Abstract: In one aspect, the invention provides covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins. In some embodiments, the covalent conjugates comprise artelinate and holotransferrin. In another aspect, the invention provides methods for administering the covalent conjugates of the invention to treat cancer and infections by pathogens that bind iron-carrying proteins.
    Type: Grant
    Filed: June 6, 2003
    Date of Patent: November 1, 2011
    Assignee: University of Washington
    Inventors: Henry C. Lai, Tomikazu Sasaki, Narendra P. Singh
  • METHODS OF USING ARTEMISININ-LIKE COMPOUNDS TO PREVENT OR DELAY THE APPEARANCE OF CANCER
    Publication number: 20080119542
    Abstract: The invention provides methods for preventing or delaying the development of cancer by administering free radical-generating agents to a subject. Representative free radical-generating agents include endoperoxide compounds, such as endoperoxides bearing sesquiterpene compounds such as artemisinin and its analogs, arteflene and its analogs, 1,2,4-trioxanes and 1,2,4,5-tetraoxanes. Intracellular iron concentrations may be enhanced by the administration of iron salts or complexes.
    Type: Application
    Filed: November 30, 2007
    Publication date: May 22, 2008
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Henry C. Lai, Narendra P. Singh
  • Covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins and methods of use
    Publication number: 20040067875
    Abstract: In one aspect, the invention provides covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins. In some embodiments, the covalent conjugates comprise artelinate and holotransferrin. In another aspect, the invention provides methods for administering the covalent conjugates of the invention to treat cancer and infections by pathogens that bind iron-carrying proteins.
    Type: Application
    Filed: June 6, 2003
    Publication date: April 8, 2004
    Applicant: University of Washington
    Inventors: Henry C. Lai, Tomikazu Sasaki, Narendra P. Singh
  • Methods of using artemisinin-like compounds to prevent or delay the appearance of cancer
    Publication number: 20040058981
    Abstract: The invention provides methods for preventing or delaying the development of cancer by administering free radical-generating agents to a subject. Representative free radical-generating agents include endoperoxide compounds, such as endoperoxides bearing sesquiterpene compounds such as artemisinin and its analogs, arteflene and its analogs, 1,2,4-trioxanes and 1,2,4,5-tetraoxanes. Intracellular iron concentrations may be enhanced by the administration of iron salts or complexes.
    Type: Application
    Filed: June 6, 2003
    Publication date: March 25, 2004
    Applicant: University of Washington
    Inventors: Henry C. Lai, Narendra P. Singh
  • Methods of inhibition or killing cancer cells using an endoperoxide
    Patent number: 5578637
    Abstract: Methods of inhibiting or killing cancer cells are disclosed wherein compounds having an endoperoxide moiety that is reactive with heme are administered under conditions which enhance intracellular iron concentrations. Representative endoperoxide compounds include endoperoxide bearing sesquiterpene compounds such as artemisinin and its analogs, arteflene and its analogs, 1,2,4-trioxanes and 1,2,4,5-tetraoxanes. Intracellular iron concentrations may be enhanced by the administration of iron salts or complexes.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: November 26, 1996
    Assignee: University of Washington
    Inventors: Henry C. Lai, Narendra P. Singh