Patents by Inventor Henry Friedman

Henry Friedman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NEOADJUVANT CANCER TREATMENT
    Publication number: 20250241969
    Abstract: Provided is a method of treating a tumor in an individual by neoadjuvant therapy, wherein the individual has not previously undergone treatment to effectively reduce tumor burden, the method comprising administering an oncolytic chimeric poliovirus construct, or an oncolytic chimeric poliovirus construct and an immune checkpoint inhibitor, followed by reduction of the tumor. The method may further comprise administration of immune checkpoint inhibitor or oncolytic chimeric poliovirus construct following reduction of tumor. Kits for performing the methods are also provided.
    Type: Application
    Filed: March 3, 2025
    Publication date: July 31, 2025
    Inventors: Darell Bigner, Matthias Gromeier, Smita Nair, Henry Friedman, Annick Desjardins
  • NEOADJUVANT CANCER TREATMENT
    Publication number: 20210106633
    Abstract: Provided is a method of treating a tumor in an individual by neoadjuvant therapy, wherein the individual has not previously undergone treatment to effectively reduce tumor burden, the method comprising administering an oncolytic chimeric poliovirus construct, or an oncolytic chimeric poliovirus construct and an immune checkpoint inhibitor, followed by reduction of the tumor. The method may further comprise administration of immune checkpoint inhibitor or oncolytic chimeric poliovirus construct following reduction of tumor. Kits for performing the methods are also provided.
    Type: Application
    Filed: April 2, 2019
    Publication date: April 15, 2021
    Applicant: Duke University
    Inventors: Darell Bigner, Matthias Gromeier, Smita Nair, Henry Friedman, Annick Desjardins
  • 3-(5-Nitro-2-imidazolyl)pyrazoles
    Patent number: 4075222
    Abstract: There are disclosed novel 3-(5-nitro-2-imidazolyl)pyrazoles exhibiting utility as antibacterial, antiprotozoal, and antifungal agents, making the compounds useful particularly in veterinary medicine, especially in controlling bacterial and protozoal infections of cattle, swine, and poultry. The compounds are also active as growth promoters in chickens.
    Type: Grant
    Filed: May 6, 1976
    Date of Patent: February 21, 1978
    Assignee: Eli Lilly and Company
    Inventors: John Pomfret Verge, Martin Charles Neville, Henry Friedman
  • 3-[(5-nitro-2-imidazolyl)pyrazol-5-yl]oxamic acid derivatives
    Patent number: 4029671
    Abstract: There are disclosed novel 3-[(5-nitro-2-imidazolyl)pyrazol-5-yl]oxamic acid derivatives and salts thereof, exhibiting utility as antibacterial, antiprotozoal, and antifungal agents, making the compounds useful particularly in veterinary medicine, especially in controlling bacterial and protozoal infections of cattle, swine, and poultry.
    Type: Grant
    Filed: March 22, 1976
    Date of Patent: June 14, 1977
    Assignee: Eli Lilly and Company
    Inventors: Henry Friedman, Emily J. Canada
  • 3-(5-Nitroimidazol-2-yl)pyrazolo[3,4-d]pyrimidine compounds
    Patent number: 4001230
    Abstract: There are disclosed novel 3-(5-nitroimidazol-2-yl)-pyrazolo[3,4-d]pyrimidine compounds exhibiting utility as antibacterial and antiprotozoal agents.
    Type: Grant
    Filed: January 31, 1975
    Date of Patent: January 4, 1977
    Assignee: Eli Lilly and Company
    Inventor: Henry Friedman
  • Method for promoting growth of poultry with 3-(5-nitro-2-imidazolyl)pyrazoles
    Patent number: 3980794
    Abstract: There are disclosed novel 3-(5-nitro-2-imidazolyl)-pyrazoles exhibiting utility as antibacterial, antiprotozoal, and antifungal agents, making the compounds useful particularly in veterinary medicine, especially in controlling bacterial and protozoal infections of cattle, swine, and poultry. The compounds are also active as growth promoters in chickens.
    Type: Grant
    Filed: March 14, 1975
    Date of Patent: September 14, 1976
    Assignee: Eli Lilly and Company
    Inventors: John Pomfret Verge, Martin Charles Neville, Henry Friedman
  • 3-(5-Nitro-2-imidazolyl) pyrazoles
    Patent number: 3947467
    Abstract: There are disclosed novel 3-(5-nitro-2-imidazolyl)-pyrazoles exhibiting utility as antibacterial, antiprotozoal, and antifungal agents, making the compounds useful particularly in veterinary medicine, especially in controlling bacterial and protozoal infections of poultry and swine. The compounds are also active as growth promoters in chickens.
    Type: Grant
    Filed: May 13, 1974
    Date of Patent: March 30, 1976
    Assignee: Eli Lilly and Company
    Inventors: John Pomfret Verge, Martin Charles Neville, Henry Friedman