Patents by Inventor Herbert Berger
Herbert Berger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8388312Abstract: A compressor for an exhaust gas turbocharger includes an exhaust gas turbocharger housing having a gas intake port, which substantially radially encloses a gas inflow area. Disposed in the exhaust gas turbocharger housing is a compressor wheel, which can be driven by an exhaust gas turbine. The compressor wheel bounds the gas inflow area in the gas intake port in the direction of flow of a gas. The gas intake port includes indentations on a side of the inflow area. The flow noise in normal operation of the compressor and the acoustic effect in the case of pumping are reduced with the indentations.Type: GrantFiled: October 26, 2009Date of Patent: March 5, 2013Assignee: Bayerische Motoren Werke AktiengesellschaftInventors: Bernd Hollnbuchner, Herbert Berger, Daniel Fischer
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Publication number: 20100111676Abstract: A compressor for an exhaust gas turbocharger includes an exhaust gas turbocharger housing having a gas intake port, which substantially radially encloses a gas inflow area. Disposed in the exhaust gas turbocharger housing is a compressor wheel, which can be driven by an exhaust gas turbine. The compressor wheel bounds the gas inflow area in the gas intake port in the direction of flow of a gas. The gas intake port includes indentations on a side of the inflow area. The flow noise in normal operation of the compressor and the acoustic effect in the case of pumping are reduced with the indentations.Type: ApplicationFiled: October 26, 2009Publication date: May 6, 2010Applicant: Bayerische Motoren Werke AktiengesellschaftInventors: Bernd HOLLNBUCHNER, Herbert BERGER, Daniel FISCHER
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Publication number: 20070158474Abstract: In a dispensing adapter (1) for cartridges, cans or tubes adapted for storing and metered dispensing of highly viscous materials, in particular liquids such as adhesives, sealants, foamed-in plastics or the like, through a nozzle head, the nozzle head of the metering nozzle (6, 17) has several spaced-apart openings (7, 25) for discharge of the material.Type: ApplicationFiled: November 27, 2006Publication date: July 12, 2007Inventor: Herbert Berger
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Patent number: 4874756Abstract: The present invention provides compounds of the general formula ##STR1## wherein the variables are as defined herein. The present invention also provides processes for the preparation thereof, pharmaceutical compositions containing them and intermediates for the preparation thereof.Type: GrantFiled: August 29, 1986Date of Patent: October 17, 1989Assignee: Boehringer Mannheim GmbHInventors: Alfred Mertens, Wolfgang von der Saal, Herbert Berger, Bernd Muller-Beckmann, Klaus Strein
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Patent number: 4835280Abstract: The present invention provides Indolines of the formula: ##STR1## ps useful to provide pharmaceutically active pyrrolobenzimidazoles or tautomers thereof, of the formula: These compounds are useful for treating heart or circulatory diseases, especially those which respond to a change of blood pressure, an increase in cardiac output and/or a change in micro-circulation.Type: GrantFiled: July 14, 1987Date of Patent: May 30, 1989Assignee: Boehringer Mannheim GmbHInventors: Alfred Martens, Jens-Peter Holck, Herbert Berger, Bernd Muller-Beckman, Klaus Strein, Egon Roesch
