Patents by Inventor Henry Joseph Horacek

Henry Joseph Horacek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Extended Release Formulation and Methods of Treating Adrenergic Dysregulation
    Publication number: 20110245314
    Abstract: A composition and method of treating adrenergic dysregulation by administering the composition is disclosed, wherein the composition comprises a ?2-adrenergic receptor agonist; a pharmaceutically acceptable hydrophilic matrix and a release-retardant of a metal alkyl sulfate. In embodiments, the composition provides a sustained release of the agonist, wherein after administration of the composition no more than once about every 12 hours to a subject having a steady state plasma concentration of the ?2-adrenergic receptor agonist, the agonist's plasma concentration peak-to-trough ratio is no greater than about 1.9.
    Type: Application
    Filed: April 8, 2011
    Publication date: October 6, 2011
    Inventors: Henry Joseph Horacek, Min Michael He, Moise A. Khayrallah
  • Extended release formulation and method of treating adrenergic dysregulation
    Patent number: 7884122
    Abstract: A composition and method of treating adrenergic dysregulation by administering the composition is disclosed, wherein the composition comprises a a2-adrenergic receptor agonist; a pharmaceutically acceptable hydrophilic matrix and a release-retardant of a metal alkyl sulfate. In embodiments, the composition provides a sustained release of the agonist, wherein after administration of the composition no more than once about every 12 hours to a subject having a steady state plasma concentration of the a2-adrenergic receptor agonist, the agonist's plasma concentration peak-to-trough ratio is no greater than about 1.9.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: February 8, 2011
    Assignee: Shionogi Pharma, Inc.
    Inventors: Henry Joseph Horacek, Min Michael He, Moise A. Khayrallah
  • Extended Release Formulation and Method of Treating Adrenergic Dysregulation
    Publication number: 20100209510
    Abstract: A composition and method of treating adrenergic dysregulation by administering the composition is disclosed, wherein the composition comprises a ?2-adrenergic receptor agonist; a pharmaceutically acceptable hydrophilic matrix and a release-retardant of a metal alkyl sulfate. In embodiments, the composition provides a sustained release of the agonist, wherein after administration of the composition no more than once about every 12 hours to a subject having a steady state plasma concentration of the ?2-adrenergic receptor agonist, the agonist's plasma concentration peak-to-trough ratio is no greater than about 1.9.
    Type: Application
    Filed: September 16, 2009
    Publication date: August 19, 2010
    Inventors: Henry Joseph Horacek, Min Michael He, Moise A. Khayrallah
  • Extended Release Formulation and Methods of Treating Adrenergic Dysregulation
    Publication number: 20100172991
    Abstract: A composition and method of treating adrenergic dysregulation by administering the composition is disclosed, wherein the composition comprises a ?2-adrenergic receptor agonist; a pharmaceutically acceptable hydrophilic matrix and a release-retardant of a metal alkyl sulfate. In embodiments, the composition provides a sustained release of the agonist, wherein after administration of the composition no more than once about every 12 hours (e.g., no more than once about every 24 hours) to a subject having a steady state plasma concentration of the ?2-adrenergic receptor agonist, the agonist's plasma concentration peak-to-trough ratio is no greater than about 1.9.
    Type: Application
    Filed: December 23, 2009
    Publication date: July 8, 2010
    Inventors: Henry Joseph Horacek, Min Michael He, Moise A. Khayrallah
  • EXTENDED RELEASE FORMULATION AND METHOD OF TREATING ADRENERGIC DYSREGULATION
    Publication number: 20100063123
    Abstract: A composition and method of treating adrenergic dysregulation by administering the composition is disclosed, wherein the composition comprises a a2-adrenergic receptor agonist; a pharmaceutically acceptable hydrophilic matrix and a release-retardant of a metal alkyl sulfate. In embodiments, the composition provides a sustained release of the agonist, wherein after administration of the composition no more than once about every 12 hours to a subject having a steady state plasma concentration of the a2-adrenergic receptor agonist, the agonist's plasma concentration peak-to-trough ratio is no greater than about 1.9.
    Type: Application
    Filed: November 10, 2009
    Publication date: March 11, 2010
    Inventors: Henry Joseph Horacek, Min Michael He, Moise A. Khayrallah
  • EXTENDED RELEASE FORMULATION AND METHOD OF TREATING ADRENERGIC DYSREGULATION
    Publication number: 20090087490
    Abstract: A composition and method of treating adrenergic dysregulation by administering the composition is disclosed, wherein the composition comprises a ?2-adrenergic receptor agonist; a pharmaceutically acceptable hydrophilic matrix and a release-retardant of a metal alkyl sulfate. In embodiments, the composition provides a sustained release of the agonist, wherein after administration of the composition no more than once about every 12 hours to a subject having a steady state plasma concentration of the ?2-adrenergic receptor agonist, the agonist's plasma concentration peak-to-trough ratio is no greater than about 1.9.
    Type: Application
    Filed: June 6, 2008
    Publication date: April 2, 2009
    Applicant: Addrenex Pharmaceuticals, Inc.
    Inventors: Henry Joseph Horacek, Min Michael He, Moise A. Khayrallah