Patents by Inventor Henry H. Holzgrefe

Henry H. Holzgrefe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • System and method for measuring ventricular function
    Patent number: 6743181
    Abstract: A system and method for measuring ventricular function in an isolated, perfused heart using an intraventricular balloon connected to a plumbing circuit containing a fluid, the plumbing circuit including (a) a valve for selectively opening the plumbing circuit to (i) atmospheric pressure or (ii) a pressure control circuit of a pressure control apparatus or (b) a pressure control apparatus which can be selectively connected to the plumbing circuit, including the steps of establishing a base pressure by (1) opening the valve to atmospheric pressure or the pressure control circuit or (2) operating the pressure control apparatus, after equalization of the pressure within the intraventricular balloon with the base pressure, closing the valve or stopping operation of the pressure control apparatus, following the closing of the valve, measuring ventricular function as a function of a titrated infusion of fluid into the plumbing circuit and intraventricular balloon, performing an intervention, and repeating at least t
    Type: Grant
    Filed: August 1, 2002
    Date of Patent: June 1, 2004
    Assignee: Bristol-Myers Squibb Co.
    Inventor: Henry H. Holzgrefe
  • System and method for measuring ventricular function
    Publication number: 20030036707
    Abstract: A system and method for measuring ventricular function in an isolated, perfused heart using an intraventricular balloon connected to a plumbing circuit containing a fluid, the plumbing circuit including (a) a valve for selectively opening the plumbing circuit to (i) atmospheric pressure or (ii) a pressure control circuit of a pressure control apparatus or (b) a pressure control apparatus which can be selectively connected to the plumbing circuit, including the steps of establishing a base pressure by (1) opening the valve to atmospheric pressure or the pressure control circuit or (2) operating the pressure control apparatus, after equalization of the pressure within the intraventricular balloon with the base pressure, closing the valve or stopping operation of the pressure control apparatus, following the closing of the valve, measuring ventricular function as a function of a titrated infusion of fluid into the plumbing circuit and intraventricular balloon, performing an intervention, and repeating at least t
    Type: Application
    Filed: August 1, 2002
    Publication date: February 20, 2003
    Inventor: Henry H. Holzgrefe
  • Vasopeptidase inhibitors to treat angina pectoris
    Patent number: 6140319
    Abstract: Vasopeptidaes inhibitors, especially omapatrilat, are useful in treating and/or relieving the symptoms of angina pectoris. The vasopeptidase inhibitor may be used in combination with other pharmaceutically active agents.
    Type: Grant
    Filed: March 16, 2000
    Date of Patent: October 31, 2000
    Assignee: Bristol-Myers Squibb Co.
    Inventors: James R. Powell, Henry H. Holzgrefe