Patents by Inventor Henry Erlich

Henry Erlich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-invasive early detection of solid organ transplant rejection by quantitative analysis of mixtures by deep sequencing of HLA gene amplicons using next generation systems
    Patent number: 9752189
    Abstract: The invention is a method of detecting or assessing solid organ graft (transplant) rejection by detecting donor-specific HLA alleles in a blood sample of a graft (transplant) recipient. The invention further comprises a method of detecting the presence of maternal cells in a blood sample of an offspring.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: September 5, 2017
    Assignees: Roche Molecular Systems, Inc., The Scripps Research Institute
    Inventors: Henry Erlich, Bryan Hoglund, Cherie Holcomb, Priscilla Moonsamy, Nick Newton, Melinda Rastrou, Nancy Schoenbrunner, Alison Tsan, Daniel Salomon
  • NON-INVASIVE EARLY DETECTION OF SOLID ORGAN TRANSPLANT REJECTION BY QUANTITATIVE ANALYSIS OF HLA GENE AMPLICONS
    Publication number: 20160017421
    Abstract: The invention is a method of detecting or assessing solid organ graft (transplant) rejection and acute dysfunction—no rejection condition by detecting donor-specific HLA alleles in a blood sample of a graft (transplant) recipient.
    Type: Application
    Filed: November 3, 2014
    Publication date: January 21, 2016
    Inventors: Henry Erlich, Bryan Hoglund, Cherie Holcomb, Priscilla Moonsamy, Nick Newton, Melinda Rastrou, Daniel Salomon, Nancy Shoenbrunner, Alison Tsan
  • METHOD OF DETERMINING THE FRACTION OF FETAL DNA IN MATERNAL BLOOD USING HLA MARKERS
    Publication number: 20150203914
    Abstract: The invention comprises a method of determining the fraction of fetal DNA in maternal blood or plasma using HLA locus wherein the maternal and fetal HLA alleles are detected and quantified by clonal or digital methods.
    Type: Application
    Filed: May 9, 2014
    Publication date: July 23, 2015
    Applicant: Roche Molecular Systems
    Inventors: Henry Erlich, Bryan Hoglund, Cherie Holcomb, Priscilla Moonsamy, Nick Newton, Melinda Rastrou, Nancy Schoenbrunner, Alison Tsan
  • NON-INVASIVE EARLY DETECTION OF SOLID ORGAN TRANSPLANT REJECTION BY QUANTITATIVE ANALYSIS OF MIXTURES BY DEEP SEQUENCING OF HLA GENE AMPLICONS USING NEXT GENERATION SYSTEMS
    Publication number: 20140336056
    Abstract: The invention is a method of detecting or assessing solid organ graft (transplant) rejection by detecting donor-specific HLA alleles in a blood sample of a graft (transplant) recipient. The invention further comprises a method of detecting the presence of maternal cells in a blood sample of an offspring.
    Type: Application
    Filed: May 8, 2014
    Publication date: November 13, 2014
    Applicants: Roche Molecular Systems, The Scripps Research Institute
    Inventors: Henry Erlich, Bryan Hoglund, Cherie Holcomb, Priscilla Moonsamy, Nick Newton, Melinda Rastrou, Nancy Schoenbrunner, Alison Tsan, Daniel Salomon
  • Methods and Compositions for Very High Resolution Genotyping of HLA
    Publication number: 20140141436
    Abstract: The invention is a method of determining HLA genotype for HLA-A, HLA-B, HLA-C, DQB1, DRB1, DRB3, DRB4, DRB5, DPA1 and DPB1. Reagents and kits are also disclosed.
    Type: Application
    Filed: August 21, 2013
    Publication date: May 22, 2014
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Henry Erlich, Bryan Hoglund, Cherie Holcomb, Priscilla Moonsamy
  • HIGH RESOLUTION, HIGH THROUGHPUT HLA GENOTYPING BY CLONAL SEQUENCING
    Publication number: 20100086914
    Abstract: The invention provides methods and reagent for performing full, multi-locus HLA genotyping for multiple individuals in a single sequencing run using clonal sequencing.
    Type: Application
    Filed: October 3, 2008
    Publication date: April 8, 2010
    Inventors: Gordon BENTLEY, Henry Erlich, Russell Higuchi
  • Detection of susceptibility to autoimmune diseases
    Publication number: 20070105146
    Abstract: The present invention provides methods and reagents for determining sequence variants present at the IL4 receptor, IL-4 and IL-13 loci, which facilitate identifying individuals at risk for type 1 diabetes.
    Type: Application
    Filed: December 11, 2006
    Publication date: May 10, 2007
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Daniel Mirel, Henry Erlich, Teodorica Bugawan, Janelle Noble, Ana Valdes