Patents by Inventor Henry Joseph Niemczyk

Henry Joseph Niemczyk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pegylated amino acid derivatives and the process to synthesize the same
    Patent number: 8101729
    Abstract: The present invention is a series of novel pegylated amino acid derivatives containing branched polyethylene glycols, which are either the same or different molecular weights. Additionally, the N-pegylated lysine derivatives are enantiomerically pure. Also disclosed are oligopeptides such as Lysine-Lysine in which the free amino groups are protected as pegylated carbamates. 9-BBN complexes of lysine in which the epsilon nitrogen is functionalized as a pegylated carbamate and Bis pegylated derivatives of multifunctional heteroatom-containing amino acids such as cysteine, serine and glutamic acid are also disclosed. The present invention is also the process to prepare the novel pegylated amino acid derivatives for subsequent reaction with proteins. The process for synthesizing N-pegylated lysine derivatives in which the 9-borabicyclononane (9-BBN) complex of lysine is functionalized as a pegylated carbamate.
    Type: Grant
    Filed: March 19, 2007
    Date of Patent: January 24, 2012
    Inventors: Henry Joseph Niemczyk, Susan Dorothy Van Arnum
  • NOVEL PEGYLATED AMINO ACID DERIVATIVES AND THE PROCESS TO SYNTHESIZE THE SAME
    Publication number: 20080234497
    Abstract: The present invention is a series of novel pegylated amino acid derivatives containing branched polyethylene glycols, which are either the same or different molecular weights. Additionally, the N-pegylated lysine derivatives are enantiomerically pure. Also disclosed are oligopeptides such as Lysine-Lysine in which the free amino groups are protected as pegylated carbamates. 9-BBN complexes of lysine in which the epsilon nitrogen is functionalized as a pegylated carbamate and Bis pegylated derivatives of multifunctional heteroatom-containing amino acids such as cysteine, serine and glutamic acid are also disclosed. The present invention is also the process to prepare the novel pegylated amino acid derivatives for subsequent reaction with proteins. The process for synthesizing N-pegylated lysine derivatives in which the 9-borabicyclononane (9-BBN) complex of lysine is functionalized as a pegylated carbamate.
    Type: Application
    Filed: March 19, 2007
    Publication date: September 25, 2008
    Inventors: HENRY JOSEPH NIEMCZYK, Susan Dorothy Van Arnum
  • Ribonucleoside-TRIBOSE
    Patent number: 6518254
    Abstract: The present invention is a novel Ribonucleoside TRIBOSE. A process to prepare the nucleoside is also disclosed. The Ribonucleoside is a new chemical entity (NCE) not previously described. The preparation of the nucleoside portion of the molecule, also not previously described involves a thermal rearrangement of 3-Isoxazolecarboxylic acid, 5-methyl-,2-(phenylmethyl)-hydrazide, The resulting 1,2,3 ribonucleoside has anti-viral and anti-neoplastic activity potential.
    Type: Grant
    Filed: April 11, 2002
    Date of Patent: February 11, 2003
    Inventor: Henry Joseph Niemczyk