Patents by Inventor Henryk Zaleski
Henryk Zaleski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11307172Abstract: An ion detection assembly is described that includes a drift chamber, an inlet assembly, and a collector assembly. The drift chamber is formed of substantially non-conductive material and/or semi-conductive material. A patterned resistive trace is deposited on one or more of an interior surface or an exterior surface of the drift chamber. The patterned resistive trace is configured to connect to a source of electrical energy. The inlet assembly and the collector assembly are in fluid communication with the drift chamber. The inlet assembly includes an inlet for receiving a sample, a reaction region for ionizing the sample, and a gate for controlling entrance of the ionized sample to the drift chamber. The collector assembly includes a collector plate for collecting the ionized sample after the ionized sample passes through the drift chamber.Type: GrantFiled: October 25, 2018Date of Patent: April 19, 2022Assignee: Smiths Detection Montreal, Inc.Inventors: Bohdan Atamanchuk, Volodimir Bondarenko, Vlad Sergeyev, Henryk Zaleski, Daniel Levin, Mark Piniarski, Igor Kubelik, Qunzhou Bian, Simon Feldberg, Douglas J. Green, Brian Boso, Atin J. Patel
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Publication number: 20200144043Abstract: An ion transfer system includes an ion source coupled to an ion inlet; an ion transfer tube assembly including a concentric ion transfer tube with a porous material that is permeable to a gas, the concentric ion transfer tube coupled to the ion inlet and the ion source, where a first gas that includes an ion stream flows through the concentric ion transfer tube; and a concentric gas tube, the concentric ion transfer tube disposed within the concentric gas tube, where a second gas flows between the concentric ion transfer tube and the concentric gas tube; an ion detection device coupled to a capillary tube that is coupled to the concentric ion transfer tube, where the capillary tube transports the ion stream to the ion detection device; and a pump coupled to at least one of the concentric ion transfer tube or the concentric gas tube.Type: ApplicationFiled: June 30, 2017Publication date: May 7, 2020Inventors: Henryk Zaleski, Reno Debono
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Patent number: 10338027Abstract: Systems and methods disclosed provide for methods of managing polarity switching in an ion mobility spectrometer, and provide for management of the repelling grid voltage, the gating grid voltage, and the fixed grid voltage during polarity switching. Systems and methods also provide for the management of the effect of dielectric relaxation in an insulator proximal to the collector, and provide for a preamplifier coupled to the collector including a switch, and a method of managing the collector output including the switch. Systems and methods consistent with the current disclosure further provide for a method of normalizing ion mobility data by determining fitting coefficients associated with a plurality of measurement data sets, and subtracting the curves determined by the fitting coefficients from the data acquired by the ion mobility spectrometer.Type: GrantFiled: June 28, 2017Date of Patent: July 2, 2019Assignee: Smiths Detection Montreal Inc.Inventors: Henryk Zaleski, Mark Piniarski, Simon Feldberg, Jeff Anderson, Oleg Samarin
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Publication number: 20190128844Abstract: An ion detection assembly is described that includes a drift chamber, an inlet assembly, and a collector assembly. The drift chamber is formed of substantially non-conductive material and/or semi-conductive material. A patterned resistive trace is deposited on one or more of an interior surface or an exterior surface of the drift chamber. The patterned resistive trace is configured to connect to a source of electrical energy. The inlet assembly and the collector assembly are in fluid communication with the drift chamber. The inlet assembly includes an inlet for receiving a sample, a reaction region for ionizing the sample, and a gate for controlling entrance of the ionized sample to the drift chamber. The collector assembly includes a collector plate for collecting the ionized sample after the ionized sample passes through the drift chamber.Type: ApplicationFiled: October 25, 2018Publication date: May 2, 2019Inventors: Bohdan Atamanchuk, Volodimir Bondarenko, Vlad Sergeyev, Henryk Zaleski, Daniel Levin, Mark Piniarski, Igor Kubelik, Qunzhou Bian, Simon Feldberg, Douglas J. Green, Brian Boso, Atin J. Patel
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Patent number: 10139366Abstract: An ion detection assembly is described that includes a drift chamber, an inlet assembly, and a collector assembly. The drift chamber is formed of substantially non-conductive material and/or semi-conductive material. A patterned resistive trace is deposited on one or more of an interior surface or an exterior surface of the drift chamber. The patterned resistive trace is configured to connect to a source of electrical energy. The inlet assembly and the collector assembly are in fluid communication with the drift chamber. The inlet assembly includes an inlet for receiving a sample, a reaction region for ionizing the sample, and a gate for controlling entrance of the ionized sample to the drift chamber. The collector assembly includes a collector plate for collecting the ionized sample after the ionized sample passes through the drift chamber.Type: GrantFiled: March 18, 2014Date of Patent: November 27, 2018Assignee: SMITHS DETECTION MONTREAL INC.Inventors: Bohdan Atamanchuk, Volodimir Bondarenko, Vlad Sergeyev, Henryk Zaleski, Daniel Levin, Mark Piniarski, Igor Kubelik, Qunzhou Bian, Simon Feldberg, Douglas J. Green, Brian Boso, Atin J. Patel
