Patents by Inventor Henry Wolfe

Henry Wolfe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160362444
    Abstract: This application is directed to the use of steroid compounds for the selective inhibition of the enzyme PTP1B in a mammal for the treatment of diabetes.
    Type: Application
    Filed: June 9, 2016
    Publication date: December 15, 2016
    Applicant: Ohr Pharmaceutical Inc.
    Inventors: Michael McLane, Inez Ruiz-White, Henry Wolfe
  • Patent number: 9365608
    Abstract: This application is directed to the use of steroid compounds for the selective inhibition of the enzyme PTP1B in a mammal for the treatment of diabetes.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: June 14, 2016
    Assignee: Ohr Pharmaceutical, Inc.
    Inventors: Michael McLane, Inez Ruiz-White, Henry Wolfe
  • Publication number: 20140322302
    Abstract: Therapeutic peptides having guanylyl cyclase C agonist activity are disclosed. The therapeutic peptides are analogues of the E. coli STa peptide with non-natural amino acid, isosteric or D-amino acid substituents. The therapeutic peptides are useful in the treatment of chronic ideopathic constipation, inflammatory bowel disease, and other diseases. Pharmaceutical compositions comprising the therapeutic peptides are also disclosed.
    Type: Application
    Filed: May 11, 2014
    Publication date: October 30, 2014
    Applicant: COMBIMAB, INC
    Inventors: Henry Wolfe, Reinhard Ebner
  • Patent number: 8748575
    Abstract: Therapeutic peptides having guanylyl cyclase C agonist activity are disclosed. The therapeutic peptides are analogues of the E. coli STa peptide with non-natural amino acid, isosteric or D-amino acid substituents. The therapeutic peptides are useful in the treatment of chronic ideopathic constipation, inflammatory bowel disease, and other diseases. Pharmaceutical compositions comprising the therapeutic peptides are also disclosed.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: June 10, 2014
    Assignee: Combimab, Inc.
    Inventors: Henry Wolfe, Reinhard Ebner
  • Publication number: 20140038881
    Abstract: Therapeutic peptides having guanylyl cyclase C agonist activity are disclosed. The therapeutic peptides are analogues of the E. coli STa peptide with non-natural amino acid, isosteric or D-amino acid substituents. The therapeutic peptides are useful in the treatment of chronic ideopathic constipation, inflammatory bowel disease, and other diseases. Pharmaceutical compositions comprising comprising the therapeutic peptides are also disclosed.
    Type: Application
    Filed: June 8, 2011
    Publication date: February 6, 2014
    Applicant: COMBIMAB, INC
    Inventors: Henry Wolfe, Reinhard Ebner
  • Publication number: 20120308583
    Abstract: Proliferation of colorectal, gastric and esophageal cancer cells is inhibited by administering ST receptor ligand. The number of ST receptor molecules on the surface of a colorectal cell or metastasized colorectal cancer cell are increased by administering an ST receptor ligand such that ligand comes into contact with an ST receptor on the surface of the colorectal cell. Pharmaceutical compositions comprise sterile, pyrogen free ST receptor ligand and a pharmaceutically acceptable carrier or diluent. Metastasized colorectal cancer is treated or imaged by increasing the number of ST receptor molecules on the surface of a metastasized colorectal cancer cell and then administering a pharmaceutical composition containing components that target the ST receptor for delivery of a therapeutic agent or imaging agent. Methods of detecting metastasized colorectal cancer are disclosed. Methods of delivering active compounds to a colorectal cell in an individual are disclosed.
    Type: Application
    Filed: June 19, 2012
    Publication date: December 6, 2012
    Applicant: Thomas Jefferson University
    Inventors: Scott A. Waldman, Giovanni Mario Pitari, Jason Park, Stephanie Schulz, Henry Wolfe, Wilhelm Lubbe
  • Publication number: 20100324004
    Abstract: This application is directed to the use of steroid compounds for the selective inhibition of the enzyme PTP1B in a mammal for the treatment of diabetes.
    Type: Application
    Filed: September 8, 2008
    Publication date: December 23, 2010
    Inventors: Michael McLane, Inez Ruiz-White, Henry Wolfe
  • Patent number: 7575891
    Abstract: The present invention provides a method of purifying diphtheria toxin comprising (1) fermenting a microorganism strain capable of producing diphtheria toxin using glucose as a carbon source, said method comprising adding glucose to a growing culture whereby the addition of glucose maintains microorganism growth effective to support diphtheria toxin production; and (2) purifying the diphtheria toxin from the culture by contacting a toxin containing preparation derived therefrom with an ion exchange matrix, eluting a fraction containing the toxin, applying the eluate to a hydrophobic matrix, and eluting a fraction containing the toxin.
