Abstract: The invention discloses a method and spectral-imaging device for optochemical sensing with plasmon-modified multiband fluorescence polarization and with plasmon-modified polarization phase shift changes of a light beam reflected and/or passed through a total internal reflection conducting structure. The optochemical sensing is performed for molecules placed nearby the conducting structure and being excited by surface plasmon resonance (SPR) to lower excited state (LES) and/or to higher excited states (HES). The invention also describes the spectral imaging device with an improved sensitivity of several orders of magnitude. The disclosed method and imaging device may find applications in clinical diagnostics, pharmaceutical screening, biomedical research, biochemical-warfare detection and other diagnostic techniques. The device can be used in bio-chip and micro-array technologies, flowcytometer, fiber optic and other types of diagnostic devices.

Abstract: A device is provided, in direct skin contact, surrounding an injured area for the light and heat treatment, reduction of joint inflammation, edema and excitation of neural and muscular stimulation associated with human and mammal tissues. This therapeutic light and heat source includes multiple tiers or layers, e.g., three or four layers and a multiplicity of light emitting diodes (LED's) found in the ranges of 250 nm to 20,000 nm and fiber optic connections. A neoprene type material or other non-allergenic material will be used to set the LED's and fiber optics in layers consisting of contact with the skin to a few centimeters from the skin tissue. (Distance between the layers of LED's will vary from contact or near contact with devices to several millimeters of separation.) Each LED array will be independently controlled allowing for optimal modulation of light frequencies and wavelengths.

Abstract: Methods and applications of surface plasmon resonance-enhanced antibacterial, anti-adhere, adhere, catalytic, hydrophilic, hydrophobic, spectral change, biological and chemical decomposition properties of materials with embedded nanoparticles are disclosed. A method of the nonlinear generation of surface plasmon resonance enables the use of light with wavelengths from X-Ray to IR to enhance properties of materials by several orders of magnitude. The nanoparticle size is crucial for the enhancement and their size is considered to be in the proposed methods and applications within a range of 0.1 nm to 200,000 nm. The nanoparticles preferably are made of noble metals and/or semiconductor oxides.

Abstract: This invention describes a method of use surface plasmon of nanoparticles to enhance CRT, LCD, OLED, Plasma and other display technologies. The plasmon-enhanced nanoparticles interacting with nearby luminophores, liquid crystals or other materials improve in display technologies brightness, contrast, and longevity of luminophores; make faster response time and better direction emission display. The plasmon-enhanced nanoparticles like quantum dots can be also used directly as a luminophores in quantum display technologies.

Abstract: The methods and applications of a surface plasmon resonance-enhanced marking technique are disclosed. The technique uses surface plasmon resonance (SPR) excited nanoparticles and a surface plasmon resonance source in nonlinear interactions with nearby chemical substances and medium for marking purposes. The SPR-enhanced absorption and fluorescence rates of chemical substances or medium and nonlinearity of SPR interactions with chemical substances or medium make the proposed method suitable for marking fragile materials including biomaterials, such as writing on thin plastic foils or DNA-protein crosslinking. The marking method can also be applied to a three-dimensional recording and read out information system with subwavelength resolutions, coding information of secrete documents, drug delivery, tissue surgery, tattoo writing or removal, photodynamic therapy, cosmetic and dermatological treatment.

Abstract: Acoustic-optical therapy devices and methods for therapeutical purposes are disclosed in this invention. The devices provide a combination of ultrasound energy and optical pulsed energy exposed to human and animal body at frequencies of ultrasound and optical pulses within the range of 1 Hz to 1 GHz and at wavelengths from 0.2 micrometer to 20 micrometers. Both ultrasound energy and pulsed light radiation are delivered in effective combinations to maximize the therapy. Because of different interaction nature of ultrasound and light with body, the new invented devices will provide much more effective and specific body treatment.

Abstract: Methods and compositions of a surface plasmon resonance enhanced body treatment and bacterial management are described. Under the enhanced interaction of surface plasmon resonance and a metal nanoparticle with a nearby biological substance, the biological substance is biochemically and/or biophysically modified or destroyed. The methods and compositions use electromagnetic radiation at a single wavelength or plurality wavelengths of 200 nm to 10,000 nm, metal nanoparticles in size 1 nm to 20,000 nm, inorganic or organic chemical agents, and one-photon or multi-photon modes of electromagnetic radiation for surface plasmon resonance generation.

Abstract: This invention relates to methods and compositions of an optochemical absorption and fluorescence sensing of materials for molecular identification and measuring the concentration of one or more analytes in the sample. The methods and compositions of an enhanced absorption and fluorescence multibands of a molecule by surface plasmon resonance of metal nanoparticles are described. The invention expands the analytical capacity of conventional, single-band absorption and fluorescence spectroscopy and sensing through implementation of the method of enhanced multi-band absorption and fluorescence of higher excited states (HES) and lowest excited state (LES) of the same molecule when the molecule is in close proximity to metal nanoparticles. The method provides a band-selective enhancement of a low quantum yield emission of HES fluorescence that leads to easy-to-detect multi-band fluorescence.

Abstract: A device is provided, in direct skin contact, surrounding an injured area for the treatment, reduction of joint inflammation, edema and excitation of neural and muscular stimulation associated with human and mammal tissues. This therapeutic light source includes a multiplicity of light emitting diodes (LED's) found in the ranges of 350 nm to 1000+ nm and fiber optic connections. A neoprene type material or other non-allergenic material will be used to set the LED's and fiber optics in layers consisting of contact with the skin to few centimeters from the skin tissue. Distance will vary from contact or near contact with devices to several millimeters of separation. Each LED array will be independently controlled allowing for optimal modulation of light frequencies and wavelengths. Technology will be integrated allowing for biomedical feedback of tissue temperature and other statistical information.

Abstract: A method of measuring an analyte present in animal (e.g., human) tissue or fluids such as blood or plasma. The analyte is multi-photon excitable (e.g., two-photon excitable) at a first wavelength at which the animal tissue is substantially non-absorbing. The analyte fluoresces at a second wavelength upon being excited at the first wavelength. The animal tissue is irradiated with radiation at the first wavelength so as to excite the analyte through absorption by the analyte of two or more photons of the radiation at the first wavelength. Excitation of the analyte results in a fluorescent emission from the analyte of radiation at the second wavelength. The emission at the second wavelength is detected, and the concentration of analyte determined based on the detected emission.