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Patent number: 4831032Abstract: The present invention provides benzimidazoles of the general formula: ##STR1## wherein R.sub.1, X, A, and R.sub.2 are as defined in the specification. The present invention also provides processes for the preparation of these new benzimidazoles and pharmaceutical compositions containing them, as well as intermediates for the preparation thereof.The new benzimidazoles are useful to treat heart or circulatory diseases which respond to a lowering of blood pressure, a positive inotropic action and/or an improvement in microcirculation.Type: GrantFiled: July 3, 1986Date of Patent: May 16, 1989Assignee: Boehringer Mannheim GmbHInventors: Wolfgang von der Saal, Alfred Mertens, Herbert Berger, Bernd Muller-Beckmann, Klaus Strein
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Patent number: 4730003Abstract: The present invention provides compounds of the general formula: ##STR1## wherein the various substituents are defined hereinbelow. The compounds are used for the treatment and/or prophylaxis of heart and circulatory diseases.Type: GrantFiled: September 4, 1986Date of Patent: March 8, 1988Assignee: Boehringer Mannheim GmbHInventors: Wolfgang von der Saal, Alfred Mertens, Herbert Berger, Bernd Muller-Beckmann
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Patent number: 4695567Abstract: The present invention provided pyrrolobenzimidazoles or tautomer thereof, of the general formula: ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl or C.sub.3 -C.sub.7 cycloalkyl;R.sub.2 is hydrogen, cyano, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, or a carbonyl group substituted by hydroxyl, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkyoxy, amino, C.sub.1 -C.sub.6 alkylamino, C.sub.2 -C.sub.12 dialkylamino or hydrazino, orR.sub.2 and R.sub.1 together with the carbon to which they are attached form a C.sub.3 -C.sub.8 spirocycloalkyl ring, or R.sub.1 and R.sub.2 together form C.sub.3 -C.sub.7 alkylidene or C.sub.3 -C.sub.7 cycloalkylkidene,X is a valency bond, C.sub.1 -C.sub.Type: GrantFiled: January 17, 1986Date of Patent: September 22, 1987Assignee: Boehringer Mannheim GmbHInventors: Alfred Mertens, Jens-Peter Holck, Herbert Berger, Bernd Muller-Beckmann, Klaus Strein, Egon Roesch
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Patent number: 4410532Abstract: A 2-cyanaziridine derivative of the formula ##STR1## wherein R' is a straight-chained or branched, saturated or mono- or polyunsaturated aliphatic hydrocarbon radical with up to 8 carbon atoms, which is substituted by an aromatic nitrogen-containing heterocyclic radical with 5 or 6 ring-members and 1, 2 or 3 nitrogen atoms optionally substituted by halogen, alkoxy with up to 8 carbon atoms, alkyl with up to 8 carbon atoms, hydroxyl, carbalkoxy with up to 9 carbon atoms, carbamoyl, dialkylamino the alkyl moieties of which having up to 8 carbon atoms, cycloalkylamino, the cycloalkyl moiety having 3-10 carbon atoms, acetylamino, nitro, cyano, acetyl, alkylthio with up to 8 carbon atoms, alkylsulphinyl with up to 8 carbon atoms, alkylsulphonyl with up to 8 carbon atoms, sulphamoyl, phenyl, trifluoromethyl, phenoxy, acetoxy or methylenedioxy;or a pharmacologically acceptable salt thereof, exhibits immune stimulating activity.Type: GrantFiled: December 28, 1981Date of Patent: October 18, 1983Assignee: Boehringer Mannheim GmbHInventors: Elmar Bosies, Herbert Berger, Wolfgang Kampe, Uwe Bicker, Alfred Grafe
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Patent number: 4409236Abstract: Aziridine-2-carboxylic acid derivatives of the formula ##STR1## wherein X is a carboxyl, nitrile, alkoxycarbonyl or carbamoyl group, andR and R.sup.1 are various organic radicals; or pharmacologically acceptable salts thereof, exhibit marked immunostimulant activity, especially in conjunction with added chemotherapeutic agents such as a penicillin, a cephalosporin, a nitrofuran or chloramphenicol. Those compounds are new where X is a cyano group or an alkoxycarbonyl radical and R.sub.1 is a hydrogen atom, but R' is not an unsubstituted alkyl radical or an alkyl radical substituted by hydroxyl, alkoxy, dialkylamino, phenyl, 4-chlorophenyl or 4-methoxyphenyl or a vinyl radical substituted by a phenyl or methyl radical, or a cycloalkyl radical, a phenyl, a 4-chlorophenyl, a 4-methoxyphenyl, an s-triazinyl or a pyridinyl radical; or where X is a carbamoyl group and R.sub.Type: GrantFiled: June 1, 1981Date of Patent: October 11, 1983Assignee: Boehringer Mannheim GmbHInventors: Elmar Bosies, Herbert Berger, Wolfgang Kampe, Uwe Bicker, Alfred Grafe
