Patents by Inventor Henry E. Auer

Henry E. Auer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Device for the sustained release of aggregation-stabilized, biologically active agent
    Publication number: 20030133979
    Abstract: A device for the sustained release in vivo of a water soluble, biologically active agent wherein the agent is susceptible to aggregation comprising a drug delivery device and aggregation-stabilized, biologically active agent wherein the aggregation-stabilized agent is disposed within the drug delivery device.
    Type: Application
    Filed: October 22, 2002
    Publication date: July 17, 2003
    Applicant: Alkermes Controlled Therapeutics, Inc.
    Inventors: Paul A. Burke, Stephen E. Zale, Mark A. Tracy, OluFunmi Lily Johnson, Howard Bernstein, M. Amin Khan, Avram Brickner, Henry E. Auer
  • Process for producing small particles of biologically active molecules
    Patent number: 6569458
    Abstract: Small diameter particles of biologically active molecules are produced by atomizing solutions of the molecules through a nozzle into very cold liquified gases, which immediately freeze the atomized droplets. The resulting frozen particles having diameters of approximately 10 to 90 micrometers are lyophilized to produce porous particles, suspended in a non-solvent for the molecules, and exposed to ultrasonic energy or homogenization to produce particles having diameters of 0.1 to 10 micrometers with greater than 70 to 95% of the initial biological activity of the molecules in solution.
    Type: Grant
    Filed: January 21, 1993
    Date of Patent: May 27, 2003
    Assignee: Alkermes Controlled Therapeutics, Inc.
    Inventors: Wayne R. Gombotz, Michael S. Healy, Larry R. Brown, Henry E. Auer
  • Device for the sustained release of aggregation-stabilized, biologically active agent
    Patent number: 6514533
    Abstract: A device for the sustained release in vivo of a water soluble, biologically active agent wherein the agent is susceptible to aggregation comprising a drug delivery device and aggregation-stabilized, biologically active agent wherein the aggregation-stabilized agent is disposed within the drug delivery device.
    Type: Grant
    Filed: September 22, 1997
    Date of Patent: February 4, 2003
    Assignee: Alkermas Controlled Therapeutics, Inc.
    Inventors: Paul A. Burke, Stephen E. Zale, Mark A. Tracy, OluFunmi Lily Johnson, Howard Bernstein, M. Amin Khan, Henry E. Auer
  • Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof
    Patent number: 5849694
    Abstract: The present invention provides a stable and bioactive recombinant small-loop modified somatotropin which has its small-loop cysteines changed to other amino acids or deleted altogether and a method for producing such a small-loop modified somatotropin. Also provided by the present invention are DNA sequences coding for such small-loop modified somatotropins, plasmids containing such sequences, and organisms containing such plasmids. Furthermore, pharmaceutical compositions including small-loop modified somatotropins and methods for using such pharmaceutical compositions are disclosed.
    Type: Grant
    Filed: July 16, 1990
    Date of Patent: December 15, 1998
    Inventors: Richard M. Synenki, Peter M. Rubinelli, Henry E. Auer, James E. Seely
  • Method for removing sodium dodecyl sulfate from sodium dodecyl sulfate solubilized protein solutions
    Patent number: 4801691
    Abstract: Guanidine hydrochloride (GCl) is used to remove excess sodium dodecyl sulfate (SDS) from SDS-solubilized protein solutions, and particularly from SDS-solubilized inclusion body solutions, GCl is added to the solution containing SDS to induce the formation of a GCl-SDS complex (GDS) which, when allowed to precipitate, can easily be removed by centrifugation, filtration, or other suitable means.
    Type: Grant
    Filed: May 15, 1987
    Date of Patent: January 31, 1989
    Assignee: International Minerals & Chemical Corp.
    Inventor: Henry E. Auer