Abstract: Electrochemical sensors for measurement of an analyte comprising an analyte sensing membrane comprising at least one salt of acetate ion, carbonate ion, bicarbonate ion, or mixtures thereof. Sensor testing methods comprising contacting an electrochemical sensor with an aqueous solution comprising at least one salt of acetate ion, carbonate ion, bicarbonate ion, or mixtures thereof and contacting the electrochemical sensor with one or more concentrations of analyte, the one or more concentrations of analyte being in the clinical concentration range of the analyte.

Abstract: Sensors for measuring an analyte in a subject comprising at least one electrode having an electroactive surface, at least one interferent-reducing layer comprising vinyl ester monomeric units disposed distally from the electroactive surface, an enzyme layer disposed distally from the electroactive surface and a flux-limiting membrane disposed over the at least one interferent-reducing layer and the enzyme layer. Methods of measuring an analyte in a subject comprising providing the electrochemical analyte sensor, contacting a sample comprising an analyte and an interferent with the at least one interferent-reducing layer comprising vinyl ester monomeric units, and measuring the analyte, where the amount of interferent reaching the electroactive surface is reduced.

Abstract: Methods and systems for preventing or eliminating thrombus during use of a sensor are disclosed. The method comprises providing a calibrant infusion fluid source comprising a predetermined amount of a calibrant and adding a predetermined amount of a non-heparin anti-thrombotic agent into the calibrant infusion fluid source. A system and method is disclosed that includes an infusion calibrant source comprising a predetermined amount of a calibrant and a predetermined amount of a non-heparin anti-thrombotic agent with a glucose sensor.

Abstract: Electrochemical sensors for measuring an analyte in a subject are described. More particularly, devices for measurement of an analyte incorporating a sensor comprising a hydrophilic polymer-enzyme composition covering an electroactive surface providing rapid and accurate analyte levels upon deployment are disclosed.

Abstract: Measurements of current from a working electrode and current from a blank electrode are received and a ratio corresponding to the ratio of surface areas of the working electrode and the blank electrode is determined. This ratio is used to correct any differential current offset between an analyte (working) electrode and a control (blank) electrode to yield a more accurate net current output. Systems, methods and computer program products are further described for measuring an analyte concentration disclosed are for calculating the amount of an analyte in a fluid using a biosensor.

Abstract: A method comprising providing an in vivo electrochemical biosensor, the biosensor comprising an electrode surface, a flux-limiting layer covering at least a portion of the electrode surface, covering at least a portion of the flux-limiting layer with a hydrophilic polymer membrane, and preventing or eliminating disruption of the output signal of the electrochemical biosensor by an external EMF or external RF source during in vivo use of the biosensor in a subject.

Abstract: Disclosed herein is an electrochemical sensor for measuring an analyte in a subject. More particularly, sensors comprising a polyelectrolyte layer at least partially covering the electroactive surface of an electrode are disclosed.

Abstract: Electrochemical sensors for measuring an analyte in a subject are described. More particularly, devices for measurement of an analyte are disclosed incorporating a sensor comprising an enzyme layer in contact with an interference layer and a membrane comprising vinyl ester monomeric units covering at least a portion of the enzyme layer and at least a portion of the interference layer, the devices providing rapid and accurate analyte levels upon deployment.

Abstract: The present invention provides processes for fixation of biological tissue and/or post-fixation treatment of such tissue that result in modified tissues with reduced susceptibility to in vitro calcification when used in prosthetic devices. The invention also relates to calcification resistant biological tissue and to methods of using such tissue.

Abstract: A composite insulator containing means for providing early warning of impending failure due to stress corrosion cracking, flashunder, or destruction of the rod by discharge activity conditions is described. A composite insulator comprising a fiberglass rod surrounded by a polymer housing and connected with metal end fittings on either end of the rod is doped with a dye-based chemical dopant. The dopant is located around the vicinity of the outer surface of the fiberglass rod. The dopant is formulated to possess migration and diffusion characteristics, and to be inert in dry conditions and compatible with the insulator components. The dopant is positioned within the insulator such that upon the penetration of moisture through the housing to the rod through a permeation pathway in the outer surface of the insulator, the dopant will become activated and will leach out of the same permeation pathway or diffuse through the housing.

Abstract: A device for inserting a flexible intraocular lens into an eye including a tubular member and a plunger. The tubular member includes a staging area, a lumen, and an open distal end. The staging area supports the lens in an unstressed state prior to engagement by the plunger. In the unstressed state, the optic of the lens is suspended in a pocket to avoid any substantial contact with interior portions of the tubular member. The plunger includes a slot in its distal tip for receiving and gripping the lens. With this construction, the lens can be inserted into the eye in one continuous motion. Further, the plunger holds the lens when the lens is moved out of the tubular member.

Abstract: This invention is a device for inserting a flexible intraocular lens (12) into an eye comprising a tubular member (16) and a plunger (18). The tubular member includes a staging area (45), a lumen, and an open distal end (95). The staging area supports unstressed state prior to engagement by the plunger. In the unstressed state, the optic (48) of the lens is suspended in a pocket to avoid any substantial contact with interior portions of the tubular member. The plunger includes a slot (132) in its distal tip fo receiving and gripping the lens. With this construction, the lens can be inserted into the eye in one continuous motion. Further, the plunger holds the lens when the lens is moved out of the tubular member.

Abstract: This invention is a device for inserting a flexible intraocular lens (12) into an eye comprising a tubular member (16) and a plunger (18). The tubular member includes a staging area (45), a lumen, and an open distal end (95). The staging area support unstressed state prior to engagement by the plunger. In the unstressed state, the optic (48) of the lens is suspended in a pocket to avoid substantial contact with interior portions of the tubular member. The plunger includes a slot (132) in its distal tip fo receiving and gripping the lens. With this construction, the lens can be inserted into the eye in one continuous motion. Further, the plunger holds the lens when the lens is moved out of the tubular member.

Abstract: An intraocular lens insertion device having a tubular member for receiving the lens and a plunger for pushing the lens into the eye. The lens is held in a suspended position by its haptics so that the optic portion of the lens does not contact the interior of the tubular member. The plunger tip is provided with a slot for holding the lens after it is expelled from the tubular member into the eye in order to alleviate the risks associated with uncontrolled unfolding of the lens or uncontrolled expulsion of the lens from the inserter into the eye.

Abstract: The preparation of particular fluorescent silane dye compositions is disclosed. These silane dye compositions have particular utility as reactants in the preparation of silicone polymeric fluorescent dyes which can be ideally used as chemical indicators in biological sensors.