Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Abstract: The present invention relates to a deep rock in situ environment reconstruction and integrated three-dimensional mechanical-thermo-acousto-seismic-flow testing method, which comprises: preparing a cubic sample; placing the cubic sample in a sample holder; extending the 6 indenters to butt with the sample holder; butting 6 butting indenters with the 6 indenters; butting each of 6 hydraulic actuators with one of the butting indenters, performing stress loading on the cubic sample by the hydraulic actuator, filling a fluid medium into the cubic sample by a percolation medium channel, and dynamically measuring related parameters. The present application can achieve three-way multi-parameter synchronous monitoring and acquisition of deformation, acoustic emission, ultrasonic wave, temperature field, percolation field and heat flow field.

Abstract: The present invention relates to a rock physico-mechanical testing chamber and a three-dimensional multi-field information perception cabin in simulated environments of deep earth, deep space, and deep sea. The testing chamber comprises a cabin body and 6 butting indenters; the 6 butting indenters are pairwise located in an X-axis direction, a Y-axis direction and a Z-axis direction; the 6 butting indenters are respectively mounted in through holes on six faces of the cabin body, inner ends of the butting indenters extend into the cabin body, outer ends of the butting indenters are exposed out of the cabin body, and the butting indenters can axially move relative to the cabin body. The present application can be used to achieve the reservoir rock mechanical behavior testing in real time under high and low environments.

Abstract: This application provides a vehicle and a power battery heating apparatus and method thereof. In the method, when a current temperature value of a power battery is lower than a preset temperature value, and a heating condition of the power battery meets a preset condition, a three-phase inverter is controlled to cause a three-phase alternating current motor to generate heat to heat a coolant flowing through the power battery. A preset quadrature-axis current and a corresponding preset direct-axis current are obtained to control the three-phase inverter to adjust a phase current of the three-phase alternating current motor in the heating process, so that electromagnetic torque with a small torque value is outputted at a motor shaft. The electromagnetic torque causes the motor output shaft to output a pre-tightening force to the transmission mechanism, thereby eliminating an engagement gap and effectively avoiding jitters of the vehicle.

Abstract: The present invention relates to a deep rock in situ environment reconstruction and integrated three-dimensional mechanical-thermo-acousto-seismic-flow testing method, which comprises: preparing a cubic sample; placing the cubic sample in a sample holder; extending the 6 indenters to butt with the sample holder; butting 6 butting indenters with the 6 indenters; butting each of 6 hydraulic actuators with one of the butting indenters, performing stress loading on the cubic sample by the hydraulic actuator, filling a fluid medium into the cubic sample by a percolation medium channel, and dynamically measuring related parameters. The present application can achieve three-way multi-parameter synchronous monitoring and acquisition of deformation, acoustic emission, ultrasonic wave, temperature field, percolation field and heat flow field.

Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Abstract: A real-time temperature-pressure detection and rapid processing system for a calibration platform, comprises an inner return pipe, and a water supply pipe is provided therein with an inner water supply pipe. An outer wall of the inner water supply pipe is connected with an inner wall of the water supply pipe through multiple springs. An outer wall of the inner return pipe is connected with an inner wall of a return pipe through multiple springs. The return pipe and the water supply pipe are made of a thermosetting polymer material. The multiple springs, the inner water supply pipe, and the inner return pipe are covered with a heat conducting material. The system further includes a temperature-pressure detection assembly. The assembly includes multiple infrared sensors arranged at two sides of the return pipe and the water supply pipe, a booster pump, a heater, and infrared sensors connected with a control unit.

Abstract: An assembly method for a deep in-situ high-fidelity coring calibration platform includes the following steps: S1: fixing a core bin assembly subsystem on a preset ground foundation and fixing a simulator of a core bin on a mounting base plate of the core bin assembly subsystem; S2: driving a cylinder and driving the mounting base plate to move to a preset position; S3: driving a servo motor and controlling two clips to move close to each other; S4: fixing a drill pipe bin assembly subsystem on the ground foundation; S5: assembling multiple sections of a drill pipe bin in turn; aligning and connecting a bottom of the drill pipe bin to the simulator, and aligning and communicating the top of the drill pipe bin with the lower part of an adaptive drill pipe guide structure; and S6: driving the adaptive drill pipe guide structure to perform accurate positioning.

Abstract: The application relates to a rock physico-mechanical testing system in simulated environments of deep earth, deep space, and deep sea, which comprises a three-axis six-direction loading system and an experimental cabin, wherein the three-axis six-direction loading system comprises a loading frame and 6 actuators; an experimental cabin accommodation chamber is arranged in the loading frame, the experimental cabin accommodation chamber is provided with 6 loading ports, and six actuators are each adapted to one of the loading ports; the experimental cabin comprises a cabin body and 6 butting indenters, wherein the 6 butting indenters are respectively arranged in through holes of the cabin body in six directions and can axially move relative to the cabin body; and front ends of the six actuators are each operatively butted with a rear end of one of the butting indenters. The application can be used to achieve the reservoir rock mechanical behavior testing.

Abstract: A method for robotic adaptive production includes modifying program instructions online while performing production activities in response to detecting a change in the production environment. A robotic adaptive production method includes modifying program instructions online while performing production activities to minimize a production task cycle time or improve a production task quality. A robotic adaptive production method includes estimating a relationship between a control parameter and a sensor input; and modifying the control parameter online to achieve an updated parameter based on the estimating. A robotic adaptive production method includes receiving sensor input relating to robotic performance during the performance of production tasks and online optimizing a process parameter based on robotic performance during the performance of the production tasks.

Abstract: A method for process parameter optimization in a robotic manufacturing process includes identifying, in two or more successive iterations, a system model for the robotic manufacturing process. Manufacturing process parameters are optimized based on the model identified. The process may be a robotic assembly process.

Abstract: A method for robotic adaptive production includes modifying program instructions online while performing production activities in response to detecting a change in the production environment. A robotic adaptive production method includes modifying program instructions online while performing production activities to minimize a production task cycle time or improve a production task quality. A robotic adaptive production method includes estimating a relationship between a control parameter and a sensor input; and modifying the control parameter online to achieve an updated parameter based on the estimating. A robotic adaptive production method includes receiving sensor input relating to robotic performance during the performance of production tasks and online optimizing a process parameter based on robotic performance during the performance of the production tasks.

Abstract: A method for process parameter optimization in a robotic manufacturing process includes identifying, in two or more successive iterations, a system model for the robotic manufacturing process. Manufacturing process parameters are optimized based on the model identified. The process may be a robotic assembly process.

Abstract: An industrial robot is used to assemble a part to a predetermined location on a randomly moving workpiece. The workpiece may be an automobile on an assembly line and the part may be a wheel (a tire mounted on a rim) to be assembled on one of the wheel hubs of the automobile. The robot has mounted on it a camera, a force sensor and a gripper to grip the part. After the robot grips the part, signals from both the force sensor and vision are used by a computing device to move the robot to a position where the robot can assemble the part to the predetermined location on the workpiece. The computing device can be the robot controller or a separate device such as a PC that is connected to the controller.

Abstract: A teleoperated robot system has a watchdog to determine if the rate of data transmission from a computing device such as a robot controller located in the station used by the operator of the teleoperated robot to the remotely located industrial robot has fallen below a minimum data rate or the time for transmission of data has exceeded a maximum time. Upon the occurrence of either or both of the foregoing, one or more types of corrective action are undertaken to bring the teleoperated robot and the processes performed by the robot.