Patents by Inventor Henry Shion

Henry Shion has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Difluoroacetic acid ion pairing reagent for high sensitivity, high resolution LC-MS of biomolecules and small molecules
    Patent number: 11478727
    Abstract: The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. The mobile phase includes about 0.005% (v/v) to about 2.50% (v/v) difluoroacetic acid and less than about 100 ppb of any individual impurity, especially metal impurities. A sample including the analyte is injected into the mobile phase. The analyte is separated from the sample.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: October 25, 2022
    Assignee: Waters Technologies Corporation
    Inventors: Matthew A. Lauber, Jennifer M. Nguyen, Ximo Zhang, Nilini Ranbaduge, Robert Birdsall, Henry Shion, Melvin Blaze Muttikal Thomas, Thomas Walter
  • Difluoroacetic acid ion pairing reagent for high sensitivity, high resolution LC-MS of biomolecules
    Patent number: 11433320
    Abstract: The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. The mobile phase includes about 0.005% (v/v) to about 0.20% (v/v) difluoroacetic acid and less than about 100 ppb of any individual metal impurity. A sample including the analyte is injected into the mobile phase. The analyte is separated from the sample.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: September 6, 2022
    Assignee: Waters Technologies Corporation
    Inventors: Matthew A. Lauber, Jennifer M. Nguyen, Ximo Zhang, Nilini Ranbaduge, Robert Birdsall, Henry Shion
  • DIFLUOROACETIC ACID ION PAIRING REAGENT FOR HIGH SENSITIVITY, HIGH RESOLUTION LC-MS OF BIOMOLECULES AND SMALL MOLECULES
    Publication number: 20200261826
    Abstract: The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. The mobile phase includes about 0.005% (v/v) to about 2.50% (v/v) difluoroacetic acid and less than about 100 ppb of any individual impurity, especially metal impurities. A sample including the analyte is injected into the mobile phase. The analyte is separated from the sample.
    Type: Application
    Filed: April 14, 2020
    Publication date: August 20, 2020
    Applicant: Waters Technologies Corporation
    Inventors: Matthew A. Lauber, Jennifer M. Nguyen, Ximo Zhang, Nilini Ranbaduge, Robert Birdsall, Henry Shion, Melvin Blaze Muttikal Thomas, Thomas Walter
  • DIFLUOROACETIC ACID ION PAIRING REAGENT FOR HIGH SENSITIVITY, HIGH RESOLUTION LC-MS OF BIOMOLECULES
    Publication number: 20190232197
    Abstract: The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. The mobile phase includes about 0.005% (v/v) to about 0.20% (v/v) difluoroacetic acid and less than about 100 ppb of any individual metal impurity. A sample including the analyte is injected into the mobile phase. The analyte is separated from the sample.
    Type: Application
    Filed: January 28, 2019
    Publication date: August 1, 2019
    Applicant: Waters Technologies Corporation
    Inventors: Matthew A. Lauber, Jennifer M. Nguyen, Ximo Zhang, Nilini Ranbaduge, Robert Birdsall, Henry Shion