    Type: Grant
    Filed: September 13, 2007
    Date of Patent: August 18, 2009
    Assignee: GE Healthcare AS
    Inventors: Henry Wolfe, Fahar Merchant, Rosemina Merchant, Christopher Black, Harry Storflor, Geir Stokke, Halldis Hellebust
  • Publication number: 20080153750
    Abstract: The present invention provides a method of purifying diphtheria toxin comprising (1) fermenting a microorganism strain capable of producing diphtheria toxin using glucose as a carbon source, said method comprising adding glucose to a growing culture whereby the addition of glucose maintains microorganism growth effective to support diphtheria toxin production; and (2) purifying the diphtheria toxin from the culture by contacting a toxin containing preparation derived therefrom with an ion exchange matrix, eluting a fraction containing the toxin, applying the eluate to a hydrophobic matrix, and eluting a fraction containing the toxin.
    Type: Application
    Filed: September 13, 2007
    Publication date: June 26, 2008
    Inventors: Henry Wolfe, Fahar Merchant, Rosemina Merchant, Christopher Black, Harry Storflor, Geir Stokke, Halldis Hellebust
  • Publication number: 20080058300
    Abstract: The present invention is directed to the use of compound 1436 for the induction of weight loss in an obese mammal.
    Type: Application
    Filed: April 23, 2007
    Publication date: March 6, 2008
    Inventors: Michael McLane, Kristen Lantz, Susan Emeigh Hart, Andrew Albright, Hsiao-Ling Hung, Henry Wolfe
  • Patent number: 7273728
    Abstract: The present invention provides a method of purifying diphtheria toxin comprising (1) fermenting a microorganism strain capable of producing diphtheria toxin using glucose as a carbon source, the method comprising adding glucose to a growing culture whereby the addition of glucose maintains microorganism growth effective to support diphtheria toxin production; and (2) purifying the diphtheria toxin from the culture by contacting a toxin containing preparation derived therefrom with an ion exchange matrix, eluting a fraction containing the toxin, applying the eluate to a hydrophobic matrix, and eluting a fraction containing the toxin.
    Type: Grant
    Filed: August 15, 2005
    Date of Patent: September 25, 2007
    Assignee: GE Healthcare AS
    Inventors: Henry Wolfe, Fahar Merchant, Rosemina Merchant, Christopher Black, Harry Storflor, Geir Stokke, Halldis Hellebust
  • Publication number: 20060222593
    Abstract: A peptide-chelate with affinity for the ST receptor is disclosed, wherein the chelate is tetradentate. The peptide-chelate conjugate of the invention may be labelled with a radiometal to provide a metal complex. A radiopharmaccutical composition comprising the metal complex is provided, which is suitable for the diagnostic imaging of colorectal cancer. Also provided for in the invention is a kit for the preparation of the radiopharmaceutical preparation.
    Type: Application
    Filed: March 1, 2002
    Publication date: October 5, 2006
    Inventors: Alan Cuthbertson, Marivi Mendizabal, Mark Dixon, Anthony Storey, Edward Bacon, Vinay Desai, Sudahkar Kasina, Henry Wolfe
  • Publication number: 20060035340
    Abstract: The present invention provides a method of purifying diphtheria toxin comprising (1) fermenting a microorganism strain capable of producing diphtheria toxin using glucose as a carbon source, said method comprising adding glucose to a growing culture whereby the addition of glucose maintains microorganism growth effective to support diphtheria toxin production; and (2) purifying the diphtheria toxin from the culture by contacting a toxin containing preparation derived therefrom with an ion exchange matrix, eluting a fraction containing the toxin, applying the eluate to a hydrophobic matrix, and eluting a fraction containing the toxin.
    Type: Application
    Filed: August 15, 2005
    Publication date: February 16, 2006
    Inventors: Henry Wolfe, Fahar Merchant, Rosemina Merchant, Christopher Black, Harry Storflor, Geir Stokke, Halldis Hellebust
  • Patent number: 6962803
    Abstract: The present invention provides a method of purifying diphtheria toxin comprising (1) fermenting a microorganism strain capable of producing diphtheria toxin using glucose as a carbon source, said method comprising adding glucose to a growing culture whereby the addition of glucose maintains microorganism growth effective to support diphtheria toxin production; and (2) purifying the diphtheria toxin from the culture by contacting a toxin containing preparation derived therefrom with an ion exchange matrix, eluting a fraction containing the toxin, applying the eluate to a hydrophobic matrix, and eluting a fraction containing the toxin.