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Patent number: 9837257Abstract: A corona ionization source assembly and fabrication methods are described that include a fine wire including a wire core including a first material, and a wire coating including a second material, where the wire coating surrounds a portion of the wire core, and the diameter of the wire coating is greater than the diameter of the wire core. Additionally, the fine wire may be coupled to a mounting post. In an implementation, a process for fabricating the corona ionization source assembly that employs the techniques of the present disclosure includes forming a wire core, forming a wire coating that surrounds the wire core, forming a mask layer on at least a portion of the wire coating, etching the wire coating, and removing the mask layer from the wire coating.Type: GrantFiled: June 19, 2014Date of Patent: December 5, 2017Assignee: Smiths Detection Montreal Inc.Inventor: Henryk Zaleski
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Publication number: 20170299551Abstract: Systems and methods disclosed provide for methods of managing polarity switching in an ion mobility spectrometer, and provide for management of the repelling grid voltage, the gating grid voltage, and the fixed grid voltage during polarity switching. Systems and methods also provide for the management of the effect of dielectric relaxation in an insulator proximal to the collector, and provide for a preamplifier coupled to the collector including a switch, and a method of managing the collector output including the switch. Systems and methods consistent with the current disclosure further provide for a method of normalizing ion mobility data by determining fitting coefficients associated with a plurality of measurement data sets, and subtracting the curves determined by the fitting coefficients from the data acquired by the ion mobility spectrometer.Type: ApplicationFiled: June 28, 2017Publication date: October 19, 2017Inventors: Henryk Zaleski, Mark Piniarski, Simon Feldberg, Jeff Anderson, Oleg Samarin
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Patent number: 9786477Abstract: An ion transfer system includes an ion source coupled to an ion inlet; an ion transfer tube assembly including a concentric ion transfer tube with a porous material that is permeable to a gas, the concentric ion transfer tube coupled to the ion inlet and the ion source, where a first gas that includes an ion stream flows through the concentric ion transfer tube; and a concentric gas tube, the concentric ion transfer tube disposed within the concentric gas tube, where a second gas flows between the concentric ion transfer tube and the concentric gas tube; an ion detection device coupled to a capillary tube that is coupled to the concentric ion transfer tube, where the capillary tube transports the ion stream to the ion detection device; and a pump coupled to at least one of the concentric ion transfer tube or the concentric gas tube.Type: GrantFiled: June 30, 2016Date of Patent: October 10, 2017Assignee: Smiths Detection Inc.Inventors: Henryk Zaleski, Reno DeBono
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Patent number: 9778224Abstract: An ionization device includes a first electrode comprising a conductive member coated with a dielectric layer. The ionization device also includes a spine extending adjacent to and at least partially along the first electrode. The ionization device further includes a second electrode comprising conductive segments disposed adjacent the first electrode. Each one of the conductive segments contacts the spine at a respective contact location. The dielectric layer of the first electrode separates the conductive member of the first electrode from the spine and the second electrode. The ionization device is configured to create plasma generating locations corresponding to respective crossings of the first electrode and the second electrode.Type: GrantFiled: November 26, 2014Date of Patent: October 3, 2017Assignee: Smiths Detection Montreal Inc.Inventors: Igor Kubelik, Simon Feldberg, Bohdan Atamanchuk, Mark Piniarski, Mark Lekhter, Daniel Levin, Vlad Sergeyev, Henryk Zaleski
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Patent number: 9709530Abstract: Systems and methods disclosed provide for methods of managing polarity switching in an ion mobility spectrometer, and provide for management of the repelling grid voltage, the gating grid voltage, and the fixed grid voltage during polarity switching. Systems and methods also provide for the management of the effect of dielectric relaxation in an insulator proximal to the collector, and provide for a preamplifier coupled to the collector including a switch, and a method of managing the collector output including the switch. Systems and methods consistent with the current disclosure further provide for a method of normalizing ion mobility data by determining fitting coefficients associated with a plurality of measurement data sets, and subtracting the curves determined by the fitting coefficients from the data acquired by the ion mobility spectrometer.Type: GrantFiled: February 3, 2016Date of Patent: July 18, 2017Assignee: SMITHS DETECTION MONTREAL INC.Inventors: Henryk Zaleski, Mark Piniarski, Simon Feldberg, Jeff Anderson, Oleg Samarin
