Patents by Inventor Henry Masur

Henry Masur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification of a region of the major surface glycoprotein (MSG) gene of human Pneumocystis carinii
    Publication number: 20040043409
    Abstract: Particularly sensitive techniques for the detection of P. carinii in clinical samples are disclosed. These techniques relate to the PCR amplification and/or detection of human-P. carinii major surface glycoprotein (MSG) gene sequences. Also disclosed are seven novel genes encoding human-P. carinii MSG, and the proteins encoded for by these genes. These genes provide proof that human-P. carinii MSG is encoded for by a highly conserved gene family, and that the corresponding proteins have a very highly conserved region of about 100 amino acids near their C-terminal end. This highly conserved carboxy-terminal region has a significantly different sequence than that found in rat-derived MSG.
    Type: Application
    Filed: September 2, 2003
    Publication date: March 4, 2004
    Applicant: The Government of the USA represented by Secretary of the Department of Health & Human Services
    Inventors: Joseph A. Kovacs, Shengning Huang, Henry Masur, Steven H. Fischer, Vee J. Gill, Qin Mei
  • Identification of a region of the major surface glycoprotein (MSG) gene of human Pneumocystis carinii
    Patent number: 6664053
    Abstract: Particularly sensitive techniques for the detection of P. carinii in clinical samples are disclosed. These techniques relate to the PCR amplification and/or detection of human-P. carinii major surface glycoprotein (MSG) gene sequences. Also disclosed are seven novel genes encoding human-P. carinii MSG, and the proteins encoded for by these genes. These genes provide proof that human-P. carinii MSG is encoded for by a highly conserved gene family, and that the conesponding proteins have a very highly conserved region of about 100 amino acids near their C-terminal end. This highly conserved carboxy-terminal region has a significantly different sequence than that found in rat-derived MSG.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: December 16, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Joseph A. Kovacs, Shengning Huang, Henry Masur, Steven H. Fischer, Vee J. Gill, Qin Mei
  • Kit for diagnosis of P. carninii and method thereof
    Patent number: 5246833
    Abstract: Hybridomas producing antibodies having specific binding affinity against Pneumocystis carinii have been obtained and a method and kit for detecting P. carinii infection in humans have been described.
    Type: Grant
    Filed: May 4, 1990
    Date of Patent: September 21, 1993
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Joseph A. Kovacs, Henry Masur
  • Treatment of a microbial infection with drugs containing para-acetamidobenzoic acid
    Patent number: 5068253
    Abstract: The present invention relates to a method of treating or preventing a microbial infection, such as Pneumocystis carinii or Toxoplasma gondii, in a patient comprising administering to the patient an antimicrobially effective amount of p-acetamidobenzoic acid or a pharmaceutically acceptable salt thereof so that the microbial infection is inhibited. P-acetamidobenzoic acid or an acceptable salt thereof can be used to treat infections caused by Pneumocystis carinii, Toxoplasma gondii, Plasmodium species and other microorganisms containing the enzyme dihydropteroate synthetase such as most bacteria and some yeasts. The method of the present invention is particularly applicable in situations where the patient is immunosuppressed.
    Type: Grant
    Filed: July 11, 1990
    Date of Patent: November 26, 1991
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Joseph Kovacs, Henry Masur, Carmen Allegra
  • Monoclonal antibody against human pneumocystis carinii
    Patent number: 4925800
    Abstract: Hybridomas producing antibodies having specific binding affinity against Pneumocystis carinii having been obtained and a method and kit for detecting P. carinii infection in humans having been described.
    Type: Grant
    Filed: December 4, 1986
    Date of Patent: May 15, 1990
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Joseph A. Kovacs, Henry Masur
  • Use of trimetrexate as antiparasitic agent
    Patent number: 4694007
    Abstract: A method of treating infections of Toxoplasmosis or P. carini comprising administering to the host an effective amount of trimetrexate, (2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline.
    Type: Grant
    Filed: May 20, 1986
    Date of Patent: September 15, 1987
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Carmen Allegra, James C. Drake, Bruce A. Chabner, Henry Masur, Joseph A. Kovacs