Abstract: The present disclosure provides, inter alia, chimeric nanobody compositions that selectively modulate the function of a target protein within a defined population of cells. Also provided are methods for treating diseases such as ion channelopathies.

Abstract: The present invention is a portable vehicle barrier, which is used to easily and effectively block vehicle access to restricted areas. The present invention comprises a front base, a rear base, spikes, and multiple folding arms. The folding arms are used to connect individual barriers to form a larger barrier so they can block small or large areas as needed. The spikes drive into the ground slowing oncoming vehicles and eventually stopping them as the barrier cantilevers intruding vehicles on the front base. For storage and transportation the folding arms can be folded to rest alongside the front base and rear base, while the rear base can be folded to rest atop the front base. A plurality of arm housings are located along the front and rear base, and are use to secure the folding arms in the deployed or storage states.