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Patent number: 4321194Abstract: Aziridine-2-carboxylic acid derivatives of the formula ##STR1## wherein X is a carboxyl, nitrile, alkoxycarbonyl or carbamoyl group, andR and R.sup.1 are various organic radicals, or pharmacologically acceptable salts thereof, exhibit marked immunostimulant activity, especially in conjunction with added chemotherapeutic agents such as a penicillin, a cephalosporin, a nitrofuran or chloramphenicol. Those compounds are new where X is a cyano group or an alkoxycarbonyl radical and R.sub.1 is a hydrogen atom, but R' is not an unsubstituted alkyl radical or an alkyl radical substituted by hydroxyl, alkoxy, dialkylamino, phenyl, 4-chlorophenyl or 4-methoxyphenyl or a vinyl radical substituted by a phenyl or methyl radical, or a cycloalkyl radical, a phenyl a 4-chlorophenyl, a 4-methoxyphenyl, an s-triazinyl or a pyridinyl radical; or where X is a carbamoyl group and R.sub.Type: GrantFiled: July 23, 1979Date of Patent: March 23, 1982Assignee: Boehringer Mannheim GmbHInventors: Elmar Bosies, Herbert Berger, Wolfgang Kampe, Uwe Bicker, Alfred Grafe
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Patent number: 4282212Abstract: 1-(N-Acyl-carbamoyl)-2-cyanoaziridines of the formula ##STR1## wherein X is oxygen or sulphur,Z is hydrogen or an organic radical, andY is a carbonyl, sulphonyl, sulphinyl, sulphenyl, phosphoryl or phosphonyl radical,and salts thereof, exhibit immune-stimulating and cancerostatic activities.Type: GrantFiled: September 30, 1977Date of Patent: August 4, 1981Assignee: Boehringer Mannheim GmbHInventors: Herbert Berger, Rudi Gall, Wolfgang Kampe, Uwe Bicker, Gottfried Hebold
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Patent number: 4267174Abstract: 1-Acyl-2-cyanoaziridines of the formula ##STR1## wherein R is an acyl radical of a carboxylic, sulphonic, sulphinic, sulphenic, phosphonic or phosphoric acid,exhibit immune-stimulating and cancerostatic activities.Type: GrantFiled: June 16, 1978Date of Patent: May 12, 1981Assignee: Boehringer Mannheim, GmbHInventors: Herbert Berger, Rudi Gall, Wolfgang Kampe, Uwe Bicker, Rolf Kuhn
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Patent number: 4172136Abstract: New 3-nitropyrazole compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is cyano, carboxyl or lower alkoxycarbonyl or the radical --CO-NR.sub.4 R.sub.5, in whichR.sub.4 is hydrogen or hydroxyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, thiocarbamoyl, ureido, thioureido, hydroxyphenyl, picolyl or is a lower alkyl, alkenyl or cycloalkyl radical substituted, if desired, by a cyano, hydroxyl, pyrrolidino, piperidino, amino, lower alkylamino, lower dialkylamino or lower acylamino substituent andR.sub.5 is a hydrogen atom or a lower alkyl radical orR.sub.4 and R.sub.5 together represent a lower alkylene bridge;And the pharmacologically compatible salts thereof are outstandingly effective as anti-microbial agents, particularly systemically and in the urinary tract.Type: GrantFiled: March 23, 1978Date of Patent: October 23, 1979Assignee: Boehringer Mannheim GmbHInventors: Herbert Berger, Rudi Gall, Kurt Stach, deceased, Max Thiel, Wolfgang Vomel
