Patents by Inventor Henry Lu

Henry Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections
    Patent number: 7410979
    Abstract: The present invention relates to anti-HCV dihaloacetamide compounds in synergistic combination with an interferon and/or ribavirin and pharmaceutical compositions thereof for inhibition of the replication of HCV virus. The present invention also relates to the use of the compositions to inhibit HCV replication and/or proliferation and to treat or prevent HCV infections.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: August 12, 2008
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventor: Henry Lu
  • Pyridyl Substituted Heterocycles Useful For Treating Or Preventing HCV Infection
    Publication number: 20070155966
    Abstract: The present invention relates to pyridyl substituted heterocycles and hydro isomers thereof and pharmaceutical compositions thereof that inhibit replication and/or proliferation of HCV virus.
    Type: Application
    Filed: November 21, 2006
    Publication date: July 5, 2007
    Applicant: RIGEL PHARMACEUTICALS, INC.
    Inventors: Rajinder Singh, Dane Goff, John Partridge, Henry Lu
  • HCV Inhibitors And Methods Of Using Them
    Publication number: 20070149520
    Abstract: The present invention comprises tetrazoloquinoline-compounds that are inhibitors of HCV. Compositions comprising the compounds in combination with a pharmaceutically acceptable carrier are also disclosed, as are methods of using the compounds and compositions to inhibit HCV infection of a cell, particular in the form of treating HCV infection in a mammal.
    Type: Application
    Filed: December 7, 2006
    Publication date: June 28, 2007
    Applicant: RIGEL PHARMACEUTICALS, INC.
    Inventors: Sambaiah Thota, Ankush Argade, Rajinder Singh, Henry Lu, Peiyong Huang
  • Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof
    Publication number: 20070004723
    Abstract: The present invention relates to substituted diphenyl heterocycle compounds having an oxadiazole moiety and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication and/or proliferation and to treat or prevent HCV infections.
    Type: Application
    Filed: February 22, 2005
    Publication date: January 4, 2007
    Inventors: Dane Goff, Rajinder Singh, Henry Lu
  • Substituted diphenyl heterocycles useful for treating HCV infection
    Patent number: 7153880
    Abstract: The present invention relates to substituted diphenyl heterocycle compounds and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication and/or proliferation and to treat or prevent HCV infections.
    Type: Grant
    Filed: June 22, 2004
    Date of Patent: December 26, 2006
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Dane Goff, Henry Lu, Sarkiz D. Issakani, Thomas Sun
  • Heterocyclic Anti-Viral Compounds Comprising Metabolizable Moieties And Their Uses
    Publication number: 20060247287
    Abstract: The present invention relates to prodrugs and compositions thereof useful for treating or preventing Hepatitis C virus (HCV) infections. In particular, the present invention relates to prodrugs of substituted diphenyl-, diheteroaryl- and mixed phenyl heteroaryl substituted five-membered heterocycle compounds, compositions comprising the compounds and the use of such compounds and compositions to inhibit HCV replication and/or proliferation as a therapeutic approach towards the treatment and/or prevention of HCV infections in humans and animals.
    Type: Application
    Filed: May 2, 2006
    Publication date: November 2, 2006
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Dane Goff, Ihab Darwish, Rao Kolluri, Henry Lu, Gary Park
  • Benzisothiazoles useful for treating or preventing HCV infection
    Publication number: 20060229294
    Abstract: The present invention relates to benzisothiazoles and pharmaceutical compositions thereof that inhibit replication and/or proliferation of HCV virus. The present invention also relates to the use of the benzisothiazoles and pharmaceutical compositions comprising the compounds to treat or prevent HCV infections.
    Type: Application
    Filed: February 24, 2006
    Publication date: October 12, 2006
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Hui Hong, Eileen Goldstein, Emily Stauffer, Dane Goff, Rao Kolluri, Ihab Darwish, Rajinder Singh, Henry Lu
  • Heterotricylic compounds for use as HCV inhibitors
    Publication number: 20050282850
    Abstract: The present invention comprises tetrazoloquinoline-compounds that are inhibitors of HCV. Compositions comprising the compounds in combination with a pharmaceutically acceptable carrier are also disclosed, as are methods of using the compounds and compositions to inhibit HCV infection of a cell, particular in the form of treating HCV infection in a mammal.
    Type: Application
    Filed: June 3, 2005
    Publication date: December 22, 2005
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Sambaiah Thota, Rajinder Singh, Guy Laidig, Henry Lu
  • Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses
    Publication number: 20050239751
    Abstract: The present invention relates to substituted prodrug and compositions thereof useful for treating or preventing Hepatitis C virus (HCV) infections. In particular, the present invention relates to prodrugs of substituted diphenyl-, diheteroaryl- and mixed phenyl heteroaryl substituted five-membered heterocycle compounds, compositions comprising the compounds and the use of such compounds and compositions to inhibit HCV replication and/or proliferation as a therapeutic approach towards the treatment and/or prevention of HCV infections in humans and animals.
    Type: Application
    Filed: March 25, 2005
    Publication date: October 27, 2005
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Dane Goff, Rao Kolluri, Ihab Darwish, John Partridge, Robin Cooper, Henry Lu, Gary Park
  • Substituted indoles and their use as hcv inhibitors
    Publication number: 20050215614
    Abstract: The present invention comprises indole-derivatives that are inhibitors of HCV. Composition comprising the compounds in combination with a pharmaceutically acceptable carrier are also disclosed, as are methods of using the compounds and compositions to inhibit HCV infection of a cell, particular in the form of treating HCV infection in a mammal.
