Abstract: The present disclosure provides methods and compositions comprising IL-21 polypeptides, targeted cytokine construct that selectively activates target immune cells (e.g., CD8+ T cells) over other immune cell types. The cytokine of the present disclosure can further comprise mutations that alter its charge distribution to improve its half-life within the blood.

Abstract: The present disclosure provides methods and compositions comprising IL-21 polypeptides, targeted cytokine construct that selectively activates target immune cells (e.g., CD8+ T cells) over other immune cell types. The cytokine of the present disclosure can further comprise mutations that alter its charge distribution to improve its half-life within the blood.

Abstract: Provided herein are anti-CD8 antigen binding molecules and fusion polypeptides comprising the CD8 antigen binding molecules for selectively modulating the function of CD8+ T cells over other immune cells. In addition, the present disclosure also provides polynucleotides encoding the disclosed antigen binding molecules and fusion polypeptides, and vectors and host cells comprising such polynucleotides. The present disclosure further provides methods for producing the antigen binding molecules and fusion polypeptides, pharmaceutical compositions comprising the same, and uses thereof.

Abstract: A data transfer control apparatus includes a channel controller and plural transfer controllers. The channel controller receives, prioritizes and queues data transfer requests. An event to transfer controller table enables recall of a transfer controller number corresponding to the data transfer request. The plural transfer controllers are independent and can operate simultaneously in parallel. Each transfer controller includes a read bus interface and a write bus interface which arbitrate with other bus masters in the case of blocking accesses directed to interfering devices or address ranges.

Abstract: A data transfer control apparatus includes a channel controller and a transfer controller. The channel controller receives, prioritizes and queues data transfer requests. The transfer controller includes separate control of data source and data destination in a data transfer corresponding to the data transfer requests. The transfer controller includes a data transfer program register and active source and destination registers. The transfer controller operates from the active source and destination registers. Upon completion of a data transfer the transfer controller writes data transfer parameters from the data transfer program register to the active source and destination registers.