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Patent number: 4105772Abstract: New 3-nitropyrazole compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is cyano, carboxyl or lower alkoxycarbonyl or the radical --CO--NR.sub.4 R.sub.5, in whichR.sub.4 is hydrogen or hydroxyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, thiocarbamoyl, ureido, thioureido, hydroxyphenyl, picolyl or is a lower alkyl, alkenyl or cycloalkyl radical substituted, if desired, by a cyano, hydroxyl, pyrrolidino, piperidino, amino, lower alkylamino, lower dialkylamino or lower acylamino substituent andR.sub.5 is a hydrogen atom or a lower alkyl radical orR.sub.4 and R.sub.5 together represent a lower alkylene bridge;And the pharmacologically compatible salts thereof, are outstandingly effective as anti-microbial agents, particularly systemically and in the urinary tract.Type: GrantFiled: November 22, 1976Date of Patent: August 8, 1978Assignee: Boehringer Mannheim GmbHInventors: Herbert Berger, Rudi Gall, Kurt Stach, deceased, by Werner Plattner, administrator, Max Thiel, Wolfgang Vomel
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Patent number: 4069330Abstract: New nitropyrazole compounds of the formula ##STR1## wherein R.sub.1 is alkyl or hydroxyalkylR.sub.2 and R.sub.3, which may be the same or different, are alkyl orR.sub.2 and R.sub.3 together represent a 4- or 5-membered alkylene bridge which is optionally interrupted by an oxygen atom or by the grouping >N-R, in which R is an alkyl or hydroxyalkyl radical;And the pharmacologically compatible salts thereof, possess excellent anti-microbial action not only in vitro but also in vivo, especially systemically.Type: GrantFiled: April 20, 1976Date of Patent: January 17, 1978Assignee: Boehringer Mannheim GmbHInventors: Herbert Berger, Rudi Gall, Max Thiel, Wolfgang Schaumann, Wolfgang Vomel
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Patent number: 4049811Abstract: Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##STR1## wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an alkylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.Type: GrantFiled: April 12, 1976Date of Patent: September 20, 1977Assignee: Boehringer Mannheim G.m.b.H.Inventors: Herbert Berger, Alfred Rhomberg, Kurt Stach, Wolfgang Vomel, Winfriede Sauer
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Patent number: 4034096Abstract: New cyclopenteno-quinolone derivatives of the formula ##STR1## wherein R is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.Type: GrantFiled: July 14, 1975Date of Patent: July 5, 1977Assignee: Boehringer Mannheim G.m.b.H.Inventors: Alfred Rhomberg, Herbert Berger, Kurt Stach, deceased, by Werner Plattner, administrator, Wolfgang Vomel, Winfriede Sauer
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Patent number: 4033967Abstract: New cyclopenteno-quinolone derivatives of the formula ##STR1## wherein R is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.Type: GrantFiled: October 17, 1974Date of Patent: July 5, 1977Assignee: Boehringer Mannheim G.m.b.H.Inventors: Alfred Rhomberg, Herbert Berger, Kurt Stach, deceased, Werner Plattner, administrator, Wolfgang Vomel, Winfriede Sauer
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Patent number: 4006141Abstract: Nitroimidazolyl-s-triazolo[4,3-b]pyridazines of the formula: ##STR1## wherein R is hydrogen or lower alkyl optionally substituted in the 2-position by hydroxyl or by lower acyloxy or lower alkoxy;A is hydrogen, halogen, azido, cyano; lower alkyl alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; orA is a radical of the formula: ##STR2## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or a number of organic radicals or, taken together, can be an alkylene bridge; andR.sub.3 is hydrogen or lower alkyl; or, together with R.sub.2, R.sub.3 can form an alkylene bridge;n is 0 or 1;And the pharmaceutically compatible thereof, possess high in vivo effectiveness as antimicrobials.Type: GrantFiled: July 31, 1975Date of Patent: February 1, 1977Assignee: Boehringer Mannheim G.m.b.H.Inventors: Herbert Berger, Rudi Gall, Kurt Stach, Wolfgang Vomel, Rita Hoffmann