Patents by Inventor Henry Paulson

Henry Paulson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA interference suppression of neurodegenerative diseases and methods of use
    Patent number: 10072264
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: September 11, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
  • RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF
    Publication number: 20170335318
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Application
    Filed: December 30, 2016
    Publication date: November 23, 2017
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
  • siRNA-mediated gene silencing
    Patent number: 9487779
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: November 8, 2016
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Henry Paulson, Victor Miller, Cynthia Gouvion
  • RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF
    Publication number: 20160281084
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Application
    Filed: November 3, 2015
    Publication date: September 29, 2016
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
  • RNA interference suppression of neurodegenerative diseases and methods of use thereof
    Patent number: 9260716
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: February 16, 2016
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
  • siRNA-MEDIATED GENE SILENCING
    Publication number: 20160040159
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
    Type: Application
    Filed: June 5, 2014
    Publication date: February 11, 2016
    Inventors: Beverly L. Davidson, Henry Paulson, Victor Miller, Cynthia Gouvion
  • RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF
    Publication number: 20140287492
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Application
    Filed: June 18, 2013
    Publication date: September 25, 2014
    Applicant: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
  • SiRNA-mediated gene silencing
    Patent number: 8779116
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: July 15, 2014
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Henry Paulson, Victor Miller, Cynthia Gouvion
  • RNA interference suppresion of neurodegenerative diseases and methods of use thereof
    Patent number: 8524879
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Grant
    Filed: May 5, 2010
    Date of Patent: September 3, 2013
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan L. Boudreau, Scott Harper
  • RNA interference suppression of neurodegenerative diseases and methods of use thereof
    Patent number: 8481710
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Grant
    Filed: December 9, 2010
    Date of Patent: July 9, 2013
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
  • SiRNA-mediated gene silencing
    Patent number: 8329890
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: December 11, 2012
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Henry Paulson, Victor Miller, Cynthia Gouvion
  • siRNA-MEDIATED GENE SILENCING
    Publication number: 20110244561
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
    Type: Application
    Filed: November 23, 2010
    Publication date: October 6, 2011
    Applicant: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Henry Paulson, Victor Miller, Cynthia Gouvion
  • RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF
    Publication number: 20110212520
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Application
    Filed: December 9, 2010
    Publication date: September 1, 2011
    Applicant: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
  • RNA INTERFERENCE SUPPRESION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF
    Publication number: 20110111491
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Application
    Filed: May 5, 2010
    Publication date: May 12, 2011
    Applicant: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Henry Paulson, Ryan Boudreau, Scott Harper, Haibin Xia, Qinwen Mao
  • ALLELE-SPECIFIC SILENCING OF DISEASE GENES
    Publication number: 20090105169
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
    Type: Application
    Filed: May 26, 2003
    Publication date: April 23, 2009
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Victor Miller, Henry Paulson, Pedro Gonzalez-Alegre, Scott Harper
  • Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof
    Publication number: 20080274989
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Application
    Filed: June 2, 2005
    Publication date: November 6, 2008
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Habin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau
  • Allele-specific silencing of disease genes
    Publication number: 20080176812
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
    Type: Application
    Filed: January 31, 2006
    Publication date: July 24, 2008
    Inventors: Beverly L. Davidson, Scott Harper, Pedro Gonzalez-Alegre, Victor Miller, Henry Paulson
  • Suppressing polyglutamine aggregation and toxicity
    Publication number: 20070244057
    Abstract: It has been discovered that CHIP suppresses polyglutamine aggregation and toxicity in transfected cell lines, primary neurons and a novel zebrafish model of disease. Accordingly, certain embodiments of the present invention provide methods for decreasing the formation of an inclusion or aggregation of a protein or for increasing the solubility of a protein in a cell, comprising increasing the amount of C-terminal heat shock protein 70-interacting protein (CHIP) or a functional subunit of CHIP in the cell. Additionally, certain embodiments of the present invention provide methods for treating a subject that has a neurodegenerative disease or preventing a neurodegenerative disease in a subject, comprising administering to the subject a treatment effective to increase the amount of CHIP, or a functional subunit thereof, in cells of the subject.
    Type: Application
    Filed: January 22, 2007
    Publication date: October 18, 2007
    Inventors: Henry Paulson, Victor Miller
  • RNA interference suppresion of neurodegenerative diseases and methods of use thereof
    Publication number: 20050042646
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Application
    Filed: June 2, 2004
    Publication date: February 24, 2005
    Inventors: Beverly Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau
  • siRNA-mediated gene silencing
    Publication number: 20040241854
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
    Type: Application
    Filed: December 16, 2003
    Publication date: December 2, 2004
    Inventors: Beverly L. Davidson, Henry Paulson, Victor Miller, Cynthia Gouvion