Abstract: The present invention relates to a tuneable clarinet barrel joint (1) for arrangement between the mouthpiece and the upper joint of a (Eb, D, C, A or Bb) clarinet, with a longitudinal axis (L) and a bore (100) which runs in the longitudinal axis (L), whereby the clarinet barrel joint (1) is comprised of an upper part (2) and a lower part (3), which are arranged for connection in the longitudinal axis (L), and provided with a set collar (4) for the connection of the upper part (2) and the lower part (3), by means of which the distance between the upper part (2) and the lower part (3) is adjustable, characterized in that the set collar (4) is connected to both the upper part (2) and the lower part (3) by means of screw threads (6, 7), whereby the said screw threads (6, 7) are pitched with opposing directions of rotation.

Abstract: The present invention relates to a tuneable clarinet barrel joint (1) for arrangement between the mouthpiece and the upper joint of a (Eb, D, C, A or Bb) clarinet, with a longitudinal axis (L) and a bore (100) which runs in the longitudinal axis (L), whereby the clarinet barrel joint (1) is comprised of an upper part (2) and a lower part (3), which are arranged for connection in the longitudinal axis (L), and provided with a set collar (4) for the connection of the upper part (2) and the lower part (3), by means of which the distance between the upper part (2) and the lower part (3) is adjustable, characterized in that the set collar (4) is connected to both the upper part (2) and the lower part (3) by means of screw threads (6, 7), whereby the said screw threads (6, 7) are pitched with opposing directions of rotation.

Abstract: The present invention relates to compositions (i.e., various organic small molecules as exemplified herein) and methods for the inhibition of protein splicing and especially relates to the inhibition of protein autosplicing of intein-containing proteins. Additionally, the present invention relates to the use of the inhibitors of protein splicing of the invention for the treatment of various diseases including but not limited to tuberculosis. Furthermore, the invention provides the first instance of small molecule inhibitors of protein splicing with drug-like characteristics.

Abstract: The present invention relates to methods of screening for modulators of Hedgehog peptide autoprocessing with methods that are useful in both in vivo and high-throughput in vitro systems. The present invention also relates to reagents identified by the methods of the present invention for use in the modulation of Hh autoprocessing, especially as they relate to the treatment of illnesses and diseases that are caused, at least in part, by the misregulation of Hh autoprocessing.

Abstract: The present invention relates to compositions (i.e., various organic small molecules as exemplified herein) and methods for the inhibition of protein splicing and especially relates to the inhibition of protein autosplicing of intein-containing proteins. Additionally, the present invention relates to the use of the inhibitors of protein splicing of the invention for the treatment of various diseases including but not limited to tuberculosis. Furthermore, the invention provides the first instance of small molecule inhibitors of protein splicing with drug-like characteristics.

Abstract: A new type of transgene system is disclosed which allows efficient protein expression in a target host such as a plant, but avoids the undesirable result of the migration of the transgene into related host system and/or to the environment via the pollen. The methods described herein may also be applied to the expression of virtually any protein of interest (e.g. a toxic protein) in eukaryotic (yeast, insect, mammalian cells, etc.) and prokaryotic (E. coli, etc.) organisms.

Abstract: A new type of transgene system is disclosed which allows efficient protein expression in a target host such as a plant, but avoids the undesirable result of the migration of the transgene into related host systems and/or to the environment via the pollen. The methods described herein may also be applied to the expression of virtually any protein of interest (e.g. a toxic protein) in eukaryotic (yeast, insect, mammalian cells, etc.) and prokaryotic (E. coli, etc.) organisms.

Abstract: Disclosed are methods for the production of second generation catalytic antibodies. The disclosed methods offer a variety of advantages relative to prior art techniques. For example, the methods of the present invention do not require prior identification of the active site of an enzyme, the activity of which is desired in the catalytic antibody. Additionally, the disclosed methods enable the production of antibodies which catalyze chemical reactions which do not occur in nature.