Patents by Inventor Henryk Dubicki

Henryk Dubicki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the production of 2-.beta.-D-ribofuranosylthiazole-4-carboxamide
    Patent number: 4451648
    Abstract: An improved multi-step process for the production of 2-.beta.-D-ribofuranosylthiazole-4-carboxamide.
    Type: Grant
    Filed: August 19, 1981
    Date of Patent: May 29, 1984
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jack L. Parsons, Dan Vizine, Mark Sumner, Suresh Marathe, Henryk Dubicki
  • Multi-step process for the production of methanesulfon-m-anisidide, 4'-(9-acridinylamino)-
    Patent number: 4258191
    Abstract: A multi-step method of producing the compound methanesulfon-m-anisidide, 4'-(9-acridinylamino)-, acetate (VII), which may be in free base form and designated NSC 249992, also known as AMSA. This compound is produced by an elegant process from a starting material, 4-butyrylamino-3-methoxy-nitrobenzene, which is later transformed to methanesulfon-m-anisidide, 4'-amino- (IV) and is coupled or joined to 9-chloro-acridine, producing the chloride salt which is later converted to the acetate.
    Type: Grant
    Filed: March 29, 1979
    Date of Patent: March 24, 1981
    Assignee: The United States of America as represented by the Secretary of Health, Education and Welfare
    Inventors: Henryk Dubicki, Jack L. Parsons, Fred W. Starks
  • Preparation of N-(phosphonoacetyl)-L-aspartic acid
    Patent number: 4154759
    Abstract: Improved methods for preparation of the tetrasodium and disodium salts of N-(phosphonoacetyl)-L-aspartic acid (PALA) are disclosed. The present methods are well suited for preparation of these products in large amounts. A particular aspect of these methods includes a water-ethanol washing procedure for reducing impurities, including acetic acid, sodium acetate and ethanol, to an acceptable level.
    Type: Grant
    Filed: August 10, 1978
    Date of Patent: May 15, 1979
    Inventors: Jack L. Parsons, Henryk Dubicki