Patents by Inventor Henry W. Querfurth

Henry W. Querfurth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE
    Publication number: 20220347136
    Abstract: Provided are compositions and methods useful for sensitizing a neuron to insulin or insulin-like growth factor 1 (IGF-1), wherein the neuron is resistant to either insulin or IGF-1. Also provided are compositions and method useful for inhibiting intracellular beta amyloid peptide A?42-mediated decrease in neuronal viability. Also provided are compositions and methods useful for improving synaptic plasticity. Also provided are compositions and methods useful for improving learning and memory. In certain embodiments, the composition comprises (Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid (PS48). In certain embodiments, the method comprises contacting a neuron with PS48. In certain embodiments, the method comprises administering an effective amount of PS48 to a subject in need thereof.
    Type: Application
    Filed: April 8, 2022
    Publication date: November 3, 2022
    Inventor: Henry W. Querfurth
  • Methods and compositions for treating alzheimer's disease
    Patent number: 9618511
    Abstract: Aspects of the invention relate to methods and compositions for treating Alzheimer's disease (AD). In some embodiments, the invention provides methods for screening and identifying compounds that selectively inhibit the targeting of the insulin-Akt signaling pathway by A? oligomers.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: April 11, 2017
    Assignee: Eleanore Bennett Charitable Trust #2
    Inventor: Henry W. Querfurth
  • METHODS AND COMPOSITIONS FOR TREATING ALZHEIMER'S DISEASE
    Publication number: 20150247857
    Abstract: Aspects of the invention relate to methods and compositions for treating Alzheimer's disease (AD). In some embodiments, the invention provides methods for screening and identifying compounds that selectively inhibit the targeting of the insulin-Akt signaling pathway by A? oligomers.
    Type: Application
    Filed: January 30, 2015
    Publication date: September 3, 2015
    Applicant: Eleanore Bennett Charitable Trust #2
    Inventor: HENRY W. QUERFURTH
  • Methods and compositions for treating alzheimer's disease
    Patent number: 8969023
    Abstract: Aspects of the invention relate to methods and compositions for treating Alzheimer's disease (AD). In some embodiments, the invention provides methods for screening and identifying compounds that selectively inhibit the targeting of the insulin-Akt signaling pathway by A? oligomers.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: March 3, 2015
    Assignee: Eleanore Bennett Charitable Trust #2
    Inventor: Henry W. Querfurth
  • METHODS AND COMPOSITIONS FOR TREATING ALZHEIMER'S DISEASE
    Publication number: 20110165598
    Abstract: Aspects of the invention relate to methods and compositions for treating Alzheimer's disease (AD). In some embodiments, the invention provides methods for screening and identifying compounds that selectively inhibit the targeting of the insulin-Akt signaling pathway by A? oligomers.
    Type: Application
    Filed: June 10, 2009
    Publication date: July 7, 2011
    Inventor: Henry W. Querfurth
  • Methods of and systems and devices for assessing intracranial pressure non-invasively
    Patent number: 7122007
    Abstract: A non-invasive method and system for assessing intraocular pressure (ICP) is disclosed. The method comprises the steps of measuring venous outflow pressure (VOP) using a venous ophthalmodynamometer device (vODM); measuring ophthalmic r central retinal arterial blood flow using color Doppler imaging device; and then estimating ICP using venous outflow data from the vODM and pulsatility and/or resistivity relationships derived from the Doppler imaging data. Further disclosed is a novel vODM for measuring VOP in low flow veins.
    Type: Grant
    Filed: May 12, 2003
    Date of Patent: October 17, 2006
    Assignee: Caritas St. Elizabeth Medical Center of Boston, Inc.
    Inventor: Henry W. Querfurth
  • Methods of and systems and devices for assessing intracranial pressure non-invasively
    Publication number: 20040230124
    Abstract: A non-invasive method and system for assessing intraocular pressure (ICP) is disclosed. The method comprises the steps of measuring venous outflow pressure (VOP) using a venous ophthalmodynamometer device (vODM); measuring ophthalmic r central retinal arterial blood flow using color Doppler imaging device; and then estimating ICP using venous outflow data from the vODM and pulsatility and/or resistivity relationships derived from the Doppler imaging data. Further disclosed is a novel vODM for measuring VOP in low flow veins.
    Type: Application
    Filed: May 12, 2003
    Publication date: November 18, 2004
    Inventor: Henry W. Querfurth