Abstract: The present application describes stapled peptide degron chimeras, which act as protein degradation inducing moieties, either by combining a stapled peptide that binds a disease-related protein with a small molecule degron, such as a cereblon- or VHL-binding small molecule as the degron, or a polypeptide sequence degron, such as a Cop1-binding Trib peptide as the degron; or by combining a stapled peptide degron with a peptide, such as a stapled peptide, or a small molecule that binds a disease-related protein. The present application also relates to methods for the targeted degradation of endogenous proteins through the use of stapled peptide degron chimeras which can be utilized in the treatment of proliferative disorders or other conditions whereby elimination of a disease-causing or disease-related protein would have a therapeutic benefit. The present application also provides methods for making compounds of the application and intermediates thereof.

Abstract: During source code compilation to a first processor instruction set architecture (ISA), a compiler encounters a memory ordering constraint specified in the source code. The compiler generates binary emulation metadata that is usable during emulation of emitted machine code instructions of the first ISA, in order to enforce the memory ordering constraint within corresponding machine code instructions of a second ISA. An emulator utilizes this binary emulation metadata during emulation of a resulting executable image at a processor implementing the second ISA. When the emulator encounters a machine code instruction in the image that performs a memory operation, it identifies an instruction memory address corresponding to the instruction. The emulator determines whether the binary emulation metadata identifies the instruction memory address as being associated with a memory ordering constraint.

Abstract: During source code compilation to a first processor instruction set architecture (ISA), a compiler encounters a memory ordering constraint specified in the source code. The compiler generates binary emulation metadata that is usable during emulation of emitted machine code instructions of the first ISA, in order to enforce the memory ordering constraint within corresponding machine code instructions of a second ISA. An emulator utilizes this binary emulation metadata during emulation of a resulting executable image at a processor implementing the second ISA. When the emulator encounters a machine code instruction in the image that performs a memory operation, it identifies an instruction memory address corresponding to the instruction. The emulator determines whether the binary emulation metadata identifies the instruction memory address as being associated with a memory ordering constraint.

Abstract: During source code compilation to a first processor instruction set architecture (ISA), a compiler encounters a memory ordering constraint specified in the source code. The compiler generates binary emulation metadata that is usable during emulation of emitted machine code instructions of the first ISA, in order to enforce the memory ordering constraint within corresponding machine code instructions of a second ISA. An emulator utilizes this binary emulation metadata during emulation of a resulting executable image at a processor implementing the second ISA. When the emulator encounters a machine code instruction in the image that performs a memory operation, it identifies an instruction memory address corresponding to the instruction. The emulator determines whether the binary emulation metadata identifies the instruction memory address as being associated with a memory ordering constraint.

Abstract: During source code compilation to a first processor instruction set architecture (ISA), a compiler encounters a memory ordering constraint specified in the source code. The compiler generates binary emulation metadata that is usable during emulation of emitted machine code instructions of the first ISA, in order to enforce the memory ordering constraint within corresponding machine code instructions of a second ISA. An emulator utilizes this binary emulation metadata during emulation of a resulting executable image at a processor implementing the second ISA. When the emulator encounters a machine code instruction in the image that performs a memory operation, it identifies an instruction memory address corresponding to the instruction. The emulator determines whether the binary emulation metadata identifies the instruction memory address as being associated with a memory ordering constraint.

Abstract: A system for determining position, velocity, time, and/or altitude of a vehicle of object using GNSS under a broad range of dynamic conditions. The system may utilize a plurality of antennas in some aspects. In some aspects, the system may operate in a differential mode incorporating a fixed or mobile base station. In some aspects, the system may be connected to a smart phone, tablet, or other mobile computing device.

Abstract: A tethered airborne electrical power generation system which may utilize a strutted frame structure with airfoils built into the frame to keep wind turbine driven generators which are within the structure airborne. The primary rotors utilize the prevailing wind to generate rotational velocity. Electrical power generated is returned to ground using a tether that is also adapted to fasten the flying system to the ground. The flying system is adapted to be able to use electrical energy to provide power to the primary turbines which are used as motors to raise the system from the ground, or mounting support, into the air. The system may then be raised into a prevailing wind and use airfoils in the system to provide lift while the system is tethered to the ground. The motors may then resume operation as turbines for electrical power generation. The system may be somewhat planar in that many turbines may have their rotors substantially in one or more planes or planar regions.

Abstract: Accomplishments among players in a gaming environment are compared. A data store that stores a plurality of user profiles which comprise information gathered from users playing one or more video games on a game console. Various accomplishments and achievements attained by the players are associated with the user profile and includes achievement stamps for unlocking various achievements in particular games. At least two user profiles may be selected from the data store to extract information related to accomplishments and achievements the selected players. The selected information may then be displayed simultaneously to facilitate comparison of the players accomplishments.

Abstract: Mechanisms are disclosed for visual identification of a user in a gaming environment. For example, a digital image is used to identify a user, whether the user is on-line or off-line. This digital image is easily verifiable as an appropriate and non-offensive image because it may come form a controlled digital image source (or set of sources). The digital image is also revocable in a variety of gaming environment contexts by a gaming authority. Lastly, the digital image is changeable depending on the context of the gaming environment, in one aspect, being configured to be visible to the entire gaming environment in one form, and being visible to a subset of the gaming environment in another form.

Abstract: An anti-icing assembly for an airfoil such as an aircraft wing or slat comprises: (a) an airfoil having an exterior surface and interior wall defining an interior cavity, and bottom, middle and side portions all adjacent to the interior cavity; (b) an inlet plenum integral to the airfoil, wherein the inlet plenum comprises (i) an inlet baffle capable of directing hot gases into the airfoil interior cavity and (ii) a throat section interfacing the inlet plenum and airfoil interior cavity; and (c) an outlet plenum integral to the airfoil, wherein the outlet plenum comprises an outlet baffle capable of directing hot gases from the airfoil interior cavity. The airfoil anti-icing method of this invention comprises providing hot gases such as jet engine bleed air to the airfoil assembly of this invention, swirling the hot gases within the airfoil interior cavity, and discharging the hot gases from the airfoil interior cavity through the airfoil outlet end.

Abstract: A tabletop has sections that are relatively movable to positions in which the tabletop is configured to support a patient in a generally kneeling prone position suitable for lumbar examination. An angular section of the tabletop has a torso support surface configured to receive the patient's torso when the patient is in the generally kneeling prone position. The angular section further has a leg support surface configured to receive the patient's upper legs when the patient is in the generally kneeling prone position. The torso and leg support surfaces of the angular section of the tabletop have a permanently fixed angular orientation relative to each other and face upward in directions that diverge from each other. This configuration of the angular section enables the tabletop to impart an especially accessible orientation to the patient's lumbar vertebrae.

Abstract: An apparatus for reeling web or strand-like material comprises sensing means for sensing the tension in the material to be reeled, a separate non-driven control cylinder which has a non-slip surface around which the material is to pass, the control cylinder having brake means acting thereon under control means responsive to the sensing means.

Abstract: Multiple sets of parallel flat resilient conductive switch blades arranged side-by-side support opposed contact pairs and in turn are cantilever supported by engagement of each blade at a position remote from its contact area in an insulating wall of a relatively rigid support frame. One of the blades of each pair is moved by actuator means engaging the end remote from the point of support. The actuator means rotatably supported on the frame provides a slot which closely engages the ends of at least some of the blades essentially in the plane of the slot so that actuator rotation opens and closes supported contacts.