Patents by Inventor Heong Wai Tse

Heong Wai Tse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phenanthryl piperazinyl dicarboxylic acids as selective NMDA receptor modulating agents
    Patent number: 6916816
    Abstract: Disclosed are compounds of formula (I) wherein: L is (a) optionally substituted by replacement of one or more of the hydrogen atoms on the phenanthrene ring system by one or more groups other than hydrogen; A is CH2, SO2 or C?O; X is CO2H, PO3H2, PO2H2, PO2HR5, PO2HOR5, SO3H, SO2H, or tetrazole; and R1, R2, R3, R4 and R5 are independently selected from H, alkyl, alkenyl, alkynyl, aryl and aralkyl; or a pharmaceutically acceptable acid salt or base addition salt or an in vivo hydrolysable ester or amide thereof.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: July 12, 2005
    Assignees: The Board of Regents of the University of Nebraska, The University of Bristol
    Inventors: Daniel T. Monaghan, David E. Jane, Heong Wai Tse
  • Phenanthryl piperazinyl dicarboxylic acids as selective nmda receptor modulating agents
    Publication number: 20030078237
    Abstract: Disclosed are compounds of formula (I) wherein: L is (a) optionally substituted by replacement of one or more of the hydrogen atoms on the phenanthrene ring system by one or more groups other than hydrogen; A is CH2, SO2 or C═O; X is CO2H, PO3H2, PO2H2, PO2HR5, PO2HOR5, SO3H, SO2H, or tetrazole; and R1, R2, R3, R4 and R5 are independently selected from H, alkyl, alkenyl, alkynyl, aryl and aralkyl; or a pharmaceutically acceptable acid salt or base addition salt or an in vivo hydrolysable ester or amide thereof. Compounds of formula (I) are selective NMDA receptor modulating agents and, therefore, may be used to advantage in vitro in neuroassays and in vivo in the treatment of disorders of the CNS.
    Type: Application
    Filed: September 3, 2002
    Publication date: April 24, 2003
    Inventors: Daniel T Monaghan, David E Jane, Heong Wai Tse