Publication number: 20080287521
Abstract: Novel crystalline forms of [R-(R*,R*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt designated Form V, Form VI, Form VII, Form VIII, Form IX, Form X, Form XI, Form XII, Form XIII, Form XIV, Form XV, Form XVI, Form XVII, Form XVIII, and Form XIX are characterized by their X-ray powder diffraction, solid-state NMR, and/or Raman spectroscopy are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, and Alzheimer's disease.
Type:
Application
Filed:
July 14, 2008
Publication date:
November 20, 2008
Inventors:
Stephen Robert Byrn, David Andrew Coates, Karen Sue Gushurst, Joseph Francis Krzyzaniak, Zheng Jane Li, Henry Grant Morrison, II, Aeri Park, Petinka Ivanova Vlahova
Patent number: 7144915
Abstract: Novel crystalline forms of [R-(R*,R*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt designated Form V, Form VI, Form VII, Form VIII, Form IX, Form X, Form XI, Form XII, Form XIII, Form XIV, Form XV, Form XVI, Form XVII, Form XVIII, and Form XIX are characterized by their X-ray powder diffraction, solid-state NMR, and/or Raman spectroscopy are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, and Alzheimer's disease.
Type:
Grant
Filed:
June 6, 2003
Date of Patent:
December 5, 2006
Assignee:
Warner-Lambert Company, LLC
Inventors:
Stephen Robert Byrn, David Andrew Coates, Karen Sue Gushurst, Joseph Francis Krzyzaniak, Zheng Jane Li, Henry Grant Morrison, II, Aeri Park, Petinka Ivanova Vlahova
Patent number: 6605729
Abstract: Novel crystalline forms of [R-(R*,R*)]-2-(4-fluorophenyl)-&bgr;,&dgr;-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt designated Form V, Form VI, Form VII, Form VIII, Form IX, Form X, Form XI, Form XII, Form XIII, Form XIV, Form XV, Form XVI, Form XVII, Form XVIII, and Form XIX are characterized by their X-ray powder diffraction, solid-state NMR, and/or Raman spectroscopy are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, and Alzheimer's disease.
Type:
Grant
Filed:
June 28, 2002
Date of Patent:
August 12, 2003
Assignee:
Warner-Lambert Company
Inventors:
Stephen Robert Byrn, David Andrew Coates, Karen Sue Gushurst, Joseph Francis Krzyzaniak, Zheng Jane Li, Henry Grant Morrison, II, Aeri Park, Petinka Ivanova Vlahova