Abstract: The present invention is directed to compounds which suppress immune responses and/or selectivly inhibit complement. These compounds contain an aromatic ring and are substituted dihydrobenzofurans, spirobenzofuran-2(3H)-cycloalkanes, and their open chain intermediates. The compounds of the present invention, and the phamaceutically acceptable salts thereof, interrupt the proteolytic processing of C5 to bioactive components, exhibit immunosuppressive activites, and have therapeutic utility in the amelioration of disease and disorders mediated by complement and/or immune activity.

Abstract: A temperature controller and alarm device for use with a cartridge heater of the general type providing heat within a mold in a plastic injection molding apparatus includes an amplifier for sensing voltage signals developed by a thermocouple within the cartridge and which signal is representative of the temperature produced by the heater. The heater temperature is compared to a desired temperature and a signal proportional to the difference in temperature is coupled to a comparator which produces an output signal when the magnitude of a triangular signal exceeds the magnitude of the difference signal to cause the comparator to operate switches which connect and disconnect a DELTA configured three-phase voltage source to and from both sides of the heating element. Visual and audible alarms are provided to indicate the occurrence of a thermocouple open circuit fault condition, a heating element open circuit fault condition and a heating element short circuit fault condition.