Patents by Inventor Henry H. Gu

Henry H. Gu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Acridone inhibitors of IMPDH enzyme
    Patent number: 7312209
    Abstract: Compounds having the formula (I), wherein R3 is selected from H, OH and NH2; R30 is selected from ?O and ?S; W is —C(?O)—, —S(?O)—, or —S(O)2—; or W may be —CH2— if X is —C(?O)—; X is selected from —CH2—, —N(R4)—, and —O—, except that when W is —CH2—, X is —C(?O)—; Y is a bond or —C(R40)(R45)—; Q is a linker; Z is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl; and R1, R2, R24, and R25 are as defined in the specification.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: December 25, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Edwin J. Iwanowicz, Scott H. Watterson, Ping Chen, T. G. Murali Dhar, Henry H. Gu, Yufen Zhao
  • Inhibitors of IMPDH enzyme
    Patent number: 7205324
    Abstract: The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5?-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH associated disorders, such as transplant rejection and autoimmune diseases.
    Type: Grant
    Filed: June 19, 2003
    Date of Patent: April 17, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Henry H. Gu, T. G. Murali Dhar, Edwin J. Iwanowicz
  • Inhibitors of IMPDH enzyme
    Patent number: 7060720
    Abstract: The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5?-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH associated disorders, such as transplant rejection and autoimmune diseases.
    Type: Grant
    Filed: November 19, 2003
    Date of Patent: June 13, 2006
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Henry H. Gu, T. G. Murali Dhar, Edwin J. Iwanowicz
  • Inhibitors of IMPDH enzyme
    Patent number: 7053111
    Abstract: The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5?-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH associated disorders, such as transplant rejection and autoimmune diseases.
    Type: Grant
    Filed: June 19, 2003
    Date of Patent: May 30, 2006
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Henry H. Gu, T. G. Murali Dhar, Edwin J. Iwanowicz
  • Heterocycles that are inhibitors of IMPDH enzyme
    Patent number: 6919335
    Abstract: Compounds of the formula wherein X1 is C(O), —S(O)—, or —S(O)2—; X2 is CR3 or N; X3 is —NH—, —O—, or —S—; X4 is CR4 or N; X5 is CR5 or N; and X6 is CR6 or N are useful as inhibitors of IMPDH enzyme. Thus, these compounds can be used as therapeutic agents for IMPDH-associated disorders.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: July 19, 2005
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Edwin J. Iwanowicz, Scott H. Watterson, T. G. Murali Dhar, William J. Pitts, Henry H. Gu
  • Novel inhibitors of IMPDH enzyme
    Publication number: 20040102497
    Abstract: The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5′-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH associated disorders, such as transplant rejection and autoimmune diseases.
    Type: Application
    Filed: November 19, 2003
    Publication date: May 27, 2004
    Inventors: Henry H. Gu, T.G. Murali Dhar, Edwin J. Iwanowicz
  • Novel inhibitors of IMPDH enzyme
    Publication number: 20040082562
    Abstract: The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5′-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH associated disorders, such as transplant rejection and autoimmune diseases.
    Type: Application
    Filed: June 19, 2003
    Publication date: April 29, 2004
    Inventors: Henry H. Gu, T.G. Murali Dhar, Edwin J. Iwanowicz
  • Acridone inhibitors of IMPDH enzyme
    Publication number: 20040053955
    Abstract: Compounds having the formula (I), 1
    Type: Application
    Filed: December 20, 2002
    Publication date: March 18, 2004
    Inventors: Edwin J. Iwanowicz, Scott H. Watterson, Ping Chen, T. G. Murali Dhar, Henry H. Gu, Yufen Zhao
  • Amide and diamide inhibitors of IMPDH enzyme for use in treating IMPDH-associated disorders
    Patent number: 6624184
    Abstract: The present invention discloses the identification of the inhibitors of IMPDH (inosine-5′-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH associated disorders, such as transplant rejection and autoimmune diseases.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: September 23, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Henry H. Gu, T. G. Murali Dhar, Edwin J. Iwanowicz
  • Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
    Patent number: 6596747
    Abstract: Compounds having the formula (I), are effective as inhibitors of IMPDH enzyme and/or serine protease Factor VIIa, wherein B is a monocyclic or bicyclic carbocyclic or heterocyclic ring, D is a monocyclic or bicyclic carbocyclic or heterocyclic ring except when A is a heterocyclic ring, then D is a heterocyclic ring system, R is hydrogen or C1-4alkyl, and A, R1, R2 and R4 are as defined in the specification.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: July 22, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Chunjian Liu, T. G. Murali Dhar, Henry H. Gu, Edwin J. Iwanowicz, Katerina Leftheris, William J. Pitts, Timothy F. Herpin, Gregory S. Bisacchi
  • Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
    Publication number: 20020143176
    Abstract: Compounds having the formula (I), 1
    Type: Application
    Filed: November 29, 2001
    Publication date: October 3, 2002
    Inventors: Chunjian Liu, T.G. Murali Dhar, Henry H. Gu, Edwin J. Iwanowicz, Katerina Leftheris, William J. Pitts, Timothy F. Herpin, Zulan Pi, Gregory S. Bisacchi
  • Compounds derived from an amine nucleus that are inhibitors of IMPDH enzyme
    Patent number: 6399773
    Abstract: The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5′-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH mediated diseases, such as transplant rejection and autoimmune diseases.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: June 4, 2002
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Chunjian Liu, T. G. Murali Dhar, Henry H. Gu, Edwin J. Iwanowicz, Katerina Leftheris, William J. Pitts
  • Heterocycles that are inhibitors of IMPDH enzyme
    Publication number: 20020040022
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: April 23, 2001
    Publication date: April 4, 2002
    Inventors: Edwin J. Iwanowicz, Scott H. Watterson, T.G. Murali Dhar, William J. Pitts, Henry H. Gu