Patents by Inventor Hephzibah Sivaraman

Hephzibah Sivaraman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for production of large amount of penicillin V acylase
    Publication number: 20050142652
    Abstract: The present invention relates to a recombinant plasmid of FIG. 1, wherein (1) is pET-26b(+) cloning/expression region with SEQ ID No. 1 cloned between BamH I site 198 and Nde I site 288, (2) is lac I coding sequence, (3) is pBR322 origin, (4) is Kan coding sequence, and (5) is f1 origin; a recombinant E. Coli strain PTA 2456; and lastly, a process for the production of large amount of Penicillin V acylase using recombinant E. Coli strain PTA 2456.
    Type: Application
    Filed: March 30, 2004
    Publication date: June 30, 2005
    Inventors: Hephzibah Sivaraman, Archana Pundle, Cheravakkattu Suresh, George Dodson, James Brannigan
  • Garlic alliinase covalently bound to carrier for continuous production of allician
    Patent number: 6689588
    Abstract: Immobilized garlic alliinase wherein the alliinase is chemically, physically or biologically immobilized, is useful in a method for continuous production of allicin. The method comprises adding a solution of alliin as substrate to a column containing the immobilized garlic alliinase and collecting pure allicin in the effluent. The pure allicin is intended for use as food additive or for the preparation of pharmaceutical compositions for the treatment of viral, bacterial, fungal and parasitic infections, high levels of cholesterol and blood lipids, high blood pressure and thrombosis.
    Type: Grant
    Filed: September 12, 2000
    Date of Patent: February 10, 2004
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Mirelman, Meir Wilchek, Talia Miron, Aharon Rabinkov, Hephzibah Sivaraman