Abstract: A system for treating a wound, having a wound treatment device, a fluid input upstream side of the device, a fluid output downstream of the device; an air inlet valve upstream of the fluid output; an actuator to drive the air inlet valve between open and closed positions; a pump downstream of the fluid input; a motor to drive the pump to provide a negative pressure to the device; and a controller in configured to operate the air inlet valve and the pump. The controller is configured to (i) open the air inlet valve and operate the pump to maintain a first vacuum pressure at the wound treatment device and introduce air into the device, and (ii) close the air inlet valve and operate the pump to maintain a second vacuum pressure at the wound treatment device and remove air and fluid from the device.

Abstract: An acyclic tricarboxylic compound has been isolated from a culture of MF5453. The compound and its derivatives are active as squalene synthetase inhibitors and are useful in the treatment of hypercholesterolemia.

Abstract: A new Zaragozic acid analog has been isolated from a culture of MF5453. The compound and its derivatives are active as squalene synthetase inhibitors and are useful in the treatment of hypercholesterolemia.

Abstract: An antibiotic agent produced by the cultivation of Zalerion arboricola which is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity is described. Its production and isolation are also described.

Abstract: Compound of formulae (I) and (II) are HMG-CoA synthase inhibitors and exhibit antifungal activity.

Abstract: Compounds of formula (I) and (II): ##STR1## are HMG-CoA reductase inhibitors.

Abstract: Compounds of formula (I) and (II): ##STR1## are HMG-CoA reductase inhibitors.

Abstract: A high pressure liquid chromatography jacket includes a rectangular, fluid-tight enclosure which has a removable cover on which a pair of tubing seal fittings are mounted. The fittings form a fluid-tight seal around the inlet and discharge tubes of a chromatographic column which is mounted in the enclosure. The enclosure is connected to a source of temperature controlled fluid which circulates through the enclosure and controls the temperature of the chromatographic column.In an alternative embodiment of the invention, a valve is provided which allows sample materials being loaded to enter a sample storage loop, which is exposed to the temperature controlled fluid. The sample, whose temperature has been controlled by the temperature controlled fluid, is then injected into a chromatographic column under high pressure.

Abstract: 6-Hydroxy-2-(2-hydroxy-4-methoxyphenyl)benzofuran derivatives and related pharmaceutical compositions and methods of treatment are disclosed. The compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, they are useful therapuetic agents for treating allergic conditions, asthma, cardiovascular disorders and inflammation.

Abstract: Medicarpin derivatives and related pharmaceutical compositions and methods of treatment are disclosed. The compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, they are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders and inflammation.

Abstract: An all-TEFLON filter-degasser for removing solids and gases from a solvent. The filter-degasser has a filtering portion, a vacuum application portion downstream of the filtering portion, and a solvent bottle connecting portion. The vacuum application portion includes an externally tapered male member, and the solvent bottle connecting portion includes an internally identically tapered female member. The male member can be inserted into and withdrawn from the female member without requiring any relative rotation therebetween, so that the filter-degasser can be connected hermetically airtight to the solvent bottle likewise without any rotation being required therebetween. This abstract is not to be taken either as a complete exposition or as a limitation of the present invention, however, the full nature and extent of the invention being discernible only by reference to and from the entire disclosure.

Abstract: Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise compounds which have structures: ##STR1## Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.

Abstract: 4-Amino- and 2,4-diaminopyrimidines with a quaternized ring nitrogen and an oxygen bearing substituent such as hydroxyalkyl, alkoxyalkyl, or alkanoyl on one of the exo- or endocyclic nitrogens and a C.sub.6-18 alkyl on another, are highly active antimicrobial agents with a relatively low acute mammalian toxicity.

Abstract: Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise compounds which have structures: ##STR1## Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.