Patents by Inventor Heping Yang
Heping Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240102042Abstract: The invention provides novel recombinant DNA molecules, compositions, and methods for selectively regulating the expression of a transcribable polynucleotide molecule or recombinant protein in a male reproductive tissue of a transgenic plant. The invention also provides transgenic plants, plant cells, plant parts, seeds, and commodity products comprising such DNA molecules and compositions.Type: ApplicationFiled: November 8, 2023Publication date: March 28, 2024Inventors: Jintai Huang, Youlin Qi, Heping Yang, Yuanji Zhang
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Patent number: 11866721Abstract: The invention provides novel recombinant DNA molecules, compositions, and methods for selectively regulating the expression of a transcribable polynucleotide molecule or recombinant protein in a male reproductive tissue of a transgenic plant. The invention also provides transgenic plants, plant cells, plant parts, seeds, and commodity products comprising such DNA molecules and compositions.Type: GrantFiled: April 9, 2020Date of Patent: January 9, 2024Assignee: MONSANTO TECHNOLOGY LLCInventors: Jintai Huang, Youlin Qi, Heping Yang, Yuanji Zhang
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Publication number: 20230279508Abstract: The invention provides a transgenic corn event ZM_BCS216090, plants, plant cells, seeds, plant parts, progeny plants, and commodity products comprising event ZM_BCS216090. The invention also provides polynucleotides and sequences specific for event ZM_BCS216090 and methods for using plants, plant cells, seeds, plant parts, progeny plants, and commodity products comprising event ZM_BCS216090 and detecting event ZM_BCS216090, or a polynucleotide or DNA sequence specific for event ZM_BCS216090, in a DNA molecule or sample.Type: ApplicationFiled: October 19, 2022Publication date: September 7, 2023Inventors: Lillian Brzostowski, Carrin Carlson, Kelley Gillespie, Tomasz Paciorek, Lyle Ralston, Alexandar Renaud, Heping Yang
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Patent number: 11587994Abstract: A method for manufacturing the pixel definition layer includes forming a photolithographic material film on a substrate; performing a pre-drying treatment, a first exposure treatment, and a development treatment sequentially on the photolithographic material film to form an initial pattern of the pixel definition layer; and performing a second exposure treatment and a curing treatment sequentially on the initial pattern to form a final pattern of the pixel definition layer.Type: GrantFiled: December 18, 2019Date of Patent: February 21, 2023Assignees: CHENGDU BOE OPTOELECTRONICS TECHNOLOGY CO., LTD., BOE TECHNOLOGY GROUP CO., LTD.Inventors: Shitao Zhang, Li Xiong, Cheng Tang, Hao Zhang, Qijun Zhao, Heping Yang, Gaoliang Xue
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Publication number: 20210367012Abstract: A method for manufacturing the pixel definition layer includes forming a photolithographic material film on a substrate; performing a pre-drying treatment, a first exposure treatment, and a development treatment sequentially on the photolithographic material film to form an initial pattern of the pixel definition layer; and performing a second exposure treatment and a curing treatment sequentially on the initial pattern to form a final pattern of the pixel definition layer.Type: ApplicationFiled: December 18, 2019Publication date: November 25, 2021Inventors: Shitao ZHANG, Li XIONG, Cheng TANG, Hao ZHANG, Qijun ZHAO, Heping YANG, Gaoliang XUE
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Publication number: 20210207162Abstract: The invention provides recombinant DNA molecules that are unique to maize event MON87429 and transgenic maize plants, maize plant parts, maize seeds, maize cells, and agricultural products containing maize event MON87429 as well as methods of using and detecting maize event MON87429. Transgenic maize plants containing maize event MON87429 exhibit tolerance to inhibitors of acetyl CoA carboxylase (ACCase) in the aryloxyphenoxy propionate (FOP) group, synthetic auxins, inhibitors of glutamine synthetase, and inhibitors of 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS).Type: ApplicationFiled: January 12, 2021Publication date: July 8, 2021Inventors: Christine M. Ellis, Michael E. Goley, Jintai Huang, Tracy E. Klingaman, Clayton T. Larue, Youlin Qi, Oscar C. Sparks, Brook M. Van Scoyoc, Heping Yang
