Publication number: 20070032433
Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
Type:
Application
Filed:
January 18, 2002
Publication date:
February 8, 2007
Inventors:
Anil Saksena, Viyyoor Girijavallabhan, Raymond Lovey, Edwin Jao, Frank Bennett, Jinping Mc Cormick, Haiyan Wang, Russell Pike, Stephane Bogen, Tin-Yau Chan, Yi-Tsung Liu, Zhaoning Zhu, F. Njoroge, Ashok Arasappan, Tejal Parekh, Ashit Ganguly, Kevin Chen, Srikanth Venkatraman, Henry Vaccaro, Patrick Pinto, Bama Santhanam, Scott Kemp, Odile Levy, Marguerita Lim-wilby, Susan Tamura, Wanli Wu, Siska Hendrata, Yuhua Huang, Jesse Wong, Latha Nair
Publication number: 20070015807
Abstract: Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt thereof, wherein: M1 and M3 are CH or N; M2 is CH, CF or N; Y is —C(?O)—, —C(?S)—, —(CH2)q—, —C(?NOR7)— or —SO1-2—; Z is a bond or optionally substituted alkylene or alkenylene; R1 is H, or alkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, all optionally substituted, or a group of the formula: where ring A is a heteroaryl ring; R2 is optionally substituted alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; R3 is H, —C(O)NH2, or alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl, all optionally substituted; and the remaining variables are as defined in the specification; compositions and methods of treating allergy-induced airway responses, congestion, obesity, metabolic syndrome, alcoholic fatty liver disease, hepatic steatosis, nonalcoholic steatohepatitis, cirrhosis, hepatacellular carcinoma and cognition deficit disorders using said compounds, alone or in combination with other age
Type:
Application
Filed:
June 19, 2006
Publication date:
January 18, 2007
Inventors:
Robert Aslanian, Michael Berlin, Christopher Boyce, Jianhua Chao, Manuel de Lera Ruiz, Pietro Mangiaracina, Kevin McCormick, Mwangi Mutahi, Stuart Rosenblum, Neng-Yang Shih, Daniel Solomon, Wing Tom, Henry Vaccaro, Junying Zheng, Xiaohong Zhu
Publication number: 20060205672
Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
Type:
Application
Filed:
September 30, 2005
Publication date:
September 14, 2006
Applicants:
Schering Corporation, Dendreon Corporation
Inventors:
Anil Saksena, Viyyoor Girijavallabhan, Raymond Lovey, Edwin Jao, Frank Bennett, Jinping McCormick, Haiyan Wang, Russell Pike, Stephane Bogen, Tin-Yau Chan, Yi-Tsung Liu, Zhaoning Zhu, F. Njoroge, Ashok Arasappan, Tejal Parekh, Ashit Ganguly, Kevin Chen, Srikanth Venkatraman, Henry Vaccaro, Patrick Pinto, Bama Santhanam, Scott Kemp, Odile Levy, Marguerita Lim-Wilby, Susan Tamura, Wanli Wu, Siska Hendrata, Yuhua Huang