Abstract: The present disclosure provides compounds and compositions thereof which are useful as inhibitors of tyrosine kinase and which exhibit desirable characteristics for the same. Further disclosed herein are methods of treating cancer using these tyrosine kinase inhibitor compounds.

Abstract: A chemical injection system. The chemical injection system includes at least two Venturi injectors in parallel. Each of the Venturi injectors having an injector housing with a longitudinal cavity having the shape of hourglass. One end of the longitudinal cavity forms an injector inlet, and the other end forms an injector outlet. Each of the injector housings also has a first vertical cavity forming an injector port located at the hourglass constriction. The injector inlets are fluidly coupled together to form a shared injector input and each of the injector ports is fluidly coupled to an individual valve. Each of the injector outlets is fluidly coupled to the input a separate T-filter and the outputs of the T-filters are fluidly coupled together to form shared T-filter output.

Abstract: A system for maintaining individual immunization records. The system includes a tracking vehicle storing a first instance of a user record a terminal including an electronic processor and a memory. The electronic processor is configured to communicate with the tracking vehicle, obtain a second instance of the user record stored in the memory of the terminal and determine whether immunization data in the first instance or the second instance is more recent. When the first instance of the user record from the tracking vehicle includes more recent immunization data than the second instance of the user record stored in the memory, the electronic processor is configured to update the user record stored in the memory of the terminal with the more recent immunization data in the first instance of the user record of the tracking vehicle.

Abstract: A toothpaste dispensing toothbrush having a motorized based that provides one-handed use and an audible measuring device are described herein.

Abstract: A digital sight for a weapon, is provided that includes an adjustable power supply (APS) configured to supply power, a sight body, a sight interface, and a controller. The sight interface is fixed to the sight body, includes a sight power conductor connected to the APS for receiving power supplied by the APS, and is configured for mechanically coupling with a cooperating peripheral interface of a peripheral for fixing the peripheral to the digital sight and to be coupled with a peripheral power conductor of the peripheral interface for providing power from the adjustable power supply to the peripheral. The controller is programmed to receive a data communication having an optimal power indication from the peripheral and based on the optimal power indication, control the APS to adjust the power supplied by the APS to the sight power conductor. The disclosure further encompasses a weapon assembly, a peripheral, and a method.

Abstract: A tactical rail for a firearm includes a rail body having a receiver end and a muzzle end, a non-contact optical connection, and a high speed data spoke. The non-contact optical connection is arranged at an end of the rail body and is configured to interface with a corresponding non-contact optical interface. The high speed data spoke is connected to the non-contact optical connection for high speed data communication through the non-contact optical connection and the corresponding non-contact optical interface. Tactical rail arrangements and firearm with tactical rails and tactical rail arrangements are also described.

Abstract: A digital sight for a weapon, is provided that includes an adjustable power supply (APS) configured to supply power, a sight body, a sight interface, and a controller. The sight interface is fixed to the sight body, includes a sight power conductor connected to the APS for receiving power supplied by the APS, and is configured for mechanically coupling with a cooperating peripheral interface of a peripheral for fixing the peripheral to the digital sight and to be coupled with a peripheral power conductor of the peripheral interface for providing power from the adjustable power supply to the peripheral. The controller is programmed to receive a data communication having an optimal power indication from the peripheral and based on the optimal power indication, control the APS to adjust the power supplied by the APS to the sight power conductor. The disclosure further encompasses a weapon assembly, a peripheral, and a method.

Abstract: A system for maintaining individual immunization records. The system includes a tracking vehicle storing a first instance of a user record a terminal including an electronic processor and a memory. The electronic processor is configured to communicate with the tracking vehicle, obtain a second instance of the user record stored in the memory of the terminal and determine whether immunization data in the first instance or the second instance is more recent. When the first instance of the user record from the tracking vehicle includes more recent immunization data than the second instance of the user record stored in the memory, the electronic processor is configured to update the user record stored in the memory of the terminal with the more recent immunization data in the first instance of the user record of the tracking vehicle.

