Abstract: The disclosure provides methods and compositions, e.g., kits and microarray, for assessing the immune response in a murine tumor model based on the expression of a gene panel that characterizes tumor immune interactions.

Abstract: A die including a die body having a first body surface, a second body surface on an opposite side of the die body as the first body surface, an interconnect region adjacent to the first body surface including interconnect dielectric layers with metal lines and vias, a transistor region above the interconnect region, the metal lines and vias making electrical connections to one or more power rails of the transistor region and electrically connected to transistors of the transistor region, a power region above the transistor region including an electro-conductive film on the second body surface and TSVs in the power region, an outer end of the TSV contacting the film and an embedded end of the TSVs contacting one of the power rails. A method of manufacturing an IC package and computer with the IC package are also disclosed.

Abstract: A clean example to be learned is sampled, the clean example being from an input set of training data to be used to train the generative model. Initial values are computed using the sampled clean example and the generative model. The initial values from the clean example and the computed initial values are fed to a Reversible-Heun (RH) Stochastic Differential Equation (SDE) solver to forward propagate using Schrodinger Bridge Forward-Backward Stochastic Differential Equations (SB-FBSDEs) computed for the generative model, producing predicted output values. A loss function is computed to compare the initial values and the predicted output values. A reverse of the reversible Heun SDE solver is used for, solving the stochastic adjoint SDE to compute the gradient and update the weights of the generative model.

Abstract: A die including a die body having a first body surface, a second body surface on an opposite side of the die body as the first body surface, an interconnect region adjacent to the first body surface including interconnect dielectric layers with metal lines and vias, a transistor region above the interconnect region, the metal lines and vias making electrical connections to one or more power rails of the transistor region and electrically connected to transistors of the transistor region, a power region above the transistor region including an electro-conductive film on the second body surface and TSVs in the power region, an outer end of the TSV contacting the film and an embedded end of the TSVs contacting one of the power rails. A method of manufacturing an IC package and computer with the IC package are also disclosed.

Abstract: The disclosure provides methods and compositions, e.g., kits, for identifying or authenticating a sample, e.g., a tumor model, based on the genotype of the sample at a group of SNP loci.

Abstract: The disclosure provides methods and compositions, e.g., kits and microarray, for assessing the immune response in a murine tumor model based on the expression of a gene panel that characterizes tumor immune interactions.

Abstract: The disclosure provides methods and compositions, e.g., kits, for identifying or authenticating a sample, e.g., a tumor model, based on the genotype of the sample at a group of SNP loci.

Abstract: The present disclosure provides methods of detecting a fusion gene of HNF4G and RSPO2 in a nucleic acid-containing sample, and a primer set, a probe set and a kit for detecting the fusion gene are also provided. Animal models for a human disease positive for the fusion gene are also provided herein. In addition, the present disclosure relates to the methods for assessing and identifying an agent effective on the fusion gene of HNF4G and RSPO2 or a human disease positive for a fusion gene of HNF4G and RSPO2 and thereby treating said disease are also provided.

Abstract: The present disclosure provides methods of detecting a fusion gene of HNF4G and RSPO2 in a nucleic acid-containing sample, and a primer set, a probe set and a kit for detecting the fusion gene are also provided. Animal models for a human disease positive for the fusion gene are also provided herein. In addition, the present disclosure relates to the methods for assessing and identifying an agent effective on the fusion gene of HNF4G and RSPO2 or a human disease positive for a fusion gene of HNF4G and RSPO2 and thereby treating said disease are also provided.

Abstract: A system and method for virally growing a social network. The social network system receives a member account sign-up message for a first social network from a first member. The social network system then posts a member sign-up notification to the first member's event wall on a second social network; wherein the first member has one or more social contacts through the second social network. For at least a second respective member in the one or more social contacts, the social network system posts a personalized invitation message as a comment to the member sign-up notification on the first member's event wall, wherein the comment is initially hidden from all members other than the second respective member of the one or more member contacts.

Abstract: A system and method for virally growing a social network. The social network system receives a member account sign-up message for a first social network from a first member. The social network system then posts a member sign-up notification to the first member's event wall on a second social network; wherein the first member has one or more social contacts through the second social network. For at least a second respective member in the one or more social contacts, the social network system posts a personalized invitation message as a comment to the member sign-up notification on the first member's event wall, wherein the comment is initially hidden from all members other than the second respective member of the one or more member contacts.

Abstract: The present teachings relate to methods of screening for a therapeutic agent for human acute myelogenous leukemia (AML) and methods for treating AML. The method includes administering a test substance to an immunocompromised NOD/SCID mouse engrafted with a substance containing a leukemic cell derived from a human AML patient and a step of assessing improvement in leukemia in the mouse and/or to monitor a side effect of the test substance. The method can further include monitoring a side effect of the test substance in the mouse.