    Type: Grant
    Filed: October 22, 2003
    Date of Patent: November 8, 2005
    Assignee: Amersham Health AS
    Inventors: Henry Wolfe, Fahar Merchant, Rosemina Merchant, Christopher Black, Harry Storflor, Geir Stokke, Halldis Hellebust
  • Publication number: 20040258687
    Abstract: Proliferation of colorectal, gastric and esophageal cancer cells is inhibited by administering ST receptor ligand. The number of ST receptor molecules on the surface of a colorectal cell or metastasized colorectal cancer cell are increased by administering an ST receptor ligand such that ligand comes into contact with an ST receptor on the surface of the colorectal cell. Pharmaceutical compositions comprise sterile, pyrogen free ST receptor ligand and a pharmaceutically acceptable carrier or diluent. Metastasized colorectal cancer is treated or imaged by increasing the number of ST receptor molecules on the surface of a metastasized colorectal cancer cell and then administering a pharmaceutical composition containing components that target the ST receptor for delivery of a therapeutic agent or imaging agent. Methods of detecting metastasized colorectal cancer are disclosed. Methods of delivering active compounds to a colorectal cell in an individual are disclosed.
    Type: Application
    Filed: February 10, 2004
    Publication date: December 23, 2004
    Applicant: Thomas Jefferson University
    Inventors: Scott A. Waldman, Glovanni Mario Pitari, Jason Park, Stephanie Schulz, Henry Wolfe, Wilhelm Lubbe
  • Patent number: 6749554
    Abstract: A medical or surgical device or tool that is designed to be implanted or inserted inside the human or mammalian body, having at least part of its surface coated whereby the ultrasound visibility of said device or tool in vivo is enhanced, wherein the coating comprises one or more of the following: (i) a matrix material containing a plurality of contrast enhancing elements; (ii) magnesium; (iii) a liquid or polymer which alters its ultrasound imaging properties upon elevating the temperature from ambient to physiological temperature; (iv) a liquid or polymer which alters its ultrasound imaging properties as a result of a change in pH; (v) an essentially non-polymeric bio-compatible compound which forms a discontinuous coating. Preferably the device or tool is a radioactive source for use in brachytherapy, and in particular a radioactive seed.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: June 15, 2004
    Assignee: Amersham PLC
    Inventors: Robert Allen Snow, Henry Wolfe, Anna Rydbeck, Tore Gjorsvik, Steven Coffey, Hakan Malmgren, Oskar Axellson
  • Publication number: 20040087775
    Abstract: The present invention provides a method of purifying diphtheria toxin comprising (1) fermenting a microorganism strain capable of producing diphtheria toxin using glucose as a carbon source, said method comprising adding glucose to a growing culture whereby the addition of glucose maintains microorganism growth effective to support diphtheria toxin production; and (2) purifying the diphtheria toxin from the culture by contacting a toxin containing preparation derived therefrom with an ion exchange matrix, eluting a fraction containing the toxin, applying the eluate to a hydrophobic matrix, and eluting a fraction containing the toxin.
    Type: Application
    Filed: October 22, 2003
    Publication date: May 6, 2004
    Inventors: Henry Wolfe, Fahar Merchant, Rosemina Merchant, Christopher Black, Harry Storflor, Geir Stokke, Halldis Hellebust
  • Patent number: 6689871
    Abstract: The present invention provides a method of purifying diphtheria toxin comprising (1) fermenting a microorganism strain capable of producing diphtheria toxin using glucose as a carbon source, the method comprising adding glucose to a growing culture whereby the addition of glucose maintains microorganism growth effective to support diphtheria toxin production; and (2) purifying the diphtheria toxin from the culture by contacting a toxin containing preparation derived therefrom with an ion exchange matrix, eluting a fraction containing the toxin, applying the eluate to a hydrophobic matrix, and eluting a fraction containing the toxin.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: February 10, 2004
    Assignee: Amersham Health AS
    Inventors: Henry Wolfe, Fahar Merchant, Rosemina Merchant, Christopher Black, Harry Storflor, Geir Stokke, Halldis Hellebust
  • Publication number: 20020076378
    Abstract: The invention provides compounds comprising a linear, branched or dendrimeric polymer backbone with linked thereto at least one reporter moiety, said polymer backbone comprising a plurality of amine-containing acids. Such compounds may be linked to one or more targeting agents and are useful as therapeutic and diagnostic agents, in particular in medical imaging techniques.
    Type: Application
    Filed: January 29, 2002
    Publication date: June 20, 2002
    Applicant: NYCOMED IMAGING AS
    Inventors: Henry Wolfe, Kenneth Kellar
  • Patent number: D676565
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: February 19, 2013
    Inventor: Henry Wolfe