Abstract: A tactical rail for a firearm includes a rail body having a receiver end and a muzzle end, a non-contact optical connection, and a high speed data spoke. The non-contact optical connection is arranged at an end of the rail body and is configured to interface with a corresponding non-contact optical interface. The high speed data spoke is connected to the non-contact optical connection for high speed data communication through the non-contact optical connection and the corresponding non-contact optical interface. Tactical rail arrangements and firearm with tactical rails and tactical rail arrangements are also described.

Abstract: A container has a paperboard outer shell and an inner lining. The container also has a main body portion, a neck portion providing an opening of the container and a base on which the container may be supported in use. The outer shell has a first side wall element including a part of the neck portion and a part of the main body portion of the container; a second side wall element including a part of the neck portion and a part of the main body portion of the container; and a third base element including the base of the container. The first, second and third elements are separate elements bonded together to form the shell, and are formed from flat sheet material pressed to form the 3-dimensional shape of the shell.

Abstract: In one aspect, the present disclosure relates to a motorized tie-down device having a housing, a flexible strap having a first end attached to a reel, and a carabiner attached to a second end of the flexible strap. The housing can include a power supply comprising one or more rechargeable batteries, an electric motor coupled to receive power from the power supply, a control to activate the electric motor, the reel, and a worm drive assembly operatively coupled to the electric motor and the reel and configured to transfer rotation from the electric motor to the reel.

Abstract: A digital sight for a weapon, is provided that includes an adjustable power supply (APS) configured to supply power, a sight body, a sight interface, and a controller. The sight interface is fixed to the sight body, includes a sight power conductor connected to the APS for receiving power supplied by the APS, and is configured for mechanically coupling with a cooperating peripheral interface of a peripheral for fixing the peripheral to the digital sight and to be coupled with a peripheral power conductor of the peripheral interface for providing power from the adjustable power supply to the peripheral. The controller is programmed to receive a data communication having an optimal power indication from the peripheral and based on the optimal power indication, control the APS to adjust the power supplied by the APS to the sight power conductor. The disclosure further encompasses a weapon assembly, a peripheral, and a method.

Abstract: A tactical rail for a firearm includes a rail body having a receiver end and a muzzle end and a non-contact optical connection arranged at an end of the rail body and configured to interface with a corresponding non-contact optical interface. A low speed data bus segment extends between the receiver end and the muzzle end of the rail body. A high speed data spoke is connected to the non-contact optical connection for high speed data communication with a high speed data accessory through the non-contact optical connection and the corresponding non-contact optical interface. Tactical rail systems and firearm assemblies having tactical rails are also described.

Abstract: A tactical rail for a firearm includes a rail body having a receiver end and a muzzle end, a non-contact optical connection, and a high speed data spoke. The non-contact optical connection is arranged at an end of the rail body and is configured to interface with a corresponding non-contact optical interface. The high speed data spoke is connected to the non-contact optical connection for high speed data communication through the non-contact optical connection and the corresponding non-contact optical interface. Tactical rail arrangements and firearm with tactical rails and tactical rail arrangements are also described.

Abstract: A vertical docking apparatus (VDA) includes a back panel assembly with at least a first device docking hook (DDH) and a first panel mounting cavity. The first panel mounting cavity is located on a back surface of the back panel assembly and configured to allow the back panel assembly to be mounted to a vertical surface. Additionally, the VDA includes a front panel assembly that is attached to the back panel assembly, a first DDH cavity that is adapted to receive the first DDH, and a transmission connector.

Abstract: A rim assembly for a container comprises a frame member (346) having a perimeter corresponding in shape to an opening of a container such that, in use, the frame member is received within the opening and extends around an interior surface of a side wall of the container; a plurality of securing tabs (394) hingedly connected to the frame member (346), each tab (394) including an engagement member (396); sealing means configured for repeated sealing engagement with a lid of the container; and retaining means (399), wherein each of the securing tabs is movable between a first position in which the engagement member is disengaged from an aperture (317) in the container side wall and a second position in which the engagement member (396) is engaged with one of the apertures (317) in the side wall, and wherein the retaining means is configured to retain the securing tabs in the second position such that the rim assembly is secured to the container around a top edge of the side wall.

Abstract: A toothpaste dispensing toothbrush having a motorized based that provides one-handed use and an audible measuring device are described herein.