Abstract: The method and system of the invention provide especially for continuously obtaining and analyzing, on a real time basis, sweat from a selected area of skin on the body of a person, especially a neonate, being diagnosed for cystic fibrosis, by causing sweating of the selected area of skin, by placing an electrically positive iontophoretic electrode device of a set of said devices over the selected area of skin preferably within a previously placed receiving and holding device which, following the induction of sweat and removal of the electrically positive iontophoretic electrode device, receives a sweat-sensing electrode device that continuously sends electrical signals to sweat analysis circuitry for providing a digital readout of the ionic composition of the sweat. The receiving and holding device insures recovery and utilization of essentially all of the sweat being produced by the selected area of skin.

Abstract: A sweat-collection device formed as a solid body having a shallowly concave, sweat-collecting surface at a face thereof defining a concavity with a rim lying wholly within a common plane for firm placement over an iontophoresis-stimulated area of a person's skin to collect sweat from the skin area and pass it through a bore at the center of the concavity. The concavity is so shallow that no dead space occurs between the collecting surface and the skin and flesh bulged into the concavity when the device is applied to a patient whose sweat is to be collected for testing. Optionally, the concavity may be modified without introducing dead space thereinto, to incorporate barrier means for preventing unusually soft skin and flesh of infants and some adults from bulging into and closing the bore.

Abstract: An iontophoretic electrode device, method, and hydrophilic, hydrated gel insert for the electrode device all involve a preformed, shape-retaining, gel body preferably of disc formation having mutually opposite, parallel faces. An agar gel disc having an ionic drug diffused throughout is the preferred, iontophoretic gel body that is packaged and sold as such for insertion in a cup-like receptacle and securement to an electrode plate within the receptacle, so as to protrude free and clear therefrom for pressing against the skin of a medical patient.