Abstract: The present invention relates to an IgG-binding compound, which more specifically has affinity for human IgGs of ?-type and functional derivatives thereof. More specifically, the compound according to the invention comprises an N,N-alkylated urea moiety located between an aromatic part and another part, which is a linear or cyclic substituted or unsubstituted aliphatic group. The compound binds to a pocket-shaped binding site present on all human IgG ?-Fabs, which site is located between the two domains (CH1 and CL) of its constant part. Accordingly, the compound according to the invention is a ligand for human IgGs of ?-type, and consequently, the invention also relates to a separation matrix for affinity chromatography, which matrix comprises said compound, as well as to other uses of the compound.

Abstract: The invention relates to NMR-based methods comprising hyperpolarised ligands or targets for use in NMR-based assays.

Abstract: The present invention relates to a human IgG binding pocket comprised of a first interacting surface, which originates from an IgG ? light chain, and a second interacting surface, which originates from an IgG heavy chain, which amino acids are strictly conserved between human IgGs of ?-type. The invention also embraces an isolated and purified polypeptide, which comprises said binding pocket. Further, the invention relates to various methods of using the novel binding pocket, such as in screening for identification of chemical entities capable of selective binding thereof, and in other experimental and/or virtual methods for design and/or identification of chemical entities capable of selective binding thereof.

Abstract: The invention relates to NMR-based methods comprising hyperpolarised ligands or targets for use in NMR-based assays.

Abstract: The present invention relates to an IgG-binding compound, which more specifically has affinity for human IgGs of ?-type and functional derivatives thereof. More specifically, the compound according to the invention comprises an N,N-alkylated urea moiety located between an aromatic part and another part, which is a linear or cyclic substituted or unsubstituted aliphatic group. The compound binds to a pocket-shaped binding site present on all human IgG ?-Fabs, which site is located between the two domains (CH1 and CL) of its constant part. Accordingly, the compound according to the invention is a ligand for human IgGs of ?-type, and consequently, the invention also relates to a separation matrix for affinity chromatography, which matrix comprises said compound, as well as to other uses of the compound.

Abstract: The present invention introduces a class of compounds, 2-substituted carbonyl compounds, that are useful as disinfecting agents, and particularly useful in methods for the disinfection of biological fluids. Members of the class of compounds have been found to possess pathogen invactivating properties against a variety of pathogens. The compounds and methods disclosed herein are useful for disinfecting biological fluids such as blood and blood fractions, among others.

Abstract: The present invention introduces a class of compounds, 2-substituted carbonyl compounds, that are useful as disinfecting agents, and particularly useful in methods for the disinfection of biological fluids. Members of the class of compounds have been found to possess pathogen inactivating properties against a variety of pathogens. The compounds and methods disclosed herein are useful for disinfecting biological fluids such as blood and blood fractions, among others.

Abstract: A relay station utilizes the frequency hopping principle for the purpose of protection against intentional interference. Normally, the frequency hopping range available cannot be utilized for the frequency hopping operation because an indispensable minimum signal-to-noise ratio must be observed between the receiving frequency and the transmitting frequency of the relay station. In order to eliminate this disadvantage, the transmitter of the relay station is synchronized to the receiver by way of an interface connection and, with the aid of this synchronization, the desired frequency hopping in the entire available frequency hopping range for the transmitter and the receiver of the relay station can be controlled pursuant to observation of the required minimum signal-to-noise ratio.

Abstract: In radio operation in tactical use, an increased jamming resistance with respect to intentional jamming is required. For protection against intentional jamming, frequency hopping techniques have proven very advantageous in which the signals are transmitted in the form of successive error-protected signal blocks where each signal block is transmitted on a different radio carrier frequency which changes in a pseudo-random manner. With this technique, phase shifts can occur which are greater than half a bit and therefore make analysis of the signal blocks difficult or impossible. It is proposed herein that each received signal block be checked after regeneration in a regenerative repeater, controlled by a bit clock pulse, as to its correct block phase and therefore, respectively, newly establish the block clock pulse phase required for further accurate processing of a signal block.

Abstract: A method for the production of acetylene from coal and hydrogen is provided by electric arc heating. The coal has a content of volatile components (i.waf) from about 25 to 44 percent and a content of organic oxygen (i.waf) of less than 9 percent and is ground to a diameter of less than 0.5 mm. The coal is then separated into two to four grain size fractions and one of the grain size fractions is loaded on a hydrogen containing gas. The gas carrying the coal is heated by way of an electric arc with an energy of from about 5 to 20 kJ/l (in normal state). The ratio of electric power employed to coal stream is from about 4,000 to 40,000 kJ/kg coal. The coal is heated for a time duration about inversely proportional to the third root of the specific outer surface of the coal gain fraction. The resulting product gas is quenched with cold liquid hydrocarbons, with hydrogen or water. Acetylene yields of up to about 0.41 kg acetylene per kg coal can be obtained.

Abstract: A radiant burner comprises a burner housing containing a plurality of heat transfer elements which are heated by the hot combustion product gases produced by the burner. The burner housing is arranged to direct the combustible air-gas mixture into contact with the heat transfer elements to preheat the combustible air-gas mixture before passing through the burner plate to be burned. Means are provided for directing the hot combustion product gases into contact with the heat transfer elements whereby the heat is transmitted from the combustion air-gas mixture through the heat transfer elements to preheat the combustible air-gas mixture in the burner housing.