    Type: Application
    Filed: October 15, 2003
    Publication date: September 29, 2005
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Ihab Darwish, Rao Kolluri, Sambaiah Thota, Henry Lu
  • Methods and compositions for the identification of anti-poxvirus agents
    Publication number: 20050180994
    Abstract: The invention provides methods for identifying an anti-poxviral agents. In many embodiments, the methods involve contacting a poxviral p28 polypeptide with a candidate agent, and determining an effect of the agent on a ubiquitin ligase activity of the p28 polypeptide. The effect of the agent may be determined using a variety of different cell based or biochemical assays, such as polyubiquitylation assays and cell viability assays. The invention also provides methods for modulating poxvirus pathogenicity in a cell, and methods of treating an individual infected with a poxvirus. The subject methods find use in a variety of drug discovery, research and military applications.
    Type: Application
    Filed: October 27, 2004
    Publication date: August 18, 2005
    Inventors: Henry Lu, Jianing Huang, Donald Payan
  • Methods for identifying polypeptide factors interacting with RNA
    Patent number: 6927031
    Abstract: The present invention relates to methods of screening for target polypeptides that bind to RNA, using affinity purification methods, and the use of such target polypeptide for drug discovery and in methods of treating and preventing disease, e.g., HCV infection.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: August 9, 2005
    Assignee: Rigel Pharmaceuticals, Incorporated
    Inventors: Henry Lu, Weiqun Li, David Anderson
  • Substituted heterocycles useful for treating HCV infection
    Publication number: 20050143433
    Abstract: The present invention relates to substituted heterocyclic compounds, such as isoxazoloanthrones, and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication and/or proliferation and to treat or prevent HCV infections.
    Type: Application
    Filed: November 23, 2004
    Publication date: June 30, 2005
    Inventors: Rajinder Singh, Henry Lu
  • Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections
    Publication number: 20050129659
    Abstract: The present invention relates to anti-HCV dihaloacetamide compounds in synergistic combination with an interferon and/or ribavirin and pharmaceutical compositions thereof for inhibition of the replication of HCV virus. The present invention also relates to the use of the compositions to inhibit HCV replication and/or proliferation and to treat or prevent HCV infections.
    Type: Application
    Filed: November 19, 2004
    Publication date: June 16, 2005
    Inventor: Henry Lu
  • HCV inhibitors and methods of using them
    Publication number: 20050090521
    Abstract: The present invention comprises tetrazoloquinoline-compounds that are inhibitors of HCV. Compositions comprising the compounds in combination with a pharmaceutically acceptable carrier are also disclosed, as are methods of using the compounds and compositions to inhibit HCV infection of a cell, particular in the form of treating HCV infection in a mammal.
    Type: Application
    Filed: September 27, 2004
    Publication date: April 28, 2005
    Inventors: Sambaiah Thota, Ankush Argade, Rajinder Singh, Henry Lu, Peiyong Huang
  • Methods of identifying HCV NS5B polymerase inhibitors and their uses
    Publication number: 20050009877
    Abstract: The present invention relates to a variety of screening methods, utilizing both biochemical and cellular assays as well as in silicon assays, for use in the discovery of agents active in the treating or preventing Hepatitis C virus (HCV) infections. The invention also relates to methods of inhibiting an HCV NS5B polymerase and to the treatment and/or prevention of HCV infections with compounds having specified binding properties.
    Type: Application
    Filed: May 17, 2004
    Publication date: January 13, 2005
    Inventor: Henry Lu
  • Substituted diphenyl heterocycles useful for treating HCV infection
    Publication number: 20040236112
    Abstract: The present invention relates to substituted diphenyl heterocycle compounds and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication and/or proliferation and to treat or prevent HCV infections.
    Type: Application
    Filed: June 22, 2004
    Publication date: November 25, 2004
    Inventors: Rajinder Singh, Dane Goff, Henry Lu, Sarkiz D. Issakani, Thomas Sun
  • Substituted diphenyl heterocycles useful for treating HCV infection
    Patent number: 6759538
    Abstract: The present invention relates to substituted diphenyl heterocycle compounds and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication and/or proliferation and to treat or prevent HCV infections.
    Type: Grant
    Filed: November 1, 2002
    Date of Patent: July 6, 2004
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Dane Goff, Henry Lu, Sarkiz D. Issankani, Thomas Sun
  • Methods for identifying polypeptide factors interacting with RNA
    Publication number: 20030194712
    Abstract: The present invention relates to methods of screening for target polypeptides that bind to RNA, using affinity purification methods, and the use of such target polypeptide for drug discovery and in methods of treating and preventing disease, e.g., HCV infection.
    Type: Application
    Filed: April 12, 2002
    Publication date: October 16, 2003
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Henry Lu, Weiqun Li, David Anderson
  • Substituted diphenyl heterocycles useful for treating HCV infection
    Publication number: 20030165561
    Abstract: The present invention relates to substituted diphenyl heterocycle compounds and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication and/or proliferation and to treat or prevent HCV infections.
    Type: Application
    Filed: November 1, 2002
    Publication date: September 4, 2003
    Inventors: Rajinder Singh, Dane Goff, Henry Lu, Sarkiz D. Issakani, Thomas Sun