Patents by Inventor Hequan Yao

Hequan Yao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic urea compound, and drug composition and application thereof
    Patent number: 11014895
    Abstract: A heterocyclic urea compound, and specifically discloses an indoleamine-2,3-dioxygenase inhibitor of a heterocyclic urea compound, which solves the problems of weak curative effect and larger toxic and side effects of existing immunological therapy drugs. The invention further provides a preparation method for an indoleamine-2,3-dioxygenase inhibitor of a heterocyclic urea compound, and an application of the indoleamine-2,3-dioxygenase inhibitor of a heterocyclic urea compound or a pharmaceutically acceptable salt thereof in preparing drugs for treating or preventing tumors.
    Type: Grant
    Filed: January 1, 2018
    Date of Patent: May 25, 2021
    Assignee: CHINA PHARMACEUTICAL UNIVERSITY
    Inventors: Sheng Jiang, Zhengchao Tu, Haiping Hao, Hequan Yao, Yatao Qiu, Yiwu Yao, Dong Chen
  • HETEROCYCLIC UREA COMPOUND, AND DRUG COMPOSITION AND APPLICATION THEREOF
    Publication number: 20190367465
    Abstract: A heterocyclic urea compound, and specifically discloses an indoleamine-2,3-dioxygenase inhibitor of a heterocyclic urea compound, which solves the problems of weak curative effect and larger toxic and side effects of existing immunological therapy drugs. The invention further provides a preparation method for an indoleamine-2,3-dioxygenase inhibitor of a heterocyclic urea compound, and an application of the indoleamine-2,3-dioxygenase inhibitor of a heterocyclic urea compound or a pharmaceutically acceptable salt thereof in preparing drugs for treating or preventing tumors.
    Type: Application
    Filed: January 1, 2018
    Publication date: December 5, 2019
    Inventors: Sheng JIANG, Zhengchao TU, Haiping HAO, Hequan YAO, Yatao QIU, Yiwu YAO, Dong CHEN
  • Bioluminogenic assay system for measuring beta-lactamase activity
    Patent number: 7867758
    Abstract: A bioluminogenic assay system including: providing a bioluminogenic substrate incorporating a beta-lactam antibiotic, a bioluminescence initiating compound, and a chemical linkage joining the beta-lactam antibiotic to the bioluminescence initiating compound; exposing the bioluminogenic substrate to a beta-lactamase enzyme that catalyzes the release of the bioluminescence initiating compound from the bioluminogenic substrate; co-exposing the bioluminogenic substrate to a bioluminescence indicator reaction that employs the bioluminescence initiating compound as a substrate; and detecting a light from the bioluminescence indicator reaction as a measure of the activity of the beta-lactamase enzyme.
    Type: Grant
    Filed: April 1, 2008
    Date of Patent: January 11, 2011
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jianghong Rao, Min-kyung So, Hequan Yao
  • BIOLUMINOGENIC ASSAY SYSTEM FOR MEASURING BETA-LACTAMASE ACTIVITY
    Publication number: 20090246862
    Abstract: A bioluminogenic assay system including: providing a bioluminogenic substrate incorporating a beta-lactam antibiotic, a bioluminescence initiating compound, and a chemical linkage joining the beta-lactam antibiotic to the bioluminescence initiating compound; exposing the bioluminogenic substrate to a beta-lactamase enzyme that catalyzes the release of the bioluminescence initiating compound from the bioluminogenic substrate; co-exposing the bioluminogenic substrate to a bioluminescence indicator reaction that employs the bioluminescence initiating compound as a substrate; and detecting a light from the bioluminescence indicator reaction as a measure of the activity of the beta-lactamase enzyme.
    Type: Application
    Filed: April 1, 2008
    Publication date: October 1, 2009
    Inventors: Jianghong Rao, Min-kyung So, Hequan Yao