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Publication number: 20170023525Abstract: An ionization device includes a first electrode comprising a conductive member coated with a dielectric layer. The ionization device also includes a spine extending adjacent to and at least partially along the first electrode. The ionization device further includes a second electrode comprising conductive segments disposed adjacent the first electrode. Each one of the conductive segments contacts the spine at a respective contact location. The dielectric layer of the first electrode separates the conductive member of the first electrode from the spine and the second electrode. The ionization device is configured to create plasma generating locations corresponding to respective crossings of the first electrode and the second electrode.Type: ApplicationFiled: November 26, 2014Publication date: January 26, 2017Inventors: Igor Kubelik, Simon Feldberg, Bohdan Atamanchuk, Mark Piniarski, Mark Lekhter, Daniel Levin, Vlad Sergeyev, Henryk Zaleski
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Publication number: 20160231276Abstract: Systems and methods disclosed provide for methods of managing polarity switching in an ion mobility spectrometer, and provide for management of the repelling grid voltage, the gating grid voltage, and the fixed grid voltage during polarity switching. Systems and methods also provide for the management of the effect of dielectric relaxation in an insulator proximal to the collector, and provide for a preamplifier coupled to the collector including a switch, and a method of managing the collector output including the switch. Systems and methods consistent with the current disclosure further provide for a method of normalizing ion mobility data by determining fitting coefficients associated with a plurality of measurement data sets, and subtracting the curves determined by the fitting coefficients from the data acquired by the ion mobility spectrometer.Type: ApplicationFiled: February 3, 2016Publication date: August 11, 2016Inventors: Henryk Zaleski, Mark Piniarski, Simon Feldberg, Jeff Anderson, Oleg Samarin
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Publication number: 20160155623Abstract: A corona ionization source assembly and fabrication methods are described that include a fine wire including a wire core including a first material, and a wire coating including a second material, where the wire coating surrounds a portion of the wire core, and the diameter of the wire coating is greater than the diameter of the wire core. Additionally, the fine wire may be coupled to a mounting post. In an implementation, a process for fabricating the corona ionization source assembly that employs the techniques of the present disclosure includes forming a wire core, forming a wire coating that surrounds the wire core, forming a mask layer on at least a portion of the wire coating, etching the wire coating, and removing the mask layer from the wire coating.Type: ApplicationFiled: June 19, 2014Publication date: June 2, 2016Inventor: Henryk Zaleski
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Patent number: 9287102Abstract: Systems and methods disclosed provide for methods of managing polarity switching in an ion mobility spectrometer, and provide for management of the repelling grid voltage, the gating grid voltage, and the fixed grid voltage during polarity switching. Systems and methods also provide for the management of the effect of dielectric relaxation in an insulator proximal to the collector, and provide for a preamplifier coupled to the collector including a switch, and a method of managing the collector output including the switch. Systems and methods consistent with the current disclosure further provide for a method of normalizing ion mobility data by determining fitting coefficients associated with a plurality of measurement data sets, and subtracting the curves determined by the fitting coefficients from the data acquired by the ion mobility spectrometer.Type: GrantFiled: October 27, 2011Date of Patent: March 15, 2016Assignee: SMITHS DETECTION MONTREAL INC.Inventors: Henryk Zaleski, Mark Piniarski, Simon Feldberg, Jeff Anderson, Oleg Samarin
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Patent number: 8901489Abstract: Looped ionization sources for ion mobility spectrometers are described. The ionization sources can be used to ionize molecules from a sample of interest in order to identify the molecules based on the ions. In an implementation, an electrical ionization source includes a wire that is looped between electrical contacts. The wire is used to form a corona responsive to application of voltage between the wire and the walls of an ionization chamber. The corona can form when a sufficient voltage is applied between the wire and the walls. A difference in electrical potential between the wire and a wall forming an ionization chamber, in which wire is contained, can be used to draw the ions away from the wire. In embodiments, the wire can be heated to reduce the voltage used to strike the corona. The ions, subsequently, may ionize the molecules from the sample of interest. The looped corona source can also be used in mass spectrometers (MS).Type: GrantFiled: June 15, 2012Date of Patent: December 2, 2014Assignee: Smiths Detection Montreal Inc.Inventors: Daniel Levin, Vlad Sergeyev, Volodimir Bondarenko, Bohdan Atamanchuk, Qunzhou Bian, Henryk Zaleski, Mark Piniarski, Simon Feldberg, Ronald Jackson