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Patent number: 10920239Abstract: The invention provides recombinant DNA molecules that are unique to maize event MON87429 and transgenic maize plants, maize plant parts, maize seeds, maize cells, and agricultural products containing maize event MON87429 as well as methods of using and detecting maize event MON87429. Transgenic maize plants containing maize event MON87429 exhibit tolerance to inhibitors of acetyl CoA carboxylase (ACCase) in the aryloxyphenoxy propionate (FOP) group, synthetic auxins, inhibitors of glutamine synthetase, and inhibitors of 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS).Type: GrantFiled: January 28, 2019Date of Patent: February 16, 2021Assignee: Monsanto Technology LLCInventors: Christine M. Ellis, Michael E. Goley, Jintai Huang, Tracy E. Klingaman, Clayton T. Larue, Youlin Qi, Oscar C. Sparks, Brook M. Van Scoyoc, Heping Yang
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Publication number: 20200283790Abstract: The invention provides novel recombinant DNA molecules, compositions, and methods for selectively regulating the expression of a transcribable polynucleotide molecule or recombinant protein in a male reproductive tissue of a transgenic plant. The invention also provides transgenic plants, plant cells, plant parts, seeds, and commodity products comprising such DNA molecules and compositions.Type: ApplicationFiled: April 9, 2020Publication date: September 10, 2020Inventors: Jintai Huang, Youlin Qi, Heping Yang, Yuanji Zhang
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Patent number: 10704057Abstract: The invention provides novel recombinant DNA molecules, compositions, and methods for selectively regulating the expression of a transcribable polynucleotide molecule or recombinant protein in a male reproductive tissue of a transgenic plant. The invention also provides transgenic plants, plant cells, plant parts, seeds, and commodity products comprising such DNA molecules and compositions.Type: GrantFiled: July 14, 2016Date of Patent: July 7, 2020Assignee: Monsanto Technology LLCInventors: Jintai Huang, Youlin Qi, Heping Yang, Yuanji Zhang
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Patent number: 10669252Abstract: Disclosed are a benzazepine derivative, a preparation method, a pharmaceutical composition and the use thereof. A compound as shown in formula (I) of the present invention, and an isomer, a prodrug, a stable isotope derivative or a pharmaceutically acceptable salt thereof have the following structure. The benzazepine derivative of the present invention has a good regulation effect on the TLR family and the related signaling pathway, and in particular, has a good regulation effect on TLR8, can effectively treat, relieve and/or prevent various diseases mediated by TLR family and the TLR-related signaling pathway, and in particular, can effectively treat, relieve and/or prevent various diseases mediated by TLR8, such as cancers, autoimmune diseases, infections, inflammations, transplantation rejections, graft-versus-host diseases, etc.Type: GrantFiled: May 4, 2017Date of Patent: June 2, 2020Assignee: SHANGHAI DE NOVO PHARMATECH CO., LTD.Inventors: Daxin Gao, Yuxun Wang, Shoujun Chen, Heping Yang
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Publication number: 20190241903Abstract: The invention provides recombinant DNA molecules that are unique to maize event MON87429 and transgenic maize plants, maize plant parts, maize seeds, maize cells, and agricultural products containing maize event MON87429 as well as methods of using and detecting maize event MON87429. Transgenic maize plants containing maize event MON87429 exhibit tolerance to inhibitors of acetyl CoA carboxylase (ACCase) in the aryloxyphenoxy propionate (FOP) group, synthetic auxins, inhibitors of glutamine synthetase, and inhibitors of 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS).Type: ApplicationFiled: January 28, 2019Publication date: August 8, 2019Inventors: Christine M. Ellis, Michael E. Goley, Jintai Huang, Tracy E. Klingaman, Clayton T. Larue, Youlin Qi, Oscar C. Sparks, Brook M. Van Scoyoc, Heping Yang
