Abstract: The present disclosure provides a combination therapy for treating, preventing, inhibiting, ameliorating, or delaying the onset of Friedreich's ataxia in a subject in need thereof comprising administering to the subject both elamipretide and omaveloxolone or pharmaceutically acceptable salts, stereoisomers, mixtures of stereoisomers, tautomers, hydrates, and/or solvates thereof. The present disclosure further provides an embodiment of a combination product suitable for administration to said subject.

Abstract: A membrane-based electroosmotic pump, having catalyst regions on electrodes, can pump a fluid without applying an external voltage. Chemical reactions of fluid components on the catalyst regions on the electrodes can induce an electric field that generates an electroosmotic flow through channels of the membrane. In one embodiment, a pump comprising platinum and gold electrodes can generate the flow of the fluid containing hydrogen peroxide through channels of the membrane. In another embodiment, a pump comprising gold electrodes, on which glucose oxidase and laccase are deposited, can generate the flow of the fluid containing glucose.

Abstract: Novel methods and structures are disclosed herein which employ pseudorandom sequences to spatially arrange multiple sources in a pseudorandom source array. The pseudorandom source array can replace the single source in analytical instruments relying on spatial separation of the sample or the probe particles/waves emitted by the sources. The large number of sources in this pseudorandom source array enhances the signal on a position sensitive detector. A mathematical deconvolution process retrieves a spectrum with improved signal-to-noise ratio from the detector signal.

Abstract: Novel methods and structures are disclosed herein which employ pseudorandom sequences to spatially arrange multiple sources in a pseudorandom source array. The pseudorandom source array can replace the single source in analytical instruments relying on spatial separation of the sample or the probe particles/waves emitted by the sources. The large number of sources in this pseudorandom source array enhances the signal on a position sensitive detector. A mathematical deconvolution process retrieves a spectrum with improved signal-to-noise ratio from the detector signal.