Abstract: The present teachings relate to methods of screening for a therapeutic agent, selecting a treatment and monitoring a treatment for a human disease or infection and methods for producing a mouse model for human disease or infection wherein the mouse has a functioning human immune system. The method includes administering a test substance to an immunocompromised NOD/SCID mouse with a reconstituted human immune system and is also engrafted with a substance containing a diseased or infectious cell derived from a human diseased or infected patient and a step of assessing improvement in the disease or infection of the mouse and/or to monitor a side effect of the test substance.

Abstract: Methods and systems for processing Ethernet data are disclosed and may comprise receiving Ethernet data via a single gigabit Ethernet IP telephone chip. A secure application key may be received from a secure server by an OSM integrated within the gigabit Ethernet IP telephone chip for processing the received Ethernet data. The received Ethernet data may be processed by the gigabit Ethernet IP telephone chip based on the received secure application key. A unique security identifier internal to the single gigabit Ethernet IP telephone chip may be communicated off-chip to the secure server. The unique security identifier may identify the single gigabit Ethernet IP telephone chip. The secure server may authenticate the gigabit Ethernet IP telephone chip based on the unique security identifier internal to the single gigabit Ethernet IP telephone chip, prior to the receiving of the secure application key.

Abstract: Methods and systems for an Ethernet IP phone chip are provided. In this regard, data may be received via a first port of an Ethernet switch in the Ethernet IP phone chip, and the port(s) via which the data is forwarded may be determined based on characteristics of the data. The Ethernet switch may receive data from a network via a first port, and communicate the received data to one or more on-chip interfaces via a second port. The on-chip interfaces may process the received data and may communicate video contained in the data to an off-chip video processing device. The Ethernet IP phone chip may receive video data from an off-chip video processing device via one or more on-chip interfaces, packetize the video data into one or more Ethernet packets; and communicate the packet(s) onto a network link via the Ethernet switch.

Abstract: Techniques for interactively presenting word-alignments of multilingual translations and automatically improving those translations based upon user feedback are described herein. With one or more implementations of the techniques described herein, a word-alignment user-interface (UI) concurrently displays a pair of bilingual sentences, where one is a translation of the other, and interactively highlights linked (i.e., “word-aligned”) words and phrases of the pair. Other implementations of the techniques described herein offer an option for a user to provide feedback about the existing word-alignments or realign the words or phrases. In still other described implementations, word-alignment is automatically improved based upon that user feedback.

Abstract: Methods and systems for processing Ethernet data are disclosed and may comprise receiving Ethernet data via a single gigabit Ethernet IP telephone chip. A secure application key may be received from a secure server by an OSM integrated within the gigabit Ethernet IP telephone chip for processing the received Ethernet data. The received Ethernet data may be processed by the gigabit Ethernet IP telephone chip based on the received secure application key. A unique security identifier internal to the single gigabit Ethernet IP telephone chip may be communicated off-chip to the secure server. The unique security identifier may identify the single gigabit Ethernet IP telephone chip. The secure server may authenticate the gigabit Ethernet IP telephone chip based on the unique security identifier internal to the single gigabit Ethernet IP telephone chip, prior to the receiving of the secure application key.

Abstract: Methods and systems for an Ethernet IP phone chip are provided. In this regard, data may be received via a first port of an Ethernet switch in the Ethernet IP phone chip, and the port(s) via which the data is forwarded may be determined based on characteristics of the data. The Ethernet switch may receive data from a network via a first port, and communicate the received data to one or more on-chip interfaces via a second port. The on-chip interfaces may process the received data and may communicate video contained in the data to an off-chip video processing device. The Ethernet IP phone chip may receive video data from an off-chip video processing device via one or more on-chip interfaces, packetize the video data into one or more Ethernet packets; and communicate the packet(s) onto a network link via the Ethernet switch.

Abstract: A voice queue includes a primary queue and a secondary queue. The secondary queue is operable to store voice packets and generate timestamps for the voice packets. The primary queue is operable to receive the voice packets from the secondary queue, store the timestamps for the voice packets, and store sequence numbers for the voice packets.

Abstract: Methods and systems for an Ethernet IP phone chip are provided. In this regard, data may be received via a first port of an Ethernet switch in the Ethernet IP phone chip, and the port(s) via which the data is forwarded may be determined based on characteristics of the data. The Ethernet switch may receive data from a network via a first port, and communicate the received data to one or more on-chip interfaces via a second port. The on-chip interfaces may process the received data and may communicate video contained in the data to an off-chip video processing device. The Ethernet IP phone chip may receive video data from an off-chip video processing device via one or more on-chip interfaces, packetize the video data into one or more Ethernet packets; and communicate the packet(s) onto a network link via the Ethernet switch.