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Publication number: 20140264021Abstract: An ion detection assembly is described that includes a drift chamber, an inlet assembly, and a collector assembly. The drift chamber is formed of substantially non-conductive material and/or semi-conductive material. A patterned resistive trace is deposited on one or more of an interior surface or an exterior surface of the drift chamber. The patterned resistive trace is configured to connect to a source of electrical energy. The inlet assembly and the collector assembly are in fluid communication with the drift chamber. The inlet assembly includes an inlet for receiving a sample, a reaction region for ionizing the sample, and a gate for controlling entrance of the ionized sample to the drift chamber. The collector assembly includes a collector plate for collecting the ionized sample after the ionized sample passes through the drift chamber.Type: ApplicationFiled: March 18, 2014Publication date: September 18, 2014Applicant: Smiths Detection Montreal Inc.Inventors: Bohdan Atamanchuk, Volodimir Bondarenko, Vlad Sergeyev, Henryk Zaleski, Daniel Levin, Mark Piniarski, Igor Kubelik, Qunzhou Bian, Simon Feldberg, Douglas J. Green, Brian Boso, Atin J. Patel
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Publication number: 20140246581Abstract: Looped ionization sources for ion mobility spectrometers are described. The ionization sources can be used to ionize molecules from a sample of interest in order to identify the molecules based on the ions. In an implementation, an electrical ionization source includes a wire that is looped between electrical contacts. The wire is used to form a corona responsive to application of voltage between the wire and the walls of an ionization chamber. The corona can form when a sufficient voltage is applied between the wire and the walls. A difference in electrical potential between the wire and a wall forming an ionization chamber, in which wire is contained, can be used to draw the ions away from the wire. In embodiments, the wire can be heated to reduce the voltage used to strike the corona. The ions, subsequently, may ionize the molecules from the sample of interest. The looped corona source can also be used in mass spectrometers (MS).Type: ApplicationFiled: June 15, 2012Publication date: September 4, 2014Applicant: SMITHS DETECTION MONTREAL INC.Inventors: Daniel Levin, Vlad Sergeyev, Volodimir Bondarenko, Bohdan Atamanchuk, Qunzhou Bian, Henryk Zaleski, Mark Piniarski, Simon Feldberg, Ronald Jackson
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Publication number: 20130284914Abstract: Systems and methods disclosed provide for methods of managing polarity switching in an ion mobility spectrometer, and provide for management of the repelling grid voltage, the gating grid voltage, and the fixed grid voltage during polarity switching. Systems and methods also provide for the management of the effect of dielectric relaxation in an insulator proximal to the collector, and provide for a preamplifier coupled to the collector including a switch, and a method of managing the collector output including the switch. Systems and methods consistent with the current disclosure further provide for a method of normalizing ion mobility data by determining fitting coefficients associated with a plurality of measurement data sets, and subtracting the curves determined by the fitting coefficients from the data acquired by the ion mobility spectrometer.Type: ApplicationFiled: October 27, 2011Publication date: October 31, 2013Applicant: SMITHS DETECTION MONTREALInventors: Henryk Zaleski, Mark Piniarski, Simon Feldberg, Jeff Anderson, Oleg Samarin
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Patent number: 6760668Abstract: In order to align DNA sequence data traces, an experimental data trace representing the positions of a first species of base within a target polynucleotide and a reference data trace representing the positions of a second species of base (which may be the same as or different from the first species) within a reference polynucleotide are obtained by separating appropriate sequencing fragments generated from the target and reference polynucleotides on an electrophoresis gel. For each reference data trace, a plurality of peaks corresponding to fragments having a size in the range of 40 to 1200 bases are selected. A base number is assigned to each of the selected peaks in the reference data trace, and a numerical “peak file” is created with information about the peak number and migration time (or distance).Type: GrantFiled: March 24, 2000Date of Patent: July 6, 2004Assignee: Bayer HealthCare LLCInventors: Alexandre Izmailov, Henryk Zaleski, Stephen Darasch
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Patent number: 6054036Abstract: Gel holders for electrophoresis gels are made using clad fibers, particularly glass fibers as spacers between substrates. A plurality of fibers with a high-melting interior core and a low-melting external cladding are placed between a first planar substrate and a second planar substrate. The fibers are heated to a temperature sufficient to at least soften the exterior cladding of the fibers without softening the interior core of the fibers, and then cooled while they are in contact with the first and second substrates to solidify the exterior cladding. This adheres the fibers to the first and second substrates, and forms a gel chamber between said first and second substrates. The gel chamber has a thickness defined by interior core of the fibers. The fibers may be heated before or after the second substrate is placed over the top of the fibers. The gel holders thus formed may be filled immediately with a gel forming solution such as a polyacrylamide, or they may be stored indefinitely and used as needed.Type: GrantFiled: December 31, 1998Date of Patent: April 25, 2000Assignee: Visible Genetics Inc.Inventors: Alexandre M. Izmailov, Paul Waterhouse, Henryk Zaleski