Patents by Inventor Henry McSorley

Henry McSorley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Materials and methods for inducing regulatory T cells
    Patent number: 11866467
    Abstract: The present invention concerns a structurally distinct immunosuppressive mimic of TGF-? that is a potent inducer of murine and human regulatory T cells and provides a therapeutic agent for the treatment of inflammatory disorders. Disclosed herein is a novel parasite TGF-? mimic which fully replicates the biological and functional properties of TGF-?, including binding to mammalian TGF-? receptors and inducing Foxp3+ Treg in both murine and human CD4+ T cells. This TGF-? mimic shares no homology to mammalian TGF-? or other members of the TGF-? family, but s distinctly related to the component control protein (CCP) superfamily.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: January 9, 2024
    Assignees: THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW, THE UNIVERSITY OF EDINBURGH
    Inventors: Richard Maizels, Danielle Smyth, Henry McSorley
  • MATERIALS AND METHODS FOR INDUCING REGULATORY T CELLS
    Publication number: 20210355176
    Abstract: The present invention concerns a structurally distinct immunosuppressive mimic of TGF-? that is a potent inducer of murine and human regulatory T cells and provides a therapeutic agent for the treatment of inflammatory disorders. Disclosed herein is a novel parasite TGF-? mimic which fully replicates the biological and functional properties of TGF-?, including binding to mammalian TGF-? receptors and inducing Foxp3+ Treg in both murine and human CD4+ T cells. This TGF-? mimic shares no homology to mammalian TGF-? or other members of the TGF-? family, but s distinctly related to the component control protein (CCP) superfamily.
    Type: Application
    Filed: August 3, 2018
    Publication date: November 18, 2021
    Inventors: Richard Maizels, Danielle Smyth, Henry McSorley