Abstract: In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the sulfur atom and nitrogen atom of the sulfonamide group include substituted or unsubstituted hydrocarbyl moieties, substituted or unsubstituted heterocycle moieties, polycyclic moieties, halogen, alkoxy, ether, ester, amide, sulfonyl, sulfonamidyl, sulfide, carbamate, and the like. Invention compounds are capable of a wide variety of uses. For example sulfonamide compounds can act to modulate production of amyloid ? protein and are useful in the prevention or treatment of a variety of diseases. Pharmaceutical compositions containing invention compounds are also provided. Such compositions have wide utility for the prevention or treatment of a variety of diseases.

Abstract: The invention includes a method for selecting sensors from a sensor network for tracking of at least one target having the steps of defining an individual of a genetic algorithm construct having n chromosomes, wherein each chromosome represents one sensor, defining a fitness function based on desired attributes of the tracking, selecting one or more of the individuals for inclusion in an initial population, executing a genetic algorithm on the initial population until defined convergence criteria are met, wherein execution of the genetic algorithm has the steps of choosing the fittest individual from the population, choosing random individuals from the population and creating offspring from the fittest and randomly chosen individuals.