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Publication number: 20190152941Abstract: Disclosed are a benzazepine derivative, a preparation method, a pharmaceutical composition and the use thereof. A compound as shown in formula (I) of the present invention, and an isomer, a prodrug, a stable isotope derivative or a pharmaceutically acceptable salt thereof have the following structure. The benzazepine derivative of the present invention has a good regulation effect on the TLR family and the related signaling pathway, and in particular, has a good regulation effect on TLR8, can effectively treat, relieve and/or prevent various diseases mediated by TLR family and the TLR-related signaling pathway, and in particular, can effectively treat, relieve and/or prevent various diseases mediated by TLR8, such as cancers, autoimmune diseases, infections, inflammations, transplantation rejections, graft-versus-host diseases, etc.Type: ApplicationFiled: May 4, 2017Publication date: May 23, 2019Applicant: SHANGHAI DE NOVO PHARMATECH CO., LTD.Inventors: Daxin GAO, Yuxun WANG, Shoujun CHEN, Heping YANG
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Patent number: 9914724Abstract: This invention relates to a kind of C- aryl glycoside derivatives, its pharmaceutical compositions, preparation methods, and uses thereof. The preparation method comprises: method 1: in a solvent, deprotecting the acetyl protecting groups of compound 1-f in the presence of a base; method 2: 1) compound 2-g reacts with via Mitsunobu reaction; 2) deprotecting the acetyl protecting groups of compound 2-f obtained from step 1; method 3: 1) compound 2-g reacts with via nucleophilic substitution reaction; 2) deprotecting the acetyl protecting groups of compound 3-f obtained from step 1. The pharmaceutical composition comprises a kind of C- aryl glycoside derivatives; it's pharmaceutically acceptable salts and/or prodrugs thereof and excipient thereof. This invention relates to a kind of C- aryl glycoside derivatives, it's pharmaceutically acceptable salts or compositions thereof for preparing a SGLT inhibitor. The C- aryl glycoside derivatives of this invention provides a new direction for SGLT inhibitors.Type: GrantFiled: April 1, 2015Date of Patent: March 13, 2018Assignee: SHANGHAI DE NOVO PHARMATECH CO., LTD.Inventors: Daxin Gao, Heping Yang, Pei Wang
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Publication number: 20170037038Abstract: This invention relates to a kind of C-aryl glycoside derivatives, its pharmaceutical compositions, preparation methods, and uses thereof. The preparation method comprises: method 1: in a solvent, deprotecting the acetyl protecting groups of compound 1-f in the presence of a base; method 2: 1) compound 2-g reacts with via Mitsunobu reaction; 2) deprotecting the acetyl protecting groups of compound 2-f obtained from step 1; method 3: 1) compound 2-g reacts with via nucleophilic substitution reaction; 2) deprotecting the acetyl protecting groups of compound 3-f obtained from step 1. The pharmaceutical composition comprises a kind of C-aryl glycoside derivatives; it's pharmaceutically acceptable salts and/or prodrugs thereof and excipient thereof. This invention further relates to a kind of C-aryl glycoside derivatives, it's pharmaceutically acceptable salts or pharmaceutical compositions thereof for the use in preparation of a SGLT inhibitor.Type: ApplicationFiled: April 1, 2015Publication date: February 9, 2017Applicant: SHANGHAI DE NOVO PHARMATECH CO. LTD.Inventors: Daxin GAO, Heping YANG, Pei WANG
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Publication number: 20170029841Abstract: The invention provides novel recombinant DNA molecules, compositions, and methods for selectively regulating the expression of a transcribable polynucleotide molecule or recombinant protein in a male reproductive tissue of a transgenic plant. The invention also provides transgenic plants, plant cells, plant parts, seeds, and commodity products comprising such DNA molecules and compositions.Type: ApplicationFiled: July 14, 2016Publication date: February 2, 2017Inventors: Jintai Huang, Youlin Qi, Heping Yang, Yuanji Zhang
