Patents by Inventor Henry Raphael Wolfe

Henry Raphael Wolfe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide-chelate conjugates
    Patent number: 7608242
    Abstract: A peptide-chelate conjugate with affinity for the ST receptor is disclosed, wherein the chelate is tetradentate. The peptide-chelate conjugate of the invention may be labelled with a radiometal to provide a metal complex. A radiopharmaceutical composition comprising the metal complex is provided. which is suitable for the diagnostic imaging of colorectal cancer. Also provided for in the invention is a kit for the preparation of the radiopharmaceutical preparation.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: October 27, 2009
    Assignee: GE Healthcare Limited
    Inventors: Alan Cuthbertson, Marivi Mendizabal, Mark Dixon, Anthony E. Storey, Edward R. Bacon, Vinay Chandrakant Desai, Sudhakar Kasina, Henry Raphael Wolfe
  • Lipopeptide stabilized microbubbles as diagnostic/therapeutic agents
    Patent number: 6548048
    Abstract: Novel membrane-forming amphiphilic lipopeptides comprising one or more peptide moieties containing 2-50 aminoacyl residues and one or more hydrocarbon chains containing 5-50 carbon atoms. Such lipopeptides may be used in the formation of stabilized gas microbubble dispersions suitable for use as diagnostic and/or therapeutic agents, for example as ultrasound contrast agents.
    Type: Grant
    Filed: October 25, 2000
    Date of Patent: April 15, 2003
    Assignee: Amersham Health AS
    Inventors: Alan Cuthbertson, Magne Solbakken, Henry Raphael Wolfe
  • Use of acousto-optical and sonoluminescene contrast agents
    Patent number: 6424857
    Abstract: The invention relates inter alia to a method of generating information from an animate human or non-human animal body which method comprises: administering to said body a physiologically tolerable material capable of absorbing, scattering or emitting light at a wavelength in the range 300 to 1300 nm; subjecting at least a portion of said body to ultrasound irradiation; detecting light in the wavelength range 300 to 1300 nm from said portion of said body; and manipulating the detected light to generate said information.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: July 23, 2002
    Assignee: Amersham Health AS
    Inventors: Paul Mark Henrichs, Henry Raphael Wolfe