Patents by Inventor Henry M. Holava

Henry M. Holava has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microsomal triglyceride transfer protein
    Publication number: 20030166590
    Abstract: Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.
    Type: Application
    Filed: August 21, 2001
    Publication date: September 4, 2003
    Inventors: John R. Wetterau, Daru Young Sharp, Richard E. Gregg, Scott A. Biller, John K. Dickson, R. Michael Lawrence, John E. Lawson, Henry M. Holava, Richard A. Partyka
  • Inhibitors of microsomal triglyceride transfer protein and method
    Patent number: 6066650
    Abstract: Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein R.sup.1 to R.sup.7, Q, X and Y are as defined herein.
    Type: Grant
    Filed: July 21, 1997
    Date of Patent: May 23, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Scott A. Biller, John K. Dickson, R. Michael Lawrence, David R. Magnin, Michael A. Poss, Richard B. Sulsky, Joseph A. Tino, John E. Lawson, Henry M. Holava, Richard A. Partyka
  • Inhibitors of microsomal triglyceride transfer protein and method
    Patent number: 6034098
    Abstract: Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein R.sup.1 to R.sup.7, Q, X and Y are as defined herein.
    Type: Grant
    Filed: July 21, 1997
    Date of Patent: March 7, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Scott A. Biller, John K. Dickson, R. Michael Lawrence, David R. Magnin, Michael A. Poss, Richard B. Sulsky, Joseph A. Tino, John E. Lawson, Henry M. Holava, Richard A. Partyka
  • Inhibitors of microsomal triglyceride transfer protein and method
    Patent number: 5883099
    Abstract: Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein R.sup.1 to R.sup.7, Q, X and Y are as defined herein.
    Type: Grant
    Filed: July 21, 1997
    Date of Patent: March 16, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: Scott A. Biller, John K. Dickson, R. Michael Lawrence, David R. Magnin, Michael A. Poss, Richard B. Sulsky, Joseph A. Tino, John E. Lawson, Henry M. Holava, Richard A. Partyka
  • Nucleic acids encoding microsomal trigyceride transfer protein
    Patent number: 5595872
    Abstract: Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.
    Type: Grant
    Filed: September 3, 1993
    Date of Patent: January 21, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: John R. Wetterau, II, Daru Y. Sharp, Richard E. Gregg, Scott A. Biller, John K. Dickson, R. Michael Lawrence, John E. Lawson, Henry M. Holava, Richard A. Partyka