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Patent number: 9216997Abstract: The present invention relates to a tri-heterocyclic derivatives, preparation process and uses thereof, specifically relates to a tri-heterocyclic derivatives of the formula (I) or a pharmaceutically acceptable salt thereof, preparation process, and further relates to a pharmaceutically acceptable composition comprising compounds of formula (I), or a pharmaceutically acceptable salt thereof, and their pharmaceutical use as inhibitors of kinase.Type: GrantFiled: December 13, 2012Date of Patent: December 22, 2015Assignee: Shanghai De Novo Pharmatech Co Ltd.Inventors: Daxin Gao, Heping Yang, Yajun Yu
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Publication number: 20140329800Abstract: The present invention relates to a tri-heterocyclic derivatives, preparation process and uses thereof, specifically relates to a tri-heterocyclic derivatives of the formula (I) or a pharmaceutically acceptable salt thereof, preparation process, and further relates to a pharmaceutically acceptable composition comprising compounds of formula (I), or a pharmaceutically acceptable salt thereof, and their pharmaceutical use as inhibitors of kinase.Type: ApplicationFiled: December 13, 2012Publication date: November 6, 2014Inventors: Daxin Gao, Heping Yang, Yajun Yu
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Patent number: 8752885Abstract: A releasable tunnel brace for releasably connecting a first side panel to a second panel of a vehicle is disclosed. One or both ends of the brace include a fastener-receiving aperture. The aperture has a round portion and an elongated slot extending therefrom. The round portion can allow the head of a shoulder bolt fastener to pass therethrough. The elongated slot is defined by a pair of opposed walls. The shoulder of the shoulder bolt fastener can pass between the opposed walls. In the event of a side impact, the brace is pushed vehicle inward and the bolt slides through the elongated slot and into the round portion where it is allowed to be released from its attachment position. The brace provides maximum torsion stiffness while withstanding only a minimum amount of lateral force before it releases and thus minimizes local deflection in the event of a side impact.Type: GrantFiled: July 23, 2012Date of Patent: June 17, 2014Assignee: Ford Global Technologies, LLCInventor: Heping Yang
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Publication number: 20140021745Abstract: A releasable tunnel brace for releasably connecting a first side panel to a second panel of a vehicle is disclosed. One or both ends of the brace include a fastener-receiving aperture. The aperture has a round portion and an elongated slot extending therefrom. The round portion can allow the head of a shoulder bolt fastener to pass therethrough. The elongated slot is defined by a pair of opposed walls. The shoulder of the shoulder bolt fastener can pass between the opposed walls. In the event of a side impact, the brace is pushed vehicle inward and the bolt slides through the elongated slot and into the round portion where it is allowed to be released from its attachment position. The brace provides maximum torsion stiffness while withstanding only a minimum amount of lateral force before it releases and thus minimizes local deflection in the event of a side impact.Type: ApplicationFiled: July 23, 2012Publication date: January 23, 2014Applicant: FORD GLOBAL TECHNOLOGIES, LLCInventor: Heping Yang
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Publication number: 20130288895Abstract: Provided are novel compositions for use in herbicide activity. Specifically, methods and compositions that modulate 5-enolpyruvylshikimate-3-phosphate synthase in plant species. The present invention also provides for combinations of compositions and methods that enhance weed control.Type: ApplicationFiled: September 13, 2012Publication date: October 31, 2013Inventors: Daniel Ader, Zhaolong Li, Ronak Hasmukh Shah, Mengbing Tao, Dafu Wang, Heping Yang