Abstract: A registration alignment system to be used with a printed circuit board drilling machine for registration of PCBs on the tooling plate for drilling and other operations. The registration alignment system includes a registration bar and a registration block that move independently of each other. The movement of the registration bar is constrained to one dimension (i.e., X-axis), and the movement of the registration block is constrained to one dimension (i.e., Y-axis) that is perpendicular to the axis of movement of the registration bar. The registration bar and block contact adjusting screws which are used to control precise movement of the registration bar and block. When the registration pins of the PCB are in position against the registration bar and block, the pins are held in place by clamping bars. When the size of the registration pins change, the registration of the new PCB is still correct and does not have to be adjusted.