Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: Controllable bandwidth IF filter circuit for radio receivers generally, but having particular application to quadraphonic radio receivers intended for use in a quadraphonic system that is compatible with existing monophonic and biphonic equipment, said filter circuit being automatically adjusted in a digital manner to exhibit one of several different bandwidths in response to a pair of transmitted control signals present in the quadraphonic transmission so as to provide optimum receiver operation for the particular mode of broadcast being received, especially in terms of an improved protection ratio and signal to noise ratio for the received signal. The noted bandwidth adjustments are accomplished by modifying the values for certain of the component in the filter's tuned circuit and coupling sections through their selective connection into the circuit by means of semiconductor switching devices operated